Abstract: A method for characterizing a musical recording as a set of scalar descriptors, each of which is based on human perception. A group of people listens to a large number of musical recordings and assigns to each one many scalar values, each value describing a characteristic of the music as judged by the human listeners. Typical scalar values include energy level, happiness, danceability, melodicness, tempo, and anger. Each of the pieces of music judged by the listeners is then computationally processed to extract a large number of parameters which characterize the electronic signal within the recording. Algorithms are empirically generated which correlate the extracted parameters with the judgments based on human perception to build a model for each of the scalars of human perception. These models can then be applied to other music which has not been judged by the group of listeners to give to each piece of music a set of scalar values based on human perception.

Abstract: In a mass spectrometer, a dual stage axial extraction field is applied to transport ions from an accumulator to a detector cell. Ions of a same mass may be transported to the detector cell or a point axially preceding the detector cell at the same time. This may be done by selecting the relative strengths of a first axial electric field applied to the accumulator and a second axial electric field applied to a shutter located at an exit end of the accumulator. This may also be done by selecting relative axial lengths of the accumulator, shutter, and an ion guide located at an exit end of the shutter. A dual stage decelerating field may also be applied to slow ions down prior to and after entering the detector cell.

Abstract: A sample is ionized by chemical ionization by flowing the sample and a reagent gas into an ion source at a pressure below 0.1 Torr. While maintaining the ion source at a pressure below 0.1 Torr, the reagent gas is ionized in the ion source by electron ionization to produce reagent ions. The sample is reacted with the reagent ions at a pressure below 0.1 Torr to produce product ions of the sample. The product ions are transmitted into an ion trap for mass analysis.

Abstract: A system (60) for ablating internal heart tissue (12) in an ablation pattern (50) on a surface of the tissue within the heart. The system (60) includes an ablation catheter (14) with a distal end having an ablating tip portion (20) operative to allow selective ablation of tissue. A guiding device (62) is engageable with the ablation catheter (14) and includes a tissue anchoring portion (74) operable to engage with tissue proximate to the tissue to be ablated so as to temporarily anchor the guiding device (62) relative to the tissue (12). Engagement of the guiding device (62) with the ablation catheter (14) operates to assist with guiding the ablating tip portion (20) in moving along the pattern (50). Various devices and methods of use are further disclosed.

Abstract: The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

Abstract: A solid phase extraction apparatus includes a sample adsorption assembly and a needle. The adsorption assembly includes a housing, a distal housing opening, and an adsorption bar disposed in the housing. The adsorption bar includes an outer surface coated with an adsorption material. The adsorption bar is located between the distal housing opening and a proximal housing opening. The outer surface is spaced from an inner housing surface, wherein the adsorption assembly includes an adsorption region between the inner housing surface and the outer surface. The adsorption assembly establishes a fluid flow path from the distal housing opening, through the adsorption region along a longitudinal direction, and to the proximal housing opening.

Abstract: An electron capture dissociation apparatus comprises ion guide electrodes, an electron emitter, and an electron control device. The ion guide electrodes are arranged along a central axis and spaced circumferentially to circumscribe an interior space extending along the central axis. The electron emitter is disposed outside the interior space. The electron control device is configured for focusing an electron beam from the electron emitter toward the central axis, along a radial electron beam direction between two of the ion guide electrodes, and for decelerating the electron beam in a DC decelerating field of adjustable voltage potential directed along the electron beam direction.

Abstract: The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

Abstract: An endoscopic closure device comprises: a coupling member; a helical needle mounted to the coupling member and carrying a suture; and a plurality of grasping needles, each of said plurality of grasping needles moveable between a storage position and a deployed position. The plurality of grasping needles is configured to be (a) advanced in the storage position into a luminal defect, (b) moved into the deployed position, and (c) then refracted from the luminal defect, thus pulling and drawing tissue surrounding the luminal defect together. Then, upon rotation of the coupling member and the helical needle, the helical needle is driven into and pierces the tissue, carrying the suture through the tissue.

Abstract: The present invention provides a compound of formula I or a salt form thereof, wherein Q1, Q2, Q3, and Q4 are as defined herein. The compound of formula I has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.

Abstract: The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.

Abstract: The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.

Abstract: A method and device for protecting a surface. The device includes modular spaced armor assemblies having a ceramic face plate, a composite backing plate, and a lightweight low-density module therebetween. The modular spaced armor assemblies may be tiled to form a protective arrangement for protecting a desired surface. The lightweight low-density module includes one or more gas filled cavities.

Abstract: A sample is ionized by chemical ionization by flowing the sample and a reagent gas into an ion source at a pressure below 0.1 Torr. While maintaining the ion source at a pressure below 0.1 Torr, the reagent gas is ionized in the ion source by electron ionization to produce reagent ions. The sample is reacted with the reagent ions at a pressure below 0.1 Torr to produce product ions of the sample. The product ions are transmitted into an ion trap for mass analysis.

Abstract: A cargo transportation device includes a lift assembly for raising and lowering cargo and an operator cabin in which an operator controls the lift assembly. A load backrest is coupled to the cabin, and an automatic data collection device, which is configured to interrogate wireless communication devices, is coupled to the load backrest. The cargo transportation device includes a computing device having logic for controlling the automatic data collection device and logic for controlling the lift assembly, and a display device in communication with the computing device. The display device is coupled to the cabin and configured to provide the operator with information from the computing device.

Abstract: The present invention is directed to novel multicyclic molecules that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP, VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.

Abstract: In a mass spectrometer, a dual stage axial extraction field is applied to transport ions from an accumulator with a shutter and an ion guide to a detector cell. Ions of the same mass may be transported to the detector cell or a point axially preceding the detector cell at the same time by selecting the relative strengths of a first axial electric field applied to the accumulator and a second axial electric field applied to the shutter and further by selecting relative axial lengths of the accumulator, shutter, and an ion guide. A dual stage decelerating field may also be applied to slow ion down prior to and after entering the detector cell.

Abstract: An atmospheric pressure ionization apparatus with a plurality of sprayers configured for producing separate gas streams comprising charged material, an interface structure, and a capillary. The interface structure includes a plurality of entrance orifices aligned on-axis or off-axis with respective sprayers, a plurality of desolvating passages extending from the entrance orifices to respective passage outlets, and a common passage communicating with the passage outlets. The desolvating passages form a plurality of input flow paths running from the entrance orifices and merging into the common passage. The capillary communicates with the common passage and extends therefrom to a capillary outlet positioned outside the interface structure, wherein the capillary forms a single output flow path running from the merged input flow paths to the capillary outlet. Desolvated ions from the first and second passages may be flowed together through the capillary as a mixture, or may be flowed sequentially.

Abstract: An electron capture dissociation apparatus comprises ion guide electrodes, an electron emitter, and an electron control device. The ion guide electrodes are arranged along a central axis and spaced circumferentially to circumscribe an interior space extending along the central axis. The electron emitter is disposed outside the interior space. The electron control device is configured for focusing an electron beam from the electron emitter toward the central axis, along a radial electron beam direction between two of the ion guide electrodes, and for decelerating the electron beam in a DC decelerating field of adjustable voltage potential directed along the electron beam direction.

Abstract: The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.