Abstract: Articles (e.g., lateral flow assays) and methods for the detection of an analyte are generally described. The assays may involve the use of a network which blocks or restricts flow in the assay, e.g., due to formation of an interconnect network or lattice.

Abstract: The present invention relates to boron containing compounds of Formula (IA): that inhibit phosphodiesterase 4 (PDE4). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating diseases, conditions, or disorders ameliorated by inhibition of PDE4.

Abstract: A delivery device for a collapsible heart valve includes an operating handle and a catheter assembly. The operating handle includes a frame defining a movement space therein, a carriage assembly moveable in a longitudinal direction within the movement space, and a coupler having locked and unlocked conditions, the coupler being operatively connected to the carriage assembly for movement therewith. The catheter assembly includes a shaft around which a valve-receiving compartment is defined, the shaft being operatively connected to one of the frame or the carriage assembly, and a distal sheath operatively connected to the carriage assembly for movement therewith between a closed condition adapted to maintain the valve in the compartment and an open condition adapted to fully deploy the valve.

Abstract: A prosthetic heart valve includes a collapsible and expandable stent extending in a longitudinal direction between an inflow end and an outflow end, the stent including a plurality of struts defining a plurality of cells, and a plurality of commissure attachment features disposed on the stent, each commissure attachment feature having a first end, a second end opposite the first end, and at least two bodies connected via one or more suspension struts, each of the at least two bodies having at least one eyelet.

Abstract: A nozzle for a turbine system includes an airfoil, an inner sidewall, and an outer sidewall. Each of the inner sidewall and outer sidewall includes a peripheral edge defining a pressure side slash face, a suction side slash face, a leading edge face, and a trailing edge face. At least one of the inner sidewall pressure side slash face, the inner sidewall suction side slash face, the outer sidewall pressure side slash face, or the outer sidewall suction side slash face includes a first swept surface extending at a first angle relative to a nominal slash face angle and a second swept surface extending at a second angle relative to the nominal slash face angle. The first and second swept surfaces meet at an arc having a peak that is circumferentially aligned with a stiffening member extending circumferentially on a respective sidewall.

Abstract: A vacuum tube assembly for removing material is disclosed, including: a vacuum generator configured to generate a vacuum airflow; one or more tubes coupled to the vacuum generator and configured to channel the vacuum airflow; and an actuation mechanism coupled to the one or more tubes, wherein the actuation mechanism is configured to actuate at least one tube from a first position relative to a material stream to a second position relative to the material stream, wherein the first position is farther from the material stream than the second position.

Abstract: A prosthetic heart valve includes a collapsible and expandable stent and a plurality of commissure features disposed on the stent. A collapsible and expandable valve assembly includes a plurality of leaflets connected to the plurality of commissure features, each commissure feature including a body having a proximal end and a distal end. A plurality of eyelets is arranged in rows and columns on the body for distributing load from the plurality of leaflets.

Abstract: A hollow CMC article, a mandrel for forming the article and a method for forming the article are disclosed. The article includes a ply-wrap layer defining a cavity. The ply-wrap layer includes a first face, a second face, a root portion bridging the faces, and a plurality of CMC wrap plies. The root portion defines a terminus of the ply-wrap layer including a cross-sectional conformation consisting of a curve having a single turning point. Each of the plurality of CMC wrap plies are disposed along the first face, wrap over the root portion, and extend along the second face. The hollow article further includes a plurality of CMC lateral plies disposed along the faces.

Abstract: A method of providing customized interaction of a media player based on metadata obtained from an origin server. In one step, the origin server obtains metadata related to an active substream content. The media player is provided a playlist for playing a primary video stream. The playlist includes a request for the metadata, the request being associated with the insertion of the active substream content in the playback of the primary video stream. The origin server receives the request for the metadata from the media player. The origin server inserts the active substream content and metadata segments into the primary video stream. A secondary video stream is obtained after insertion of the active substream content. The origin server provides the metadata to the media player using a metadata storage and a metadata service. The media player customizes the interaction using the metadata during playback of the secondary video stream.

Abstract: A nozzle for a turbine system includes an airfoil, an inner sidewall, and an outer sidewall. Each of the inner sidewall and outer sidewall each includes a peripheral edge defining a pressure side slash face, a suction side slash face, a leading edge face, and a trailing edge face. At least one of the inner sidewall pressure side slash face, the inner sidewall suction side slash face, the outer sidewall pressure side slash face, or the outer sidewall suction side slash face includes a first swept surface extending at a first angle relative to a nominal slash face angle and a second swept surface extending at a second angle relative to the nominal slash face angle. The first and second swept surfaces meet at a joining line that is circumferentially aligned with a stiffening member extending circumferentially on a respective sidewall.

Abstract: A component includes an outer wall that includes an exterior surface, and at least one plenum defined interiorly to the outer wall and configured to receive a cooling fluid therein. The component also includes a coating system disposed on the exterior surface. The coating system has a thickness. The component further includes a plurality of adaptive cooling openings defined in the outer wall. Each of the adaptive cooling openings extends from a first end inflow communication with the at least one plenum, outward through the exterior surface and to a second end covered underneath at least a portion of the thickness of the coating system.

Abstract: A tank mounting adapter is provided that includes a tank adapter disc and a compression nut. The tank adapter disc includes an opening disposed therethrough, which may be sized to receive at least a portion of the support structure of the fluid pump. The compression nut may include a collar with a threaded opening disposed therethrough such that threads of the threaded opening are configured to correspond to threads on the support structure of the fluid pump. The compression nut may be located adjacent the tank adapter disc. The collar may further include a lower portion that extends into the opening of the tank adapter disc. The compression nut may be movable with respect to the tank adapter disc and against the tank adapter disc.

Abstract: A passive-intermodulation-mitigating mounting assembly for a fixture, such as can be affixed to a utility or communications monopole can include a first bracket and a second bracket respectively defining a first through hole and a second through hole. In some examples, a mounting plate supports an antenna or a radio. A fastener can extend through the first through hole and the second through hole, for instance to couple the first bracket with the second bracket to attach the mounting assembly to a fixture. The passive-intermodulation-mitigating mounting assembly can include a bushing that can be inserted into a through hole, and the bushing can physically and electrically isolate the fastener from one or more of the brackets. The isolation of the bushing helps inhibit the passive-intermodulation of the mounting assembly when the fastener extends, via the first bushing, through at least one of the through holes.

Abstract: A turbine nozzle for a gas turbine includes: an airfoil having an airfoil shape having a nominal profile substantially in accordance with at least a portion of Cartesian coordinate values of X, Y and Z set forth in TABLE I. The Cartesian coordinate values are non-dimensional values of from 0% to 100% convertible to distances by multiplying the values by a height of the airfoil expressed in units of distance. The X and Y values are connected by smooth continuing arcs that define airfoil profile sections at each distance Z along at least a portion of the airfoil, and the airfoil profile sections at the Z distances are joined smoothly with one another to form the nominal profile. A trailing edge profile for a turbine nozzle is also disclosed.

Abstract: A method of protecting a gas turbine component for operation in a high temperature environment that includes the gas turbine component including a substrate having a silicon-containing layer, wherein the gas turbine component has a curved surface; forming a flexible mask configured to cover the curved surface of the gas turbine component, the flexible mask including a plurality of slots disposed in a pattern; disposing the flexible mask in direct contact with the curved surface of the gas turbine component; applying a bondcoat onto the flexible mask and the gas turbine component, such that bondcoat fills the plurality of slots and contacts the curved surface; and removing the flexible mask by heat or chemical reaction, such that, after removing the flexible mask, the curved surface of the gas turbine component comprises a patterned bondcoat layer in the pattern defined by the flexible mask.

Abstract: A method of providing customized interaction of a media player based on metadata obtained from an origin server. In one step, the origin server obtains metadata related to an active substream content. The media player is provided a playlist for playing a primary video stream. The playlist includes a request for the metadata, the request being associated with the insertion of the active substream content in the playback of the primary video stream. The origin server receives the request for the metadata from the media player. The origin server inserts the active substream content and metadata segments into the primary video stream. A secondary video stream is obtained after insertion of the active substream content. The origin server provides the metadata to the media player using a metadata storage and a metadata service. The media player customizes the interaction using the metadata during playback of the secondary video stream.

Abstract: A thermodenuder having a main tube with an outer wall, and a heater (23) arranged within the main tube. The heater is arranged in the center of a cross section through the main tube and is spaced apart from the outer wall of the main tube. The main tube has a main axis of extension, and the heater extends parallel to the main axis. The main tube has two openings that are arranged at opposing side faces of the main tube. A channel for an aerosol is arranged within the main tube between the heater and the outer wall and between the two openings. Furthermore, a method for removing semi-volatile material and semi-volatile particles from an aerosol is provided.

Abstract: A passive-intermodulation-mitigating mounting assembly for a fixture, such as can be affixed to a utility or communications monopole can include a first bracket and a second bracket respectively defining a first through hole and a second through hole. In some examples, a mounting plate supports an antenna or a radio. A fastener can extend through the first through hole and the second through hole, for instance to couple the first bracket with the second bracket to attach the mounting assembly to a fixture. The passive-intermodulation-mitigating mounting assembly can include a bushing that can be inserted into a through hole, and the bushing can physically and electrically isolate the fastener from one or more of the brackets. The isolation of the bushing helps inhibit the passive-intermodulation of the mounting assembly when the fastener extends, via the first bushing, through at least one of the through holes.

Abstract: According to one aspect, a medical device comprising may include a proximal end, a distal end, and a shaft extending between the proximal end and the distal end. The medical device may further include a magnetic sensor assembly that may include a magnetic coupler and first and second magnetic sensors, wherein the magnetic coupler is located at the distal end of the medical device and is rigidly affixed to an inner surface of the shaft. The medical device may further include an optical fiber comprised of a plurality of fiber cores extending along a length of the shaft, wherein one or more of the plurality of fiber cores include an optical sensor located at a location along a length of the optical fiber, wherein the optical fiber is rigidly supported within the shaft at a location near the optical sensor.

Abstract: A turbine nozzle for a gas turbine includes: an airfoil having an airfoil shape having a nominal profile substantially in accordance with at least a portion of Cartesian coordinate values of X, Y and Z set forth in TABLE I. The Cartesian coordinate values are non-dimensional values of from 0% to 100% convertible to distances by multiplying the values by a height of the airfoil expressed in units of distance. The X and Y values are connected by smooth continuing arcs that define airfoil profile sections at each distance Z along at least a portion of the airfoil, and the airfoil profile sections at the Z distances are joined smoothly with one another to form the nominal profile. A trailing edge profile for a turbine nozzle is also disclosed.