Patents by Inventor J. Simons
J. Simons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140257437Abstract: Devices, systems and methods are disclosed for treating a variety of diseases and disorders that are primarily or at least partially driven by an imbalance in neurotransmitters in the brain, such as asthma, COPD, depression, anxiety, epilepsy, fibromyalgia, and the like. The invention involves the use of an energy source comprising magnetic and/or electrical energy that is transmitted non-invasively to, or in close proximity to, a selected nerve to temporarily stimulate, block and/or modulate the signals in the selected nerve such that neural pathways are activated to release inhibitory neurotransmitters in the patient's brain.Type: ApplicationFiled: May 23, 2014Publication date: September 11, 2014Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Publication number: 20140255949Abstract: An assay kit for determination of thymidine kinase (TK) activity in a biological sample, such as blood, serum, plasma, Cerebral Spinal Fluid (CSF), pleural fluid, ascites, tissues, cells and extracts thereof, is described. The assay kit can used in a method that comprises contacting, in a buffer, a Basic Reaction Mixture comprising: solid surface-attached primer and/or template, a modified deoxy nucleoside, such as BromodeoxyUridine, IododeoxyUridine, FluorodeoxyUridine or VinyldexoyThymidine as a kinase enzyme substrate, a phosphate donor, a nucleotide polymerizing enzyme, and a kinase enzyme source devoid of TK activity, such as a yeast extract, with the biological sample. After incubation the amount of modified deoxy nucleoside that has been incorporated into the solid surface-attached primer and/or template, is determined and the TK activity present in the biological sample is directly proportional to the amount of incorporated modified deoxy nucleoside.Type: ApplicationFiled: May 23, 2014Publication date: September 11, 2014Applicant: BIOVICA INTERNATIONAL ABInventor: J. Simon GRONOWITZ
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Publication number: 20140236272Abstract: A non-invasive electrical stimulator shapes an elongated electric field of effect that can be oriented parallel to a long nerve, such as a vagus nerve in a patient's neck, producing a desired physiological response in the patient. The stimulator comprises a source of electrical power, at least one electrode and a continuous electrically conducting medium in contact with the electrodes. The conducting medium is also in contact with an interface element that may conform to the contour of a target body surface of the patient when the interface element is applied to that surface. When the interface element is made of insulating (dielectric) material, and disclosed stimulation waveforms are used, the power source need not supply high voltage, in order to capacitively stimulate the target nerve.Type: ApplicationFiled: February 24, 2014Publication date: August 21, 2014Applicant: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Publication number: 20140213842Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: ApplicationFiled: March 29, 2014Publication date: July 31, 2014Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Publication number: 20140209713Abstract: A debris grinder interfaces directly with a typical roll-off container and a typical roll-off truck. By interfacing to the roll-off container, there is no need to feed waste by hand—an operation that is often dangerous to those operating the equipment. By interfacing with a typical roll-off truck, the debris grinder becomes mobile for spreading of the ground debris into the soil around the construction site. The debris grinder includes a skid portion for supporting and holding the roll-off container, a grinder portion for grinding debris from the roll-off container and depositing the ground-up debris onto the soil at the job site.Type: ApplicationFiled: January 28, 2013Publication date: July 31, 2014Applicant: GATEWAY NATIONAL STORAGE, LLCInventors: Paul J. Simon, Matthew C. Ruthig
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Publication number: 20140214120Abstract: Devices, systems and methods are disclosed for modulating cranial nerves, such as the sphenopalatine ganglion, to treat a medical condition of a patient, such as cluster headache. A stimulation device is advanced transnasally to a target site at or adjacent to the nasopharyngeal mucosa posterior to the middle turbinate. Electrical impulses are applied through one or more electrodes in the stimulation device to the target nerve sufficient to modulate the nerve and treat the medical condition.Type: ApplicationFiled: January 27, 2014Publication date: July 31, 2014Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico
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Publication number: 20140207224Abstract: The present invention provides systems, apparatus and methods for applying electric current to neurons in the brain to treat disorders and to improve motor and/or memory functions in a patient. In a method according to the invention, an electrode is positioned adjacent to and spaced from the skin surface of the patient's head and an electric current is applied through the electrode to a target region in the brain to modulate one or more neurons in the target region. The electrode is housed within an enclosure and spaced from the skin surface so that the electrode does not directly contact the patient's tissue, which reduces the potential for collateral tissue damage or necrosis and shields the electrode from the patient's tissue which substantially inhibits Faradic products (e.g., H+, OH?, H2O2) of the electrode from reaching the target site.Type: ApplicationFiled: March 24, 2014Publication date: July 24, 2014Applicant: ElectroCore, LLCInventor: Bruce J. Simon
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Patent number: 8779627Abstract: A grid tie system includes a plurality of solar panels, a plurality of inverters, wherein each of the inverters is in electrical communication with at least one of the solar panels to convert a direct current to an alternating current, wherein each of the inverters has an active state and an inactive state and at least one of the inverters includes a tracking component to track a maximum power point of at least one of the solar panels, and a controller in communication with at least one of the inverters for selectively toggling the at least one of the inverters between the active state and the inactive state.Type: GrantFiled: April 1, 2010Date of Patent: July 15, 2014Assignee: Nextronex, Inc.Inventors: Peter F. Gerhardinger, David R. Feltner, Richard L. Ashton, Robert J. Simons
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Patent number: 8765378Abstract: A method and assay kit for determination of thymidine kinase (TK) activity in a biological sample, such as blood, serum, plasma, Cerebral Spinal Fluid (CSF), pleural fluid, ascites, tissues, cells and extracts thereof, is described. The method comprises contacting, in a buffer, a Basic Reaction Mixture comprising: solid surface-attached primer and/or template, a modified deoxy nucleoside, such as BromodeoxyUridine, IododeoxyUridine, Fluorodeoxy-Uridine or VinyldexoyThymidine as a kinase enzyme substrate, a phosphate donor, a nucleotide polymerizing enzyme, and a kinase enzyme source devoid of TK activity, such as a yeast extract, with the biological sample. After incubation the amount of modified deoxy nucleoside that has been incorporated into the solid surface-attached primer and/or template, is determined and the TK activity present in the biological sample is directly proportional to the amount of incorporated modified deoxy nucleoside.Type: GrantFiled: February 24, 2006Date of Patent: July 1, 2014Assignee: Biovica International ABInventor: J. Simon Gronowitz
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Patent number: 8750468Abstract: In one or more embodiments, one or more methods and/or systems described can transform an inbound call into one or more call streams and/or call states that can include at least one of a contextualized or personalized message, a promotion, a coupon, an offer, a voucher, an advertisement, and an opt-in program, among others. For example, the one or more methods and/or systems described can perform: receiving identification information associated with a telephony device; determining, based on the identification information, a message for the user; and sending the message to the telephony device. For instance, the message can include a coupon or discount for a good or service. In one example, the coupon or discount can be sent via a short message service text message. In another example, the coupon or discount can include a computer-readable image that can be sent via a multimedia messaging service message.Type: GrantFiled: October 5, 2010Date of Patent: June 10, 2014Assignee: CallSpace, Inc.Inventors: Richard J. Manley, Craig Fryar, Michael Lee, Carmichael J. Simon, William C. Archibald
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Publication number: 20140150014Abstract: A new television broadcast model called a Broadcast Market Exchange (BMX) eliminates the inefficiency in spectrum usage, providing maximum flexibility in delivering content through either VHF (for fixed location receiving devices) or UHF (optimized for mobile receiving devices) transmission/propagation. In conjunction with the BMX, a wireless communications system architecture is provided to enable a broadcast augmentation channel. The augmentation channel provides supplementation of the Quality of Service (QoS) of a one way User Datagram Protocol (UDP) delivery environment. The augmentation channel may be comprised of one or more physical delivery mechanisms (wired or wireless), but can be effectively unified for increasing QoS and or scalable levels of service (additional essence) to improve the user experience.Type: ApplicationFiled: November 28, 2013Publication date: May 29, 2014Applicant: Sinclair Broadcast Group, Inc.Inventors: Mark A. Aitken, Michael J. Simon
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Publication number: 20140142654Abstract: Devices, systems and methods are disclosed that allow a patient to self-treat a medical condition, such as migraine headache, by electrical noninvasive stimulation of a vagus nerve. The system comprises a stimulator that is applied to the surface of the patient's neck, as well as a docking station that is used to charge a rechargeable battery within the stimulator. The docking station and stimulator housing transmit data to one another regarding the status of a stimulation session, as well as to a computer program in a patient interface device such as a mobile phone or computer. The interface device in turn communicates with medical record and billing databases contained within other computers, via the internet. The system is designed to address problems that arise particularly during self-treatment, when a medical professional is not present.Type: ApplicationFiled: April 8, 2013Publication date: May 22, 2014Applicant: ElectroCore, LLC.Inventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Patent number: 8732818Abstract: End-to-end authentication capability based on public-key certificates is combined with the Session Initiation Protocol (SIP) to allow a SIP node that receives a SIP request message to authenticate the sender of request. The SIP request message is sent with a digital signature generated with a private key of the sender and may include a certificate of the sender. The SIP request message my also be encrypted with a public key of the recipient. After receiving the SIP request, the receiving SIP node obtains a certificate of the sender and authenticates the sender based on the digital signature. The digital signature may be included in an Authorization header of the SIP request, or in a multipart message body constructed according to the S/MIME standard.Type: GrantFiled: September 28, 2012Date of Patent: May 20, 2014Assignee: Microsoft CorporationInventors: Jeremy T. Buch, David J. Simons
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Publication number: 20140132128Abstract: A refrigerator with rotating and segmented shelving has a cabinet with at least one round internal compartment, a shaft centered within the compartment, and segments connecting to the shaft. The invention may also provide a motor connected to the shaft for rotating it and the shelving. Preferably, the shaft has a square cross section that receives up to four segments in a common plane. The shaft uses connections that receive the segments. Alternatively, the shaft has a round cross section for up to six segments upon a common plane. Each segment has a narrow nose that fits into the connection upon the shaft and an opposite wide edge outwardly towards the cabinet. Alternatively the cabinet or a door is at least partially transparent. A user may arrange shelf segments at different planes, thus accommodating foods and beverages of varying heights.Type: ApplicationFiled: November 9, 2012Publication date: May 15, 2014Inventor: Gary J. Simon
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Patent number: 8713092Abstract: Disclosed is a system for servers to redirect client requests to other servers in order to distribute client traffic among the servers. A client is assigned to a server although the client may be unaware of that assignment. When the client accesses a server, a server possibly identified to the client by a name service, the server checks the client's assignment. If the client is not assigned to this server, then in some scenarios this server redirects the client to its assigned server. The client responds by sending its request to the assigned server. In other scenarios, the first server accessed by the client proxies the client's traffic to the assigned server. A database is kept of client-to-server assignments. If the present load distribution is less than ideal (e.g., clients are assigned to an unavailable server), then the assignment database is updated to reflect how the load should be distributed.Type: GrantFiled: February 10, 2009Date of Patent: April 29, 2014Assignee: Microsoft CorporationInventors: Vishwajith Kumbalimutt, David J. Simons, Robert I. Brown, Elena Apreutesei
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Publication number: 20140107398Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: ApplicationFiled: September 16, 2013Publication date: April 17, 2014Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Publication number: 20140107397Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.Type: ApplicationFiled: September 16, 2013Publication date: April 17, 2014Applicant: ElectroCore, LLCInventors: Bruce J. Simon, Joseph P. Errico, John T. Raffle
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Publication number: 20140107745Abstract: The present invention includes methods and devices for treating hypotension, such as in cases of shock, including septic shock, anaphylactic shock and hypovolemia. The method includes the step of applying at least one electrical impulse to at least one selected region of a parasympathetic nervous system of the patient. The electrical impulse is sufficient to modulate one or more nerves of the parasympathetic nervous system to increase the ratio of blood pressure to heart rate and relieve the condition and/or extend the patient's life.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: Electrocore, LLCInventors: Bruce J. Simon, Joseph P. Errico, Steven Mendez
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Patent number: 8691724Abstract: An inlet face for an aftertreatment device that prevents and/or eliminates face-plugging for a passageway where the inlet face is disposed. The inlet face includes a particular end surface disposed on an outer surface at the end of a substrate. The end surface includes at least one of a three-dimensional topographical configuration disposed at the end of the substrate, a chemical coating applied on the end of the substrate, or both a three-dimensional topographical configuration disposed on the end of the substrate and a chemical coating applied on the three-dimensional topographical configuration. As one example, the inlet face can be helpful in preventing carbonaceous fouling, which can result from engine exhaust material, such as carbon soot and other engine exhaust by-products.Type: GrantFiled: September 4, 2012Date of Patent: April 8, 2014Assignee: Cummins Filtration IP, Inc.Inventors: Conrad J. Simon, III, Thomas M. Yonushonis, Bryan E. Blackwell
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Patent number: 8682449Abstract: Systems, apparatus and methods are described for applying electric current to neurons in the brain to treat disorders and to improve motor and/or memory functions in a patient. In a method according to the invention, an electrode is positioned adjacent to and spaced from the skin surface of the patient's head and an electric current is applied through the electrode to a target region in the brain to modulate one or more neurons in the target region. The electrode is housed within an enclosure and spaced from the skin surface so that the electrode does not directly contact the patient's tissue, which reduces the potential for collateral tissue damage or necrosis and shields the electrode from the patient's tissue which substantially inhibits Faradic products (e.g., H+, OH?, H2O2) of the electrode from reaching the target site.Type: GrantFiled: August 27, 2009Date of Patent: March 25, 2014Assignee: Electrocore, LLCInventor: Bruce J. Simon