Patents by Inventor Jacob Bradley Schwarz

Jacob Bradley Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrazole and oxadiazolone substituted ?-amino acid derivatives
    Patent number: 7250433
    Abstract: This invention relates to novel tetrazole and oxadiazalone ?-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: July 31, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Nancy Sue Barta, Norman Lloyd Colbry, Raymond Hudack, Jr., Kristin Knapp Lin, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow, Zhijian Zhu
  • Amino acids with affinity for the ?2?-protein
    Patent number: 7179934
    Abstract: Certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed are methods of making the ?-amino acids.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: February 20, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Peter Garth Blazecka, Joseph Richard Bozelak, Norman Lloyd Colbry, Timothy Thomas Curran, Annise Paige Goodman, Kevin E. Henegar, Garrett Hoge, Paul D. Johnson, Augustine Tobi Osuma, Mark Stephen Plummer, Jacob Bradley Schwarz, Derek Clinton Vrieze, Ji Zhang
  • Amino acids with affinity for the ?-2-delta-protein
    Patent number: 7064147
    Abstract: This invention relates to certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: June 20, 2006
    Assignee: Warner-Lambert Company
    Inventors: Nancy Sue Barta, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow
  • Cycloproply ?-amino acid derivatives
    Patent number: 7030267
    Abstract: This invention relates to novel cyclopropyl ?-amino acids derivatives of the formula wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: April 18, 2006
    Assignee: Warner-Lambert Company, LLC
    Inventors: Jacob Bradley Schwarz, David Juergen Wustrow
  • Amino acids with affinity for the alpha2delta-protein
    Publication number: 20050272783
    Abstract: This invention relates to certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric pain and other disorders.
    Type: Application
    Filed: July 1, 2005
    Publication date: December 8, 2005
    Inventors: Nancy Sue Barta, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow
  • Cyclopropyl beta-amino acid derivatives
    Publication number: 20040147608
    Abstract: This invention relates to novel cyclopropyl &bgr;-amino acids derivatives of the formula 1
    Type: Application
    Filed: January 16, 2004
    Publication date: July 29, 2004
    Inventors: Jacob Bradley Schwarz, David Juergen Wustrow
  • Mono-and disubstituted 3-propyl gamma-aminobutyric acids
    Publication number: 20040063789
    Abstract: The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I 1
    Type: Application
    Filed: September 29, 2003
    Publication date: April 1, 2004
    Inventors: Thomas Richard Belliotti, Justin Stephen Bryans, Ihoezo Victor Ekhato, Augustine Tobi Osuma, Robert Michael Schelkun, Jacob Bradley Schwarz, Andrew John Thorpe, Lawrence David Wise, David Juergen Wustrow, Po-Wai Yuen
  • Mono-and disubstituted 3-propyl gamma-aminobutyric acids
    Patent number: 6642398
    Abstract: The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: November 4, 2003
    Assignee: Warner-Lambert Company
    Inventors: Thomas Richard Belliotti, Justin Stephen Bryans, Ihoezo Victor Ekhato, Augustine Tobi Osuma, Robert Michael Schelkun, Jacob Bradley Schwarz, Andrew John Thorpe, Lawrence David Wise, David Juergen Wustrow, Po-Wai Yuen
  • Amino acids with affinity for the alpha-2-delta-protein
    Publication number: 20030195251
    Abstract: This invention relates to certain &bgr;-amino acids that bind to the alpha-2-delta (&agr;2&dgr;) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
    Type: Application
    Filed: March 27, 2003
    Publication date: October 16, 2003
    Inventors: Nancy Sue Barta, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow
  • Mono-and disubstituted 3-propyl gamma-aminobutyric acids
    Publication number: 20030181523
    Abstract: The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I 1
    Type: Application
    Filed: December 20, 2002
    Publication date: September 25, 2003
    Inventors: Thomas Richard Belliotti, Justin Stephen Bryans, Ihoezo Victor Ekhato, Augustine Tobi Osuma, Robert Michael Schelkun, Jacob Bradley Schwarz, Andrew John Thorpe, Lawrence David Wise, David Juergen Wustrow, Po-Wai Yuen