Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Abstract: Systems and techniques for detecting a target substance, such as THC, in a breath constituent sample are provided.

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Abstract: Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.

Abstract: The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.

Abstract: Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

Abstract: Systems and techniques for detecting a target substance, such as THC, in a breath constituent sample are provided.

Abstract: Systems and techniques for detecting a target substance, such as THC, in a breath constituent sample are provided.

Abstract: Wrist, hand, or arm support devices are provided. The support devices include a support member having a top surface and a front surface. The top surface is oriented at either a parallel angle or a non-parallel angle with respect to a work surface. The front surface curves upon itself to form either a symmetric or an asymmetric arc. Preferred versions of the support devices described herein include at least one of a top surface oriented at a non-parallel angle with respect to the work surface or a front surface that curves upon itself to define an asymmetric arc. Mounting members for connecting the support member to an operating surface are also provided. The support devices described herein permit an operator to comfortably rest his or her hand on the support devices while directing procedures toward non-centered portions of work objects.

Abstract: A mechanism and method for precisely arranging two or more optical elements, such as those incorporated into photoelastic modulators (PEMs), at a specific angular orientation. The method includes supporting one optical element in an annular mounting member that has an optic axis, and supporting other optical elements in other annular mounting members that have optic axes, and concentrically stacking together the two or more mounting members about a central axis in a manner such that one mounting member may be rotated relative to the others about the central axis and such that the optic axes of the mounting members define an optics angle, and rotating one mounting member relative to the others to define the specific angular orientation of the optical elements.

Abstract: A mechanism and method for precisely arranging two or more optical elements, such as those incorporated into photoelastic modulators (PEMs), at a specific angular orientation. The method includes supporting one optical element in an annular mounting member that has an optic axis, and supporting other optical elements in other annular mounting members that have optic axes, and concentrically stacking together the two or more mounting members about a central axis in a manner such that one mounting member may be rotated relative to the others about the central axis and such that the optic axes of the mounting members define an optics angle, and rotating one mounting member relative to the others to define the specific angular orientation of the optical elements.

Abstract: Wrist, hand, or arm support devices are provided. The support devices include a support member having a top surface and a front surface. The top surface is oriented at either a parallel angle or a non-parallel angle with respect to a work surface. The front surface curves upon itself to form either a symmetric or an asymmetric arc. Preferred versions of the support devices described herein include at least one of a top surface oriented at a non-parallel angle with respect to the work surface or a front surface that curves upon itself to define an asymmetric arc. Mounting members for connecting the support member to an operating surface are also provided. The support devices described herein permit an operator to comfortably rest his or her hand on the support devices while directing procedures toward non-centered portions of work objects.