Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Abstract: Therapeutic chondrisome compositions and related methods are described.

Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.

Abstract: Aspects of the present disclosure relate to genetically engineered organisms useful for the diagnosis and treatment of inflammatory bowel disease.

Abstract: Aspects of the present disclosure relate to analog signal processing circuits and methods for cellular computation.

Abstract: Aspects of the present disclosure are directed to biosensing circuits that correct crosstalk.

Abstract: Therapeutic chondrisome compositions and related methods are described.

Abstract: Provided herein are molecular analog gene circuits that exploit positive and negative feedback to implement logarithmically linear sensing, addition, subtraction, and scaling thus enabling multiplicative, ratiometric, and power-law computations. The circuits exhibit Weber's Law behavior as in natural biological systems, operate over a wide dynamic range of up to four orders of magnitude, and can be architected to have tunable transfer functions. The molecular circuits described herein can be composed together to implement higher-order functions that are well-described by both intricate biochemical models and by simple mathematical functions. The molecular circuits described herein enable logarithmically linear analog computation within in-vitro and in-vivo systems with a broad class of molecules, all of which obey the Boltzmann exponential equations of thermodynamics that govern molecular association, attenuation, transformation, and degradation.