Patents by Inventor Jack A. Schmidt

Jack A. Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic amide compounds as cell adhesion inhibitors
    Patent number: 6903075
    Abstract: Compounds of Formula I are antagonists of VLA-4 and/or ?4?7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: June 7, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Philippe L. Durette, Malcolm MacCoss, William K. Hagmann, Sander G. Mills, Richard A. Mumford, Jack A. Schmidt, Gail A. Van Riper
  • Purification of human interleukin-1 species
    Patent number: 4770781
    Abstract: Human interleukin-1 (IL-1) charged species (pI 6.8, 6.0, 5.4 and 5.2) are separated and purified by a rapid and efficient two or three stage chromatographic process. Interleukin-1 species present in concentrated culture fluid from stimulated human mononuclear cells are separated and partially purified by anion exchange high performance liquid chromatography. The pI 5.4 and 5.2 species in addition are partially purified by HPLC gel filtration chromatography. Each of the individual IL-1 species are then finally purified by reverse phase high performance liquid chromatography. This process results in homogenously pure pI 6.8, pI 5.4 and pI 5.2 species while the pI 6.0 species is isolated in a substantially pure form.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: September 13, 1988
    Assignee: Merck & Co., Inc.
    Inventors: Jack A. Schmidt, Patricia M. Cameron, Guadalupe A. Limjuco