Abstract: The disclosure concerns a motor vehicle with an exhaust silencer arranged at a rear axle. At least one battery receptacle is arranged adjacent to and at least partially at a side and/or rear of the vehicle component on a rear floor, and formed as a tray. At least one battery is arranged at least partially in the battery receptacle. At least one deflector element is arranged between the battery receptacle and the vehicle component. and the deflector element is configured such that the vehicle component, standing in contact with the deflector element due to a sideways and/or forward displacement of the vehicle component, is pressed downward by the exhaust silencer in a floor direction.

Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.

Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing pharmaceutical compositions comprising such polypeptide fragments, pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of individual subjects.

Abstract: The disclosure relates to methods of identifying fragments of a polypeptide that are immunogenic for a specific human subject, methods of preparing personalised pharmaceutical compositions comprising such polypeptide fragments, human subject-specific pharmaceutical compositions comprising such polypeptide fragments, and methods of treatment using such compositions. The methods comprise identifying a fragment of the polypeptide that binds to multiple HLA of the subject.

Abstract: The disclosure relates to polypeptides and pharmaceutical compositions comprising polypeptides that find use in the prevention or treatment of cancer, in particular breast cancer, ovarian cancer and colorectal cancer. The disclosure also relates to methods of inducing a cytotoxic T cell response in a subject or treating cancer by administering pharmaceutical compositions comprising the peptides, and companion diagnostic methods of identifying subjects for treatment. The peptides comprise T cell epitopes that are immunogenic in a high percentage of patients.

Abstract: The firearm with pressure accumulator (5) having increased battering charge (3) and barrel (1) length has a piston (43) sliding in the accumulator housing (41) fixed to the breech (6) and springs (38, 38, 40) supporting the piston. To create a pneumatic spring (17) an annular brake chamber (44) is provided. The battering charge is arranged in the bolt body (31) located in the breech and has a neck (7) with an opening (9) facing towards the barrel to direct propellant gas to the barrel. This structure can be adapted to any size of the firearms, e.g. sharpshooter rifles with range of 4 to 6 kilometres, sky sweepers with an amplitude of 30 to 35 kilometres to combat targets by homing missiles as well as intercontinental missiles with a range of 500 to 1000 kilometres.

Abstract: The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and its optically active enantiomers. (R)-(?)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and (S)-(+)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine. Furthermore, the invention relates to the preparation of N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxyimidoyl chloride, which may be used as an active ingredient of medicaments, and the preparation of the optically active enantiomers of this compound using the compounds of the invention as intermediate substances.

Abstract: The invention relates to N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and its optically active enantiomers. (R)-(−)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine and (S)-(+)-N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxamidine. Furthermore, the invention relates to the preparation of N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboxyimidoyl chloride, which may be used as an active ingredient of medicaments, and the preparation of the optically active enantiomers of this compound using the compounds of the invention as intermediate substances.

Abstract: A pressing machine, particularly a fast operating pressing machine equipped with a pressing head forced into longitudinal jigging motion in a working range over a bench (46) by an eccenter disk (8), having an eccentric shaft, through a crank arm (9). The pressing head (12) has a lower pressing block (13) removable from the work range above the bench (46) and an upper pressing block (14) arranged slideably in relation to the lower and forced into jigging motion by the crank arm (9) and there is a connecting element (15) joining the lower pressing block (13) to the upper pressing block (14). The connection between the upper and lower pressing block (14, 13) can be broken, thereby motion of the lower pressing block (13) can be stopped while the eccentric disk (8), its shaft and any flywheel or similar inertial mass connected with the upper pressing block (14) continues to rotate.

Abstract: A pressing machine, particularly a fast operating pressing machine equipped with a pressing head forced into longitudinal jigging motion in a working range over a bench (46) by an eccenter disk (8), having an eccentric shaft, through a crank arm (9). The pressing head (12) has a lower pressing block (13) removable from the work range above the bench (46) and an upper pressing block (14) arranged slideably in relation to the lower and forced into jigging motion by the crank arm (9) and there is a connecting element (15) joining the lower pressing block (13) to the upper pressing block (14). The connection between the upper and lower pressing block (14, 13) can be broken, thereby motion of the lower pressing block (13) can be stopped while the eccentric disk (8), its shaft and any flywheel or similar inertial mass connected with the upper pressing block (14) continues to rotate.

Abstract: The invention relates to improved manufacture of methylene bis-(dibutyl-dithiocarbamate) with ASTM coulour less than 2, by reacting aqueous solutions of dibutyl amine and sodium hydroxide with carbon disulfide, treating the obtained reaction product with methylene dichloride, followed by vacuum stripping, phase separation and filtration of the precipitated sodium chloride. According to the invention, during reaction with carbon disulfide the temperature of the mixture is kept at or below 15.degree. C. and the vacuum stripping is performed in two steps, first between 45.degree. C. and 100.degree. C. and at a pressure of 5-50 kPa, then phase separation is carried out at a temperature between 35.degree. C. and 50.degree. C., followed by stripping the separated organic phase in vacuum also at a temperature between 45.degree. C. and 100.degree. C. and at a pressure of 5-50 kPa.

Abstract: The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen, hydroxyl or trifluoroacetoxy group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group; andrepresents a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.

Abstract: The invention relates to a novel process for the preparation of aluminum oxide carboxylate polymers containing at most 2% by weight of ester by reacting an aluminum alkoxide of the general formula Al(OR).sub.3, wherein R stands for a C.sub.2-5 alkyl group, dissolved in an aromatic or aliphatic hydrocarbon with a solution of a C.sub.8-22 aliphatic or alicyclic monocarboxylic acid or carboxylic acid mixture and water in a C.sub.2-5 alkanol and removing the alkanol(s).The process according to the invention comprises introducing the solution of the aluminum alkoxide to a tube reactor having a 10 to 200 length/diameter ratio at a temperature exceeding by 15.degree.to 50.degree.C.

Abstract: The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group;R.sup.1 and R.sup.2, which are the same or different, stand for hydrogen or a C.sub.1-4 alkyl group; or one of R.sup.1 and R.sup.2 is hydrogen and the other is phenyl group; or R.sup.1 and R.sup.2 together form a C.sub.4-5 alkylene group;means a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.

Abstract: The invention relates to the novel 2,6-bis(chloromethyloxy-carbonyloxymethyl)pyridine of the formula (I) ##STR1## as well as a process for the preparation of this compound, which is a useful intermediate in the preparation of the anti-atherosclerotic 2,6-bis(hydroxymethyl)pyridine bis(N-methylcarbamate) (pyridinolcarbamate) and other drugs.According to the invention, the compound of the formula (I) is prepared by reacting 2,6-bis(hydroxymethyl)pyridine of the formula (II) ##STR2## with chloromethyl chloroformate of the formula (III) ##STR3## in a polar-aprotic, water-immiscible organic solvent, in the presence of a basic substance between about -30.degree. C. and +10.degree. C.

Abstract: The invention relates to a novel process for the preparations of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond beween the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.

Abstract: New .DELTA..sup.1,3,5 -3-chloro-pregnane derivatives of the general formula (I), ##STR1## wherein X is hydrogen atom, acetyl group or a chloroacetyl group, andY and Z represent hydrogen atom or a halogen atom, with the proviso that at least one of them is other than hydrogen,are prepared by reacting a .DELTA..sup.1,4 -3-oxo-pregnane derivative of the general formula (II), ##STR2## wherein X' is acetyl group or a chloroacetyl group and Y and Z are as defined above, with a chloromethyleneiminium salt of the general formula (III), ##STR3## wherein A.sup.(-) is a salt-forming anion, in an aprotic solvent in the presence of a tertiary base, and, if desired, subjecting the resulting product to hydrolysis.The compounds of the general formula (I) exert antiphlogistic effects and can be used in the therapy for the treatment of inflammations.

Abstract: The invention relates to a novel process for the preparation of pregnane derivatives of formula I, ##STR1## wherein R.sup.1 stands for a methyl or an ethyl group,R.sup.2 represents a hydrogen atom or a methyl group, andX is a hydrogen atom or a formyl or acetyl group, and the bond indicated by a dotted and a continuous line stands for a single or a double bond between the two neighboring carbon atoms.According to the invention a trifluoroacetate ester of formula II, ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, is reacted with formic acid or acetic acid in the presence of a catalytic amount of a mercury salt in a dipolar proton-free or basic solvent. The formyl or acetyl group being in the place of X can be split off in a way known per se.The process provides a novel advantageous method for building up the pregnane side chain characteristic of corticoids.

Abstract: A self-adjusting powder distributor--which is particularly intended for use with alumina calcination apparatus--comprises a casing with a permeable partition, a plurality of outlets, and means for introducing preheated hydrate above the partition and fluidizing air therebelow. The fluidized hydrate withdraws through outlets of the casing for further treatment or partly as final product. The casing is provided with means by which the amounts and mutual ratios of the withdrawing material can be adjusted according to preselected values by altering the cross-sectional flow area or the level of the outlets.

Abstract: A self-adjusting powder distributor--which is particularly intended for use with alumina calcination apparatus--comprises a casing with a permeable partition, a plurality of outlets, and means for introducing preheated hydrate above the partition and fluidizing air therebelow. The fluidized hydrate withdraws through outlets of the casing for further treatment or partly as final product. The casing is provided with means by which the amounts and mutual ratios of the withdrawing material can be adjusted according to preselected values by altering the cross-sectional flow area or the level of the outlets.