Abstract: Compounds of Formula I are antagonists of VLA-4 and/or ?4?7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

Abstract: A display system is provided, the system including an illumination source configured to produce light and direct light along an optical path, a plurality of color filters disposed in the optical path configured to generate a plurality of colored light beams, and a spatial light modulator disposed in the optical path adapted to receive and adjust the colored light beams to produce an image.

Abstract: A dust tolerant scanner without a transparent plate to support objects scanned by its media scan assembly. Other dust or debris collecting surfaces in the optical path of the scanner are positioned as far away as possible from an object focal plane of the media scan assembly. The media scan assembly includes upper and lower document feeder portions which define a media path adjacent to a reference surface of the upper portion. The lower document feeder portion includes a media conformance member which positions pieces of media against the reference surface as the pieces of media are advanced along the media path. The media conformance member includes ramp portions and an aperture which provides an optical path between the object focal plane and a sensor focal plane within the scanner.

Abstract: A dust tolerant scanner without a transparent plate to support objects scanned by its media scan assembly. Other dust or debris collecting surfaces in the optical path of the scanner are positioned as far away as possible from an object focal plane of the media scan assembly. The media scan assembly includes upper and lower document feeder portions which define a media path adjacent to a reference surface of the upper portion. The lower document feeder portion includes a media conformance member which positions pieces of media against the reference surface as the pieces of media are advanced along the media path. The media conformance member includes ramp portions and an aperture which provides an optical path between the object focal plane and a sensor focal plane within the scanner.

Abstract: Human interleukin-1 (IL-1) charged species (pI 6.8, 6.0, 5.4 and 5.2) are separated and purified by a rapid and efficient two or three stage chromatographic process. Interleukin-1 species present in concentrated culture fluid from stimulated human mononuclear cells are separated and partially purified by anion exchange high performance liquid chromatography. The pI 5.4 and 5.2 species in addition are partially purified by HPLC gel filtration chromatography. Each of the individual IL-1 species are then finally purified by reverse phase high performance liquid chromatography. This process results in homogenously pure pI 6.8, pI 5.4 and pI 5.2 species while the pI 6.0 species is isolated in a substantially pure form.