Patents by Inventor Jacob A. Flagle

Jacob A. Flagle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8128682
    Abstract: Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodelable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: March 6, 2012
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian C. Case, Jacob A. Flagle, Ram H. Paul, Jr., Sean D. Chambers
  • Publication number: 20110295233
    Abstract: Described are methods, devices, and systems for occluding or ablating vascular vessels. Noninvasive procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous valve insufficiency. Further described is the cooperative use of an angiogenic remodelable material with one or more sclerosing agents to cause closure of a targeted bodily vessel.
    Type: Application
    Filed: August 10, 2011
    Publication date: December 1, 2011
    Inventors: Brian L. Bates, Ram H. Paul, Jacob A. Flagle
  • Patent number: 8066733
    Abstract: Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: November 29, 2011
    Assignee: Cook Incorporated
    Inventors: Ram H. Paul, Brian C. Case, Jacob A. Flagle
  • Patent number: 8066732
    Abstract: Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.
    Type: Grant
    Filed: December 29, 2005
    Date of Patent: November 29, 2011
    Assignee: Cook Incorporated
    Inventors: Ram H. Paul, Brian C. Case, Jacob A. Flagle
  • Patent number: 8029560
    Abstract: Described are methods, devices, and systems for occluding or ablating vascular vessels. Noninvasive procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous valve insufficiency. Further described is the cooperative use of an angiogenic remodelable material with one or more sclerosing agents to cause closure of a targeted bodily vessel.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: October 4, 2011
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Ram H. Paul, Jacob A. Flagle
  • Publication number: 20110224484
    Abstract: This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
    Type: Application
    Filed: March 15, 2011
    Publication date: September 15, 2011
    Inventors: Brian C. Case, Michael C. Hiles, Jacob A. Flagle, F. Joseph Obermiller, Umesh H. Patel
  • Publication number: 20110171181
    Abstract: This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
    Type: Application
    Filed: March 15, 2011
    Publication date: July 14, 2011
    Inventors: Brian C. Case, Michael C. Hiles, Jacob A. Flagle, F. Joseph Obermiller, Umesh H. Patel
  • Patent number: 7955376
    Abstract: A medical device comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: June 7, 2011
    Assignee: Cook Medical Technologies LLC
    Inventors: Thomas A. Osborne, Brian C. Case, Jacob A. Flagle, Andrew K. Hoffa, Michael L. Garrison
  • Publication number: 20110112621
    Abstract: Described are percutaneous vascular valves free of attached support structures and deployment systems and methods for providing attachment of the valves within a vascular vessel.
    Type: Application
    Filed: January 18, 2011
    Publication date: May 12, 2011
    Inventors: Brian C. Case, Charles W. Agnew, Jacob A. Flagle
  • Patent number: 7909862
    Abstract: Methods and devices for delivering and deploying expandable intraluminal medical devices at a desired point of treatment within a body vessel are provided. A delivery device is provided, inserted into a body vessel, and navigated through the vessel to place an associated expandable intraluminal medical device at a desired point of treatment. Once the desired location is reached, an elongate member on which the expandable intraluminal medical device is disposed is spaced from a wall surface of the body vessel using an expandable wire basket, balloon, or other suitable structure. The expandable intraluminal medical device is deployed from the delivery system, which can ultimately be withdrawn from the body vessel.
    Type: Grant
    Filed: March 19, 2004
    Date of Patent: March 22, 2011
    Assignee: Cook Medical Technologies LLC
    Inventors: Michael L. Garrison, Brian C. Case, Andrew K. Hoffa, Jacob A. Flagle, Dusan Pavcnik
  • Patent number: 7905826
    Abstract: This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: March 15, 2011
    Assignee: Cook Incorporated
    Inventors: Brian C. Case, Michael C. Hiles, Jacob A. Flagle, F. Joseph Obermiller, Umesh H. Patel
  • Patent number: 7871434
    Abstract: Described are percutaneous vascular valves (11) free of attached support structures and deployment systems (31) and methods for providing attachment of the valves within a vascular vessel.
    Type: Grant
    Filed: April 1, 2004
    Date of Patent: January 18, 2011
    Assignee: Cook Incorporated
    Inventors: Brian C. Case, Charles W. Agnew, Jacob A. Flagle
  • Patent number: 7871430
    Abstract: A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. The inner member extends through the medical device in the device-containing region, includes a proximal portion (18) with a sufficiently large diameter to prevent longitudinal movement of the device as the catheter is retracted during deployment, and centers the device upon release from the distal catheter end during deployment.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: January 18, 2011
    Assignees: Cook Incorporated, Oregon Health & Science University
    Inventors: Dusan Pavcnik, Christopher G. Dixon, Jacob A. Flagle, Mike Garrison, Andrew K. Hoffa, Ray Leonard, II, Brian C. Case
  • Patent number: 7833267
    Abstract: Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
    Type: Grant
    Filed: October 24, 2008
    Date of Patent: November 16, 2010
    Assignee: Cook Incorporated
    Inventors: Jacob A. Flagle, Brian C. Case
  • Publication number: 20100286719
    Abstract: Valvulotome devices and methods are provided. Valvulotome devices include one or more valvulotome arms that have a u-shaped curved body with opposing arms and a base portion that extends between the arms. The valvulotome arm defines a notch open at one end on one of the arms and extending into the base portion of the u-shaped curved body. The notch defines an angled surface that provides a cutting edge. Methods of making valvulotome devices are also described.
    Type: Application
    Filed: May 17, 2010
    Publication date: November 11, 2010
    Inventors: Ram H. Paul, Brian C. Case, Jacob A. Flagle
  • Publication number: 20100280586
    Abstract: Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodellable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
    Type: Application
    Filed: May 11, 2010
    Publication date: November 4, 2010
    Applicant: COOK INCORPORATED
    Inventors: Brian C. Case, Jacob A. Flagle, Ram H. Paul, JR., Sean D. Chambers
  • Patent number: 7744621
    Abstract: Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: June 29, 2010
    Assignee: Cook Incorporated
    Inventors: Ram H. Paul, Jacob A. Flagle, Brian C. Case
  • Publication number: 20100131055
    Abstract: An expandable venous valve having a support structure configured to enlarge the area adjacent the valve structure. The enlarged pocket areas can be created by forming an artificial sinus adjacent the valve structure in an unsupported section of vessel wall between two support frame sections.
    Type: Application
    Filed: November 9, 2009
    Publication date: May 27, 2010
    Applicant: COOK INCORPORATED
    Inventors: Brian C. Case, Michael L. Garrison, Andrew Hoffa, Darin G. Schaeffer, Jacob A. Flagle
  • Patent number: 7717951
    Abstract: Delivery systems, methods of making delivery systems, and methods of treatment are provided. A delivery system according to the invention facilitates a visual inspection of an intraluminal medical device included in the delivery system.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: May 18, 2010
    Assignee: Cook Incorporated
    Inventors: Jacob A. Flagle, Brian C. Case, Andrew K. Hoffa, Michael L. Garrison
  • Patent number: 7717930
    Abstract: Valvulotome devices comprising a cutting edge are provided. Some valvulotome devices incisably engage a venous valve leaflet within a body vessel while at least a portion of the cutting edge is oriented substantially parallel to the longitudinal axis of the valvulotome device. Valvulotome devices are preferably configured to slidably engage a venous valve leaflet upon translation of the valvulotome device along the longitudinal axis of a body vessel. A valvulotome device can further comprise one or more valvulotome arms of variable lengths and dimensions. In some embodiments, the valvulotome device can be self expanding. Embodiments of the invention also provide delivery systems comprising a valvulotome device. The present invention also provides for methods of using a valvulotome device. Kits comprising a valvulotome device are also provided.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: May 18, 2010
    Assignee: Cook Incorporated
    Inventors: Ram H. Paul, Jr., Brian C. Case, Jacob A. Flagle