Patents by Inventor Jacob A. WOLF
Jacob A. WOLF has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11970538Abstract: The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.Type: GrantFiled: May 20, 2021Date of Patent: April 30, 2024Assignee: COMPASS THERAPEUTICS LLCInventors: Bing Gong, Rachel Rennard, Amanda Frank Oliphant, Cheuk Lun Leung, Benjamin Jacob Wolf, Ugur Eskiocak, Pearl Bakhru, Diana I. Albu
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Publication number: 20240108268Abstract: An automated urine-output-measurement system can include single-patient equipment and/or multi-patient equipment. The single-patient equipment can include a urinary catheter and a urine-collection system. The urine-collection system can include drainage tubing and a drainage receptacle. The multi-patient equipment can include a urine monitor. The urine monitor can include a housing having a cavity configured to completely encompass the drainage receptacle, a urine measurement device configured to measure urine output into the drainage receptacle, and an integrated display screen configured to display patient information including measurements of the urine output. A method of the automated urine-output-measurement system can include placing the drainage receptacle in the urine monitor of the automated urine-output-measurement system, and confirming a volume of urine in the drainage receptacle with that indicated on the urine monitor once a patient has produced urine.Type: ApplicationFiled: December 13, 2023Publication date: April 4, 2024Inventors: Steven P. Woodard, Jacob Wolf, Edward G. Solomon, Russell Ford, William Welch, Mansour A. Saleki
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Publication number: 20240102044Abstract: Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.Type: ApplicationFiled: March 27, 2023Publication date: March 28, 2024Applicant: MiNK Therapeutics, Inc.Inventors: Marc van Dijk, Volker Seibert, Cornelia Anne Mundt, Arthur Andrew Hurwitz, Mark Adrian Exley, Benjamin Jacob Wolf, Daniel Leventhal, Sébastien Lalevée, Reed Masakayan
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Patent number: 11911160Abstract: An automated urine-output-measurement system can include single-patient equipment and multi-patient equipment. The single-patient equipment can include a urinary catheter and a urine-collection system. The urine-collection system can include drainage tubing and a drainage receptacle. The multi-patient equipment can include a urine monitor. The urine monitor can include a housing having a cavity configured to house the drainage receptacle, a urine-measurement means for measuring urine-output into the drainage receptacle, and an integrated display screen configured to display patient information including measurements of the urine output. A method of the automated urine-output-measurement system can include placing the drainage receptacle in the urine monitor of the automated urine-output-measurement system, and confirming a volume of urine in the drainage receptacle with that indicated on the urine monitor once a patient has produced urine.Type: GrantFiled: August 8, 2019Date of Patent: February 27, 2024Assignee: C. R. Bard, Inc.Inventors: Steven P. Woodard, Jacob Wolf, Edward G. Solomon, Russell Ford, William Welch, Mansour A. Saleki
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Patent number: 11874286Abstract: Systems and techniques for detecting a target substance, such as THC, in a breath constituent sample are provided.Type: GrantFiled: March 15, 2021Date of Patent: January 16, 2024Assignee: Hound Labs, Inc.Inventors: Michael Scott Lynn, Hamilton Roger Tang, Kate L. Bechtel, Peter A. Holst, Jacob A. Wolf, Kevin M. Limtao
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Publication number: 20230321421Abstract: A hemostasis valve device includes a valve body having an open first end and an open second end with a main lumen extending from the open first end to the open second end. The valve includes a valve member disposed within the main lumen of the valve body at or proximate to the open first end, the valve member having an open position and a closed position. An actuator is disposed between the valve member and the open second end. The actuator is configured to move the valve member between the open position and the closed position.Type: ApplicationFiled: June 12, 2023Publication date: October 12, 2023Inventors: Joseph Borrello, Jacob Wolf, Alexis Bruhat, Thomas Oxley, Anthony Costa
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Patent number: 11718658Abstract: Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.Type: GrantFiled: March 3, 2020Date of Patent: August 8, 2023Assignee: MiNK Therapeutics, Inc.Inventors: Marc van Dijk, Ekaterina Vladimirovna Breous-Nystrom, Alessandra Franchino, Sébastien Lalevée, Arthur Andrew Hurwitz, Mark Adrian Exley, Benjamin Jacob Wolf
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Patent number: 11613764Abstract: Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.Type: GrantFiled: July 15, 2019Date of Patent: March 28, 2023Assignee: MiNK Therapeutics, Inc.Inventors: Marc van Dijk, Volker Seibert, Cornelia Anne Mundt, Arthur Andrew Hurwitz, Mark Adrian Exley, Benjamin Jacob Wolf, Daniel Leventhal, Sébastien Lalevée, Reed Masakayan
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Publication number: 20230060285Abstract: A wind turbine is optimized for low and high speed winds with sensing to measure climate change gases using IoT connectivity with long life serviceability. The wind turbine has an egg-shaped or elliptical profile that performs well in any physical orientation, enabling plural turbines in either horizontal or vertical stacks. A wildlife net is applied to the intake sides of the wind turbine, where the profile secures the net against displacement.Type: ApplicationFiled: August 28, 2022Publication date: March 2, 2023Applicant: Anew Energy LLCInventors: Patrick Conarro, Tate Smith, Jacob Wolf
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Publication number: 20220162696Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: December 6, 2021Publication date: May 26, 2022Inventors: Nathan BECKETT, Gilad ALMOGY, Nathan CASWELL, Jacob A. WOLF, Kristopher BARBEE, Denis PRISTINSKI, Mark PRATT, Gene POLOVY, Osip SCHWARTZ, Stephanie KUBECKA, Steven MENCHEN, Joseph ANTHONY, Jose Martin SOSA, Phillip You Fai LEE
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Patent number: 11268143Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: GrantFiled: May 5, 2021Date of Patent: March 8, 2022Assignee: Ultima Genomics, Inc.Inventors: Nathan Beckett, Gilad Almogy, Nathan Caswell, Jacob A. Wolf, Kristopher Barbee, Denis Pristinski, Mark Pratt, Gene Polovy, Osip Schwartz, Stephanie Kubecka, Steven Menchen, Joseph Anthony, Jose Martin Sosa, Phillip You Fai Lee
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Publication number: 20220064727Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: September 14, 2021Publication date: March 3, 2022Inventors: Gilad Almogy, Nathan Beckett, Jacob A. Wolf, Nathan Caswell, Joseph Anthony, Jose Martin Sosa, Phillip Lee, Stephanie Kubecka
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Patent number: 11155868Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: GrantFiled: January 22, 2021Date of Patent: October 26, 2021Assignee: ULTIMA GENOMICS, INC.Inventors: Gilad Almogy, Nathan Beckett, Jacob A. Wolf, Nathan Caswell, Joseph Anthony, Jose Martin Sosa, Phillip Lee, Stephanie Kubecka
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Publication number: 20210298653Abstract: An automated urine-output-measurement system can include single-patient equipment and multi-patient equipment. The single-patient equipment can include a urinary catheter and a urine-collection system. The urine-collection system can include drainage tubing and a drainage receptacle. The multi-patient equipment can include a urine monitor. The urine monitor can include a housing having a cavity configured to house the drainage receptacle, a urine-measurement means for measuring urine-output into the drainage receptacle, and an integrated display screen configured to display patient information including measurements of the urine output. A method of the automated urine-output-measurement system can include placing the drainage receptacle in the urine monitor of the automated urine-output-measurement system, and confirming a volume of urine in the drainage receptacle with that indicated on the urine monitor once a patient has produced urine.Type: ApplicationFiled: August 8, 2019Publication date: September 30, 2021Applicants: C. R. Bard, Inc., C. R. Bard, Inc.Inventors: Steven P. Woodard, Jacob Wolf, Edward G. Solomon, Russell Ford, William Welch, Mansour A. Saleki
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Publication number: 20210284736Abstract: The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.Type: ApplicationFiled: May 20, 2021Publication date: September 16, 2021Inventors: Bing Gong, Rachel Rennard, Amanda Frank Oliphant, Cheuk Lun Leung, Benjamin Jacob Wolf, Ugur Eskiocak, Pearl Bakhru, Diana I. Albu
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Publication number: 20210277464Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: May 5, 2021Publication date: September 9, 2021Inventors: Nathan BECKETT, Gilad ALMOGY, Nathan CASWELL, Jacob A. WOLF, Kristopher BARBEE, Denis PRISTINSKI, Mark PRATT, Gene POLOVY, Osip SCHWARTZ, Stephanie KUBECKA, Steven MENCHEN, Joseph ANTHONY, Jose Martin SOSA, Phillip You Fai LEE
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Publication number: 20210199647Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: February 22, 2021Publication date: July 1, 2021Inventors: Nathan BECKETT, Gilad ALMOGY, Nathan CASWELL, Jacob A. WOLF, Kristopher BARBEE, Denis PRISTINSKI, Mark PRATT, Gene POLOVY, Osip SCHWARTZ, Stephanie KUBECKA, Steven MENCHEN, Joseph ANTHONY, Jose Martin SOSA, Phillip You Fai LEE
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Patent number: 11046769Abstract: The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.Type: GrantFiled: November 13, 2019Date of Patent: June 29, 2021Assignee: COMPASS THERAPEUTICS LLCInventors: Bing Gong, Rachel Rennard, Amanda Frank Oliphant, Cheuk Lun Leung, Benjamin Jacob Wolf, Ugur Eskiocak, Pearl Bakhru, Diana I. Albu
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Patent number: D998172Type: GrantFiled: March 12, 2021Date of Patent: September 5, 2023Assignee: ULTIMA GENOMICS, INC.Inventors: Jacob Wolf, Nathan Beckett
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Patent number: D1023338Type: GrantFiled: February 18, 2021Date of Patent: April 16, 2024Assignee: Ultima Genomics, Inc.Inventors: Nathan Beckett, Jacob Wolf, Keith Allen, Ryan Rosenfeld, Anh Nguyen, Hoang Nguyen