Abstract: Devices, systems and methods for the treatment of chronic inflammatory disorders that include an implantable microstimulator and an external charger/controller wherein the microstimulator is configured to operate using closed-loop feedback. The feedback for the microstimulator can be electrical activity of the vagus nerve and/or heart sensed by the microstimulator. The feedback can be used to modulate the stimulation duration, intensity, frequency, on-time and off-time.

Abstract: Devices, systems and methods for the treatment of chronic inflammatory disorders that include an implantable microstimulator and an external charger/controller wherein the microstimulator is configured to operate using closed-loop feedback. The feedback for the microstimulator can be electrical activity of the vagus nerve and/or heart sensed by the microstimulator. The feedback can be used to modulate the stimulation duration, intensity, frequency, on-time and off-time.

Abstract: In one embodiment, a method includes determining a fleet-level objective for a vehicle associated with instructing the vehicle to travel a route according to route criteria based on the fleet-level objective. The method includes receiving a ride request from a ride requestor associated with ride criteria including a pick-up location and a drop-off location. The method includes determining that the ride requestor is a passenger for the vehicle to satisfy the fleet-level objective contingent on modifications to the ride criteria. The method includes providing incentives to the ride requestor contingent on acceptance of the modifications to the ride criteria. The method includes, after receiving the acceptance of the modifications to the ride criteria, modifying the ride criteria in accordance with the route criteria. The method includes instructing the vehicle to transport the ride requestor based on the modified ride criteria so as to fulfill the fleet-level objective.

Abstract: In particular embodiments, a computing system may determine a predicted amount of ride requests for a plurality of collectively-managed vehicles and determine an availability of the collectively-managed vehicles to satisfy the predicted amount of ride requests. Subsequent to determining that the availability fails to satisfy one or more predetermined criteria for servicing the predicted amount of ride requests, the system may determine status information associated with the collectively-managed vehicles and determine, based on at least the status information, one or more minimum services for servicing one or more vehicles among the plurality of collectively-managed vehicles at one or more service centers such that the availability satisfies the one or more predetermined criteria. The system may instruct the one or more vehicles that are to receive the one or more minimum services to travel to the one or more service centers to be serviced.

Abstract: Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.

Abstract: In one embodiment, a method includes a computing system receiving information from an autonomous vehicle (AV). Based on the received information, the system may identify a target objective, with an associated target destination, for the AV and determine that the AV is able to transport passengers while furthering the target objective. The system may receive multiple ride requests from ride requestors, respectively. Each of the ride requests is associated with an origination location and a destination location. The system may match the AV with one of the ride requests based on a location of the AV, the target destination of the target objective, and the origination location and destination location associated with the ride request. The system may instruct the AV to perform a transportation task from the origination location to the destination location associated with the ride request, and drive to the target destination after completing the transportation task.

Abstract: A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.

Abstract: In particular embodiments, a computing system may generate a prediction of requests for autonomous vehicles in a fleet of collectively managed autonomous vehicles based on a current condition and a future event, the prediction including a predicted request level and a predicted duration of the request level. The system may receive status information from fleet vehicles and identify a vehicle in need of service. The system may receive status information from service centers and identify a service center to service the vehicle. The system may determine a time at which to service the vehicle at the identified service center based on the generated prediction of requests, schedule the vehicle for service at the identified service center at the determined time, and instruct the vehicle to drive to the service center to be serviced at the determined time. In particular embodiments, the prediction of requests may be generated using machine learning.

Abstract: Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.

Abstract: A nerve cuff for establishing a nerve block on a nerve can have a cuff body with a channel for receiving a nerve, a reservoir for holding a drug, and an elongate opening slit extending the length of the cuff body that can be opened to provide access to the channel and can be closed to enclose the cuff body around the nerve. The nerve cuff can also include an electrode for detecting and measuring electrical signals generated by the nerve. A controller can be used to control delivery of the drug based on the electrical signals generated by the nerve.

Abstract: Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor ?B Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.

Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.

Abstract: In particular embodiments, a computing system may receive an indication of an impaired sensor component from a first autonomous vehicle. The system may identify a sensor type of the impaired sensor component and determine a suitable service center for servicing the sensor type based on one or more criteria. The system may identify a second autonomous vehicle. The second autonomous vehicle has a functional sensor component of the sensor type. The system may send instructions to the second autonomous vehicle to drive to a location of the first autonomous vehicle and share sensor data from the functional sensor component with the first autonomous vehicle. The first autonomous vehicle may be instructed to drive to the service center location using sensor data of the second autonomous vehicle. The second autonomous vehicle may be instructed to drive to the service center location with the first autonomous vehicle.

Abstract: In one embodiment, a method includes a computing system receiving information from an autonomous vehicle (AV). Based on the received information, the system may identify a target objective, with an associated target destination, for the AV and determine that the AV is able to transport passengers while furthering the target objective. The system may receive multiple ride requests from ride requestors, respectively. Each of the ride requests is associated with an origination location and a destination location. The system may match the AV with one of the ride requests based on a location of the AV, the target destination of the target objective, and the origination location and destination location associated with the ride request. The system may instruct the AV to perform a transportation task from the origination location to the destination location associated with the ride request, and drive to the target destination after completing the transportation task.

Abstract: In particular embodiments, a computing system may generate a prediction of requests for autonomous vehicles in a fleet of collectively managed autonomous vehicles based on a current condition and a future event, the prediction including a predicted request level and a predicted duration of the request level. The system may receive status information from fleet vehicles and identify a vehicle in need of service. The system may receive status information from service centers and identify a service center to service the vehicle. The system may determine a time at which to service the vehicle at the identified service center based on the generated prediction of requests, schedule the vehicle for service at the identified service center at the determined time, and instruct the vehicle to drive to the service center to be serviced at the determined time. In particular embodiments, the prediction of requests may be generated using machine learning.

Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be inductively charged and/or communicated with using the external charger. The implant may include a receiving antenna wrapped around the battery and/or the housing of the microstimulator/microregulator and/or may include a high magnetic permeability material in order to serve as a magnetic core for the antenna coil. Wearable inductive chargers/communication devices for inductively communicating with (including charging) an implanted microstimulator are described herein, which may include magnetically conductive material to enhance communication with an implant, including sub-diaphragmatic implants.

Abstract: Systems, devices, and methods for using vagus nerve stimulation to treat demyelination disorders and/or disorder of the blood brain barrier are described. The vagus nerve stimulation therapy described herein is configured to reduce or prevent demyelination and/or promote remyelination to treat various disorders related to demyelination, such as multiple sclerosis. A low duty cycle stimulation protocol with a relatively short on-time and a relatively long off-time can be used.

Abstract: Diagnostic screening tests that can be used to identify if a patient is a good candidates for an implantable vagus nerve stimulation device. One or more analyte, such as a cytokine or inflammatory molecule, can be measured from a blood sample taken prior to implantation of a vagus nerve stimulator to determine the patient's responsiveness to VNS for treatment of an inflammatory disorder.

Abstract: Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation using feedback to adjust the off times between stimulations. In particular, the feedback include an assessment of the level of inflammation by the patient or the healthcare provider, or by measure the level of an inflammatory analyte or biomarker, or by detecting nerve activity correlated with inflammation.

Abstract: An implanted stimulator can deliver a patient-detectable electrical stimulation to remind or prompt a patient to interact with an implanted therapeutic device (e.g., neurostimulator) when a prompting event occurs. For example, the apparatuses and methods described herein may be configured to apply a prompting patient-detectable electrical vagus nerve stimulation to remind a patient that it is time to administer a therapeutic dose. When the therapeutic device is operated in an automatic fashion, the apparatus can also deliver a patient-detectable warning stimulation prior to the therapeutic stimulation to let the patient know that a therapeutic stimulation will be delivered soon thereafter.