Patents by Inventor József Toth
József Toth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240000911Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular gastric cancer, lung cancer, melanoma and bladder cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: May 2, 2023Publication date: January 4, 2024Inventors: Julianna Lisziewicz, Levente Molnár, Eniko Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20230405100Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: February 8, 2023Publication date: December 21, 2023Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Patent number: 11666644Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular gastric cancer, lung cancer, melanoma and bladder cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: September 3, 2019Date of Patent: June 6, 2023Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnar, Eniko Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pantya, Mónika Megyesi
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Publication number: 20230158137Abstract: The disclosure relates to polypeptides, vaccines and pharmaceutical compositions that find use in the prevention or treatment of Coronaviridae or SARS-CoV-2 infection. The disclosure also relates to methods of treating or preventing Coronaviridae or SARS-CoV-2 infection in a subject. The polypeptides and vaccines comprise B cell epitopes and cytotoxic and helper T cell epitopes that are immunogenic in a high percentage of subjects in the human population.Type: ApplicationFiled: April 1, 2021Publication date: May 25, 2023Inventors: Zsolt Csiszovszki, Orsolya Lörincz, Levente Molnár, Péter Páles, Katalin Pántya, Eszter Somogyi, József Tóth, Eniko Rita Toke
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Patent number: 11628211Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: December 22, 2021Date of Patent: April 18, 2023Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20230102031Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular gastric cancer, lung cancer, melanoma and bladder cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: September 3, 2019Publication date: March 30, 2023Inventors: Julianna LISZEWICZ, Levente MOLNAR, Eniko TOKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PANTYA, Mónika MEGYESI
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Patent number: 11426452Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: December 22, 2021Date of Patent: August 30, 2022Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220233660Abstract: The disclosure relates to a method for determining the risk that a human subject will develop a cancer, the method comprising quantifying the HLA triplets (HEAT) of the subject that are capable of binding to T cell epitopes in the amino acid sequence of tumor associated antigens. The disclosure also relates to methods of treating subjects who are determined to have an elevated risk of developing cancer.Type: ApplicationFiled: September 3, 2019Publication date: July 28, 2022Inventors: Julianna LISZEWICZ, Levente MOLNAR, Eniko TOKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PANTYA, Péter PÁLES, István MIKLÓS, Mónika MEGYESI
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Publication number: 20220160854Abstract: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple alleles of receptors of the highest proportion of subjects in a target population.Type: ApplicationFiled: February 8, 2022Publication date: May 26, 2022Inventors: Levente Molnár, Eniko R. Toke, Julianna Lisziewicz, József Tóth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi, Péter Páles
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Publication number: 20220111024Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: December 22, 2021Publication date: April 14, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220111025Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: December 22, 2021Publication date: April 14, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220072114Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing pharmaceutical compositions comprising such polypeptide fragments, pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of individual subjects.Type: ApplicationFiled: November 9, 2021Publication date: March 10, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20220031823Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing personalised pharmaceutical compositions comprising such polypeptide fragments, human subject-specific pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of the subject.Type: ApplicationFiled: September 17, 2021Publication date: February 3, 2022Inventors: Julianna Lisziewicz, Levente Molnár, Eniko R. Toke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Patent number: 11213578Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: GrantFiled: January 10, 2019Date of Patent: January 4, 2022Assignee: Treos Bio LimitedInventors: Julianna Lisziewicz, Levente Molnár, Enikő R. Tőke, József Toth, Orsolya Lorincz, Zsolt Csiszovszki, Eszter Somogyi, Katalin Pántya, Mónika Megyesi
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Publication number: 20210236611Abstract: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple alleles of receptors of the highest proportion of subjects in a target population.Type: ApplicationFiled: February 26, 2021Publication date: August 5, 2021Inventors: Levente MOLNÁR, Eniko R. TOKE, Julianna LISZIEWICZ, József TÓTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI, Péter PÁLES
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Patent number: 10973909Abstract: The disclosure relates to polypeptides, vaccines and pharmaceutical compositions that find use in the prevention or treatment of Coronaviridae or SARS-CoV-2 infection. The disclosure also relates to methods of treating or preventing Coronaviridae or SARS-CoV-2 infection in an individual. The polypeptides and vaccines comprise T cell and/or B cell epitopes that are immunogenic in a high percentage of individuals in the human population.Type: GrantFiled: April 7, 2020Date of Patent: April 13, 2021Assignee: PepTC Vaccines LimitedInventors: Zsolt Csiszovszki, Orsolya Lörincz, Levente Molnár, Péter Páles, Katalin Pántya, Eszter Somogyi, József Tóth, Enikö R. Töke
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Patent number: 10800244Abstract: The disclosure concerns a motor vehicle with an exhaust silencer arranged at a rear axle. At least one battery receptacle is arranged adjacent to and at least partially at a side and/or rear of the vehicle component on a rear floor, and formed as a tray. At least one battery is arranged at least partially in the battery receptacle. At least one deflector element is arranged between the battery receptacle and the vehicle component. And the deflector element is configured such that the vehicle component, standing in contact with the deflector element due to a sideways and/or forward displacement of the vehicle component, is pressed downward by the exhaust silencer in a floor direction.Type: GrantFiled: August 22, 2018Date of Patent: October 13, 2020Assignee: Ford Global Technologies, LLCInventors: Marius Sawatzki, Hauke Weber, Jozsef Toth, Daniel Meckenstock
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Publication number: 20200069786Abstract: The disclosure relates to polypeptides, polynucleic acids and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods. The disclosure also relates to a method of preparing a peptide or polynucleic acid for use in a method of inducing a T cell response against a target polypeptide, wherein the method comprises identifying epitopes in the antigen that bind to multiple HLA alleles of the highest proportion of subjects in a target population.Type: ApplicationFiled: September 3, 2019Publication date: March 5, 2020Inventors: Levente MOLNÁR, Enikõ R. TÕKE, Julianna LISZEWICZ, József TÓTH, Orsolya LÕRINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI, Péter PÁLES
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Publication number: 20190314711Abstract: A bowling ball stop assembly for a pinsetter of a bowling lane is provided. The bowling ball stop assembly can include a moveable blocking feature that moves between a plurality of positions. The plurality of positions include an extended position with the stop arranged in front of the pinsetter to block or obstruct bowling balls moving down the bowling lane, and a retracted position with the stop raised away from the bowling lane to allow passage of bowling balls and the play of bowling games thereon. The bowling ball stop assembly further includes a frame supporting the blocking feature and configured to guide or facilitate control of movement thereof between the extended and retracted positions. Other aspects also are described.Type: ApplicationFiled: April 10, 2019Publication date: October 17, 2019Inventors: Michael Resterhouse, József Tóth, Károly Bálint, Attila Lévai, István Hegymegi, Ákos Csorba
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Publication number: 20190240302Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.Type: ApplicationFiled: January 10, 2019Publication date: August 8, 2019Inventors: Julianna LISZIEWICZ, Levente MOLNÁR, Eniko R. TOKE, József TOTH, Orsolya LORINCZ, Zsolt CSISZOVSZKI, Eszter SOMOGYI, Katalin PÁNTYA, Mónika MEGYESI