Abstract: A laser rod surface elevation table (L-RSET) includes a sensor arm coupled to a stepper motor and a screw frame. A screw interconnects the motor and frame, while a screw carriage interconnects the screw and a sensor carriage. A laser sensor is mounted to the sensor carriage. A controller includes at least one processor operatively coupled to the sensor and motor. The processor processes measurement values in a data structure and performs functions to actuate the motor and sensor. The data structure represents a quasi-unique topographical measurement project, and is configured with the measurement values, including a radius value R which defines an area, a start point value X and a stop point value Y for positioning the screw carriage, a speed value S for speed of advancement of the screw carriage, an interval value I for measurement interval, and a points value N for points of measurement per measurement interval.

Abstract: A network component placement architecture addresses the difficult technical challenge of determining where specific technical components of an overall service may be provisioned. The architecture is particularly effective at determining where, among a myriad of possible service provides, platforms, and regions, the technical components can be placed and meet all of the applicable technical constraints on the placement of the technical components. In one implementation, the placement architecture includes a sequence of pipeline stages that define an analysis sequence leading to a set of possible placement options.

Abstract: Determining placement options for technical components of a specified service is a difficult technical challenge. A metadata architecture addresses, in part, the technical challenge by defining a complex metadata collection and attachment mechanism. In one implementation, the metadata architecture defines metadata domains and obtains descriptive metadata for those domains, e.g., metadata for the technical components from multiple disparate sources and across multiple different characteristics of the technical components. The metadata architecture is linked to the technical components and the metadata architecture injects specific metadata subsets into, e.g., a placement pipeline that determines where the technical components may be placed in the extensive provider/platform/service space.

Abstract: A network component placement architecture addresses the difficult technical challenge of determining where specific technical components of an overall service may be provisioned. The architecture is particularly effective at determining where, among a myriad of possible service provides, platforms, and regions, the technical components can be placed and meet all of the applicable technical constraints on the placement of the technical components. In one implementation, the placement architecture includes a sequence of pipeline stages that define an analysis sequence leading to a set of possible placement options.

Abstract: A network component placement architecture addresses the difficult technical challenge of determining where specific technical components of an overall service may be provisioned. However, the placement decision can change over time in response to complex updates relating to service providers, the regions they support, the assets they support, and many other dynamic factors. Dynamic network component placement effectively determines updated possibilities for placing the technical components of a specified service, while meeting all of the applicable technical constraints on the placement of the technical components.

Abstract: Provisioning resources into the cloud is a constantly increasing technical challenge as more cloud service providers emerge, each offering disparate computing platforms, services, assets, supported technical components, and other features. A cloud computing provisioning architecture implements a sequence of complex technical analyses that successfully provisions complex cloud computing services. The provisioning architecture disaggregates resources into individual provisioning actions, and also selectively re-aggregates the resources into template blocks which a service provider accepts for native provisioning.

Abstract: Cloud computing has emerged as an extremely popular implementation option for a wide range of computing services. However, provisioning services into the cloud is an extremely difficult technical challenge. This is due in part to the regular emergence of new cloud service providers, as well as the routine changing and reconfiguration of the disparate computing platforms, services, assets, supported technical components, and other features offered by the service providers. An analysis architecture determines how to map a particular technical component into the execution environment of any particular service provider.

Abstract: Provisioning resources into the cloud is a constantly increasing technical challenge as more cloud service providers emerge, each offering disparate computing platforms, services, assets, supported technical components, and other features. A cloud computing provisioning architecture implements a sequence of complex technical analyses that successfully provisions complex cloud computing services.

Abstract: A window screen system including two main parts, namely, a reinforced window frame and a combined window and a force resistant flex screen system or assembly. The window frame has at least one forward and one reward vertical slot capable of receiving the combined window and flex screen. The frame is securable to a structure and extends thereinto providing for easy removal of the systems received in the vertical slots. The screen system is formed of a mesh flex screen material. Winding rods, with teeth extending therefrom, line each edge of the flex screen and engage the screen material rotatably secure the screen with the teeth. Each juncture of the winding rods is secured by a corner cap. The flex screen system is sealed with a polymer seal about the winding rods. A screen cap is securely placed along the top edge and secured by the polymer seal.

Abstract: A system for ablating internal heart tissue in an ablation pattern on a surface of the tissue within the heart. The system includes an ablation catheter with a distal end having an ablating tip portion operative to allow selective ablation of tissue. A guiding device is engageable with the ablation catheter and includes a tissue anchoring portion operable to engage with tissue proximate to the tissue to be ablated so as to temporarily anchor the guiding device relative to the tissue. Engagement of the guiding device with the ablation catheter operates to assist with guiding the ablating tip portion in moving along the pattern. Various devices and methods of use are further disclosed.

Abstract: A system (60) for ablating internal heart tissue (12) in an ablation pattern (50) on a surface of the tissue within the heart. The system (60) includes an ablation catheter (14) with a distal end having an ablating tip portion (20) operative to allow selective ablation of tissue. A guiding device (62) is engageable with the ablation catheter (14) and includes a tissue anchoring portion (74) operable to engage with tissue proximate to the tissue to be ablated so as to temporarily anchor the guiding device (62) relative to the tissue (12). Engagement of the guiding device (62) with the ablation catheter (14) operates to assist with guiding the ablating tip portion (20) in moving along the pattern (50). Various devices and methods of use are further disclosed.

Abstract: A method for characterizing a musical recording as a set of scalar descriptors, each of which is based on human perception. A group of people listens to a large number of musical recordings and assigns to each one many scalar values, each value describing a characteristic of the music as judged by the human listeners. Typical scalar values include energy level, happiness, danceability, melodicness, tempo, and anger. Each of the pieces of music judged by the listeners is then computationally processed to extract a large number of parameters which characterize the electronic signal within the recording. Algorithms are empirically generated which correlate the extracted parameters with the judgments based on human perception to build a model for each of the scalars of human perception. These models can then be applied to other music which has not been judged by the group of listeners to give to each piece of music a set of scalar values based on human perception.

Abstract: The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.

Abstract: An endoscopic closure device comprises: a coupling member; a helical needle mounted to the coupling member and carrying a suture; and a plurality of grasping needles, each of said plurality of grasping needles moveable between a storage position and a deployed position. The plurality of grasping needles is configured to be (a) advanced in the storage position into a luminal defect, (b) moved into the deployed position, and (c) then refracted from the luminal defect, thus pulling and drawing tissue surrounding the luminal defect together. Then, upon rotation of the coupling member and the helical needle, the helical needle is driven into and pierces the tissue, carrying the suture through the tissue.

Abstract: A bee transportation system is configured to ship a bee box and has a bee container having a front side and a rear side and further configured to accommodate the bee box and the feeder can. At least one front ventilation port is arranged on the front side and configured to permit air to pass through the bee container and the bee box. At least one rear ventilation port is arranged on the front side and configured to permit the air to pass through the bee container and the bee box. Flaps are mechanically coupled to the bee container and configured to hold the feeder can in place. The bee container creates an insulated environment for the bee box. The ventilation ports are configured to prevent bee stingers from extending through the ventilation ports which prevents injuries.

Abstract: A method for characterizing a musical recording as a set of scalar descriptors, each of which is based on human perception. A group of people listens to a large number of musical recordings and assigns to each one many scalar values, each value describing a characteristic of the music as judged by the human listeners. Typical scalar values include energy level, happiness, danceability, melodicness, tempo, and anger. Each of the pieces of music judged by the listeners is then computationally processed to extract a large number of parameters which characterize the electronic signal within the recording. Algorithms are empirically generated which correlate the extracted parameters with the judgments based on human perception to build a model for each of the scalars of human perception. These models can then be applied to other music which has not been judged by the group of listeners to give to each piece of music a set of scalar values based on human perception.

Abstract: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

Abstract: The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

Abstract: A window screen system including two main parts, namely, a reinforced window frame and a combined window and a force resistant flex screen system or assembly. The window frame has at least one forward and one reward vertical slot capable of receiving the combined window and flex screen. The frame is securable to a structure and extends thereinto providing for easy removal of the systems received in the vertical slots. The screen system is formed of a mesh flex screen material. Winding rods, with teeth extending therefrom, line each edge of the flex screen and engage the screen material rotatably secure the screen with the teeth. Each juncture of the winding rods is secured by a corner cap. The flex screen system is sealed with a polymer seal about the winding rods. A screen cap is securely placed along the top edge and secured by the polymer seal.

Abstract: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.