Patents by Inventor Jacob Bradley Schwarz

Jacob Bradley Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20240051917
    Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.
    Type: Application
    Filed: May 15, 2023
    Publication date: February 15, 2024
    Inventors: Anton Fran Joseph FLIRI, Randall J. GALLUSCHUN, Christopher John O'DONNELL, Jacob Bradley SCHWARZ, Barbara Eileen SEGELSTEIN
  • INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS
    Publication number: 20230148214
    Abstract: The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.
    Type: Application
    Filed: March 5, 2021
    Publication date: May 11, 2023
    Inventors: Albert W. Garofalo, Jacob Bradley Schwarz, Fabio Maria Sabbatini, Silvia Bernardi, Marco Migliore, Federica Budassi, Claudia Beato
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20230133817
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: December 8, 2022
    Publication date: May 4, 2023
    Inventors: Yongsheng Chen, Peter Andrew Smith, Tuker Curran Roberts, Robert I. Higuchi, Prasuna Paraselli, Michael F.T Koehler, Jacob Bradley Schwarz, James John Crawford, Cuong Q. Ly, Emily J. Hanan, Huiyong Hu, Zhiyong Yu
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20230133667
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: October 18, 2022
    Publication date: May 4, 2023
    Inventors: Peter Andrew Smith, Tucker Curran Roberts, Robert I. Higuchi, Prasuna Paraselli, Michael F. T. Koehler, Jacob Bradley Schwarz, James John Crawford, Cuong Q. Ly, Emily J. Hanan, Huiyong Hu, Yongsheng Chen, Zhiyong Yu, Paul Colin Michael Winship, Calum MacCleod, Toby Blench
  • CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20230139321
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Application
    Filed: May 20, 2022
    Publication date: May 4, 2023
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS
    Publication number: 20230077268
    Abstract: The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.
    Type: Application
    Filed: May 11, 2022
    Publication date: March 9, 2023
    Inventors: Albert W. Garofalo, Stéphane De Lombaert, Jacob Bradley Schwarz, Daniele Andreotti, Fabio Maria Sabbatini, Elena Serra, Silvia Bernardi, Marco Migliore, Federica Budassi, Claudia Beato
  • PHENOXY-PYRIDYL-PYRIMIDINE COMPOUNDS AND METHODS OF USE
    Publication number: 20230057166
    Abstract: Described herein are phenoxy-pyridyl-pyrimidine compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula I structure or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 23, 2023
    Inventors: Marie-Gabrielle Braun, Cuong Q. Ly, Georgette Castanedo, Paul Gibbons, Wendy Lee, Joachim Rudolph, Nicole Alice Blaquiere, Jacob Bradley Schwarz, Ramsay Beveridge, Jean-Philippe Leclerc, Alexandre Lemire, Leo Fu
  • Indazoles and azaindazoles as LRRK2 inhibitors
    Patent number: 11427558
    Abstract: The present invention is directed to indazole and azaindazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: August 30, 2022
    Assignee: ESCAPE Bio, Inc.
    Inventors: Albert W. Garofalo, Stéphane De Lombaert, Jacob Bradley Schwarz, Daniele Andreotti, Fabio Maria Sabbatini, Elena Serra, Silvia Bernardi, Marco Migliore, Federica Budassi, Claudia Beato
  • Chemokine receptor modulators and uses thereof
    Patent number: 11384064
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: July 12, 2022
    Assignee: RAPT Therapeutics, Inc.
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • PYRIMIDINYL-HETEROARYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF USE
    Publication number: 20220048888
    Abstract: Described herein are phenoxy-pyridazinyl-pyrimidine or phenoxy-pyrimidinyl-pyrimidine compounds and pharmaceutically acceptable salts thereof for use in the treatment of Ire1-mediated diseases and cancer.
    Type: Application
    Filed: September 11, 2019
    Publication date: February 17, 2022
    Inventors: Marie-Gabrielle Braun, Paul Gibbons, Wendy Lee, Cuong Q. Ly, Joachim Rudolph, Jacob Bradley Schwarz, Avi Ashkenazi, Ramsay Beveridge, Liang Zhao, Alexandre Lemire, Leo Fu, Kwong Wah Lai, Fei Wang
  • Chemokine receptor modulators and uses thereof
    Patent number: 11192879
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: December 7, 2021
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF
    Publication number: 20210317134
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Application
    Filed: March 5, 2020
    Publication date: October 14, 2021
    Inventors: Jacob Bradley Schwarz, John Michael Ketcham, Maureen Kay Reilly, Berenger Biannic, Minna Hue Thanh Bui, Dennis X. Hu, David Juergen Wustrow, Emily Karbarz, Xinping Han, Grant Shibuya, Jack Maung, Maksim Osipov
  • Ubiquitin-specific-processing protease 7 (USP7) modulators and uses thereof
    Patent number: 11084829
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: August 10, 2021
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Berenger Biannic, Xinping Han, Dennis X. Hu, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, David Juergen Wustrow, Kyle Young, Gene Cutler, Yamini Ohol-Gupta
  • Macrocyclic broad spectrum antibiotics
    Patent number: 11072635
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: July 27, 2021
    Assignees: RQX Pharmaceuticals, Inc., Genentech, Inc.
    Inventors: Yongsheng Chen, Peter Andrew Smith, Tucker Curran Roberts, Robert I. Higuchi, Prasuna Paraselli, Michael F. T. Koehler, Jacob Bradley Schwarz, James John Crawford, Cuong Q. Ly, Huiyong Hu, Zhiyong Yu
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20210198316
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: August 13, 2019
    Publication date: July 1, 2021
    Inventors: Peter Andrew SMITH, Tucker Curran ROBERTS, Robert I. HIGUCHI, Prasuna PARASELLI, Michael F. T. KOEHLER, Jacob Bradley SCHWARZ, James John CRAWFORD, Cuong Q. LY, Emily J. HANAN, Huiyong HU, Yongsheng CHEN, Zhiyong YU, Paul Colin Michael WINSHIP, Calum McCleod, Toby Blench
  • PROCESSES FOR PREPARING AN S1P-RECEPTOR MODULATOR
    Publication number: 20210139503
    Abstract: This application relates to processes for preparing an S1P-receptor modulator, which is useful in the treatment of diseases or disorders associated with activity of S1P, including CNS disorders.
    Type: Application
    Filed: October 30, 2020
    Publication date: May 13, 2021
    Inventors: Stéphane De Lombaert, Jonathon Daryll Schwarz Holt, Ana Rosario Mollo Sarno, Jacob Bradley Schwarz, Michael A. Christie, Edward L. Ciolkowski, Zenghong Zhang
  • CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20200339539
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 29, 2020
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20200325117
    Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of certain chemokine receptor activity.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 15, 2020
    Inventors: Jeffrey J. Jackson, John Michael Ketcham, Akinori Okano, Maureen Kay Reilly, Omar Robles-Resendiz, Jacob Bradley Schwarz, Parcharee Tivitmahaisoon, David Juergen Wustrow, Ashkaan Younai, Mikhail Zibinsky
  • MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
    Publication number: 20200239519
    Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
    Type: Application
    Filed: November 21, 2016
    Publication date: July 30, 2020
    Inventors: Yongsheng CHEN, Peter Andrew SMITH, Tucker Curran ROBERTS, Robert I. HIGUCHI, Prasuna PARASELLI, Michael F. T. KOEHLER, Jacob Bradley SCHWARZ, James John CRAWFORD, Cuong Q. LY, Huiyong HU, Zhiyong YU
  • Ubiquitin-specific-processing protease 7 (USP7) modulators and uses thereof
    Patent number: 10722514
    Abstract: Disclosed herein, inter alia, compounds and methods of use thereof for the modulation of USP7 activity.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: July 28, 2020
    Assignee: RAPT THERAPEUTICS, INC.
    Inventors: Berenger Biannic, Xinping Han, Dennis X. Hu, John Michael Ketcham, Paul Robert Leger, Jack Maung, Akinori Okano, Jacob Bradley Schwarz, Grant Shibuya, David Juergen Wustrow, Kyle Young