Patents by Inventor Jacob Rosenblum Rubens

Jacob Rosenblum Rubens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
    Publication number: 20240108642
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said glycan therapeutics, e.g. in cancer therapy.
    Type: Application
    Filed: December 11, 2023
    Publication date: April 4, 2024
    Inventors: Geoffrey A. VON MALTZAHN, Yvonne J. Yamanaka, Jared Silverman, John Miles Milwid, Jacob Rosenblum Rubens, John M. Gerema
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240084333
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 14, 2024
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240076698
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 7, 2024
    Inventors: Stephen Hoyt Cleaver, Barrett Ethan Steinberg, Jacob Rosenblum Rubens, Robert James Citorik, William Edward Salomon, Zi Jun Wang
  • Methods and compositions relating to chondrisomes from blood products
    Patent number: 11903975
    Abstract: Therapeutic chondrisome and mitoplast compositions and related methods are described.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 20, 2024
    Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center Corporation
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • Methods and compositions relating to chondrisomes from cultured cells
    Patent number: 11903974
    Abstract: Therapeutic chondrisome compositions and related methods are described.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 20, 2024
    Assignees: FLAGSHIP PIONEERING INNOVATIONS V, INC., The Children's Medical Center Corporation
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, David Chess, Kyle Marvin Trudeau, Kiana Mahdaviani, Jacob Feala, James D. McCully, Douglas B. Cowan
  • TISSUE-SPECIFIC METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240042058
    Abstract: The invention provides, inter alia, systems and associated methods, for modifying DNA, such as the genome of a cell. The systems, in certain embodiments, encompass one or more tissue-specific expression-control sequences, such as promoters and microRNA binding sites in addition to a transposase (or a nucleic acid encoding the same) and a template nucleic acid comprising a sequence to be inserted into the genome of a cell, tissue, or subject.
    Type: Application
    Filed: February 25, 2022
    Publication date: February 8, 2024
    Inventors: Robert James Citorik, Jacob Rosenblum Rubens, William Edward Salomon, Zi Jun Wang
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240035049
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: July 19, 2023
    Publication date: February 1, 2024
    Inventors: Anne Helen Bothmer, Cecilia Giovanna Silvia Cotta-Ramusino, William Edward Salomon, Jacob Rosenblum Rubens, Robert James Citorik, Zi Jun Wang, Kyusik Kim, Randi Michelle Kotlar, Ananya Ray, Robert Charles Altshuler, Sandeep Kumar, Nathaniel Roquet, Barrett Ethan Steinberg
  • COMPOSITIONS FOR FACILITATING MEMBRANE FUSION AND USES THEREOF
    Publication number: 20240033227
    Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can fuse to the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.
    Type: Application
    Filed: January 13, 2023
    Publication date: February 1, 2024
    Inventors: Geoffrey A. von Maltzahn, John Miles Milwid, Michael Travis Mee, Jacob Rosenblum Rubens, Nathan Wilson Stebbins, Molly Krisann Gibson, Neal Francis Gordon, Bo Zhang, Kyle Marvin Trudeau, Brigham Jay Hartley, Tamar Rose Putiri, Kiana Mahdaviani, Matthew Milnes Dobbin
  • Glycan therapeutic compositions and related methods thereof
    Patent number: 11883422
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said glycan therapeutics, e.g. in cancer therapy.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: January 30, 2024
    Assignee: DSM Nutritional Products, LLC
    Inventors: Geoffrey A. von Maltzahn, Yvonne J. Yamanaka, Jared Silverman, John Miles Milwid, Jacob Rosenblum Rubens, John M. Geremia
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20240018551
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 2, 2022
    Publication date: January 18, 2024
    Inventors: Stephen CLEAVER, Barrett Ethan STEINBERG, Jacob Rosenblum RUBENS, Robert James CITORIK, William Edward SALOMON, Zi Jun WANG
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230348939
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: November 22, 2022
    Publication date: November 2, 2023
    Inventors: Anne Helen BOTHMER, Cecilia Giovanna Silvia COTTA-RAMUSINO, William Edward SALOMON, Jacob Rosenblum RUBENS, Robert James CITORIK, Zi Jun WANG, Kyusik KIM, Randi Michelle KOTLAR, Ananya RAY, Robert Charles ALTSHULER, Sandeep KUMAR, Nathaniel ROQUET, Barrett Ethan STEINBERG
  • TEMPLATE GUIDE RNA MOLECULES
    Publication number: 20230332184
    Abstract: The disclosure is directed, in part, to improved systems and nucleic acids for modifying target DNA.
    Type: Application
    Filed: December 5, 2022
    Publication date: October 19, 2023
    Inventors: Jacob Rosenblum RUBENS, Robert James CITORIK, Anne Helen BOTHMER, Aamir MIR, John Frederick BRIONES, William Edward SALOMON
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230272430
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 1, 2022
    Publication date: August 31, 2023
    Inventors: Anne Helen BOTHMER, Cecilia Giovanna Silvia COTTA-RAMUSINO, William Edward SALOMON, Jacob Rosenblum RUBENS, Robert James CITORIK, Zi Jun WANG, Kyusik KIM, Randi Michelle KOTLAR, Ananya RAY, Robert Charles ALTSHULER, Sandeep KUMAR, Nathaniel ROQUET, Barrett Ethan STEINBERG
  • DNA COMPOSITIONS AND RELATED METHODS
    Publication number: 20230255999
    Abstract: The disclosure provides, for example, single stranded, covalently closed DNA that does not form a double stranded structure longer than 100 base pairs. The ssDNA may encode an effector sequence, for instance a therapeutic protein. The ssDNA may comprise a nuclear targeting sequence (NTS). In some embodiments, the ssDNA shows decreased activation of the innate immune system compared to an otherwise similar dsDNA.
    Type: Application
    Filed: November 11, 2022
    Publication date: August 17, 2023
    Inventors: Alexandra Rachael Sneider, Jacob Rosenblum Rubens, Narahari Subbanna Pujar, Molly Krisann Gibson, Benjamin Andrew Portney, Geoffrey A. Von Maltzahn, Camilo Ayala Breton
  • METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230242899
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: September 1, 2022
    Publication date: August 3, 2023
    Inventors: Barrett Ethan STEINBERG, Anne Helen BOTHMER, William Edward SALOMON, Inna SHCHERBAKOVA, Cecilia Giovanna Silvia COTTA-RAMUSINO, Jacob Rosenblum RUBENS, Robert James CITORIK, Zi Jun WANG
  • HOST DEFENSE SUPPRESSING METHODS AND COMPOSITIONS FOR MODULATING A GENOME
    Publication number: 20230235358
    Abstract: The disclosure provides, e.g., compositions and methods for modulating a host response to a Gene Writer system. In some embodiments, modulation of the host response results in increased integration of a heterologous nucleic acid sequence of interest into a target genome. In some embodiments, modulation of the host response results in an increased stability, e.g., maintenance of an insertion or expression thereof. In some embodiments, modulation of the host response results in decreased cytotoxicity.
    Type: Application
    Filed: August 31, 2022
    Publication date: July 27, 2023
    Inventors: Robert James CITORIK, Jacob Rosenblum RUBENS, Cecilia Giovanna Silvia COTTA-RAMUSINO, William Edward SALOMON, Zi Jun WANG
  • BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF
    Publication number: 20230167450
    Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid and a second domain that specifically binds to a target protein, and uses thereof.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 1, 2023
    Applicant: Flagship Pioneering, Inc.
    Inventors: Nathan Wilson STEBBINS, Benjamin Andrew PORTNEY, Eric Bruno VALEUR, Jacob Rosenblum RUBENS, Kaveh DANESHVAR, Alexandra Rachael SNEIDER, Mitchell GUTTMAN
  • BIFUNCTIONAL MOLECULES AND METHODS OF USING THEREOF
    Publication number: 20230158156
    Abstract: The present disclosure relates generally to compositions of synthetic bifunctional molecules comprising a first domain that specifically binds to a target ribonucleic acid and a second domain that specifically binds to a target polypeptide, and uses thereof.
    Type: Application
    Filed: April 21, 2021
    Publication date: May 25, 2023
    Applicant: Flagship Pioneering, Inc.
    Inventors: Nathan Wilson STEBBINS, Benjamin Andrew PORTNEY, Eric Bruno VALEUR, Jacob Rosenblum RUBENS, Kaveh DANESHVAR, Alexandra Rachael SNEIDER
  • RECOMBINASE COMPOSITIONS AND METHODS OF USE
    Publication number: 20230131847
    Abstract: Methods and compositions for modulating a target genome are disclosed.
    Type: Application
    Filed: May 20, 2022
    Publication date: April 27, 2023
    Inventors: Jacob Rosenblum RUBENS, Robert James CITORIK, Stephen Hoyt CLEAVER, Cecilia Giovanna Silvia COTTA-RAMUSINO, Yanfang FU
  • GLYCAN COMPOSITIONS AND METHODS OF USE
    Publication number: 20230123695
    Abstract: Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for modulating exogenous substances, enzyme activities, and drug activities.
    Type: Application
    Filed: October 20, 2022
    Publication date: April 20, 2023
    Inventors: Geoffrey A. von Maltzahn, Jacob Rosenblum Rubens