Patents by Inventor Jacques Dubois

Jacques Dubois has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9669007
    Abstract: The invention relates to a process for producing an aqueous gel comprising hyaluronic acid, vitamin C, and a stabilizing agent selected from the metabisulfites. According to the invention, such a process comprises the steps of a) preparing a mixture comprising crosslinked or non-crosslinked hyaluronic acid and/or a salt thereof with a molar mass of between 1000 Da and 10 MDa, from 0.1 to 20.0% by weight of vitamin C in its acid form, or its equivalent in ascorbate derived from a vitamin C salt, from 0.01 to 1.00% by weight of a stabilizing agent selected from the metabisulfites, and an aqueous solution added so that the hyaluronic acid content is between 0.01 and 100 mg/ml, so as to form a hydrogel, and b) degassing the mixture before the hydrogel being formed is completely swollen.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: June 6, 2017
    Assignee: Auriga International
    Inventors: Alfred Marchal, Jerome Cabou, Damien Lacroix, Jacques Dubois
  • Patent number: 9575309
    Abstract: The present invention provides a reflective telescopic system, to control the generation of filamentation of ultrashort and intense laser pulses that includes: a flat mirror, an adaptive reflective mirror, a dichroic convex mirror, an off-axis parabolic mirror, and a first laser source. The convex mirror and the adaptive reflective mirror are mounted on an independent breadboard and set on a translation stage. The propagation axis of the laser beam reflected by the mirror should correspond to the off-axis of the parabolic mirror. The parabolic mirror reflects the beam at a specific angle. Finally, the propagation axis between the dichroic convex mirror and the off-axis parabolic mirror, the propagation axis between the flat mirror and the adaptive reflective mirror, and the axis of the translation stage should be substantially parallel to each other. The present invention also contemplates the boresighting of a weak laser beam from a second laser source.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: February 21, 2017
    Assignee: HER MAJESTY THE QUEEN IN RIGHT OF CANADA, AS REPRESENTED BY THE MINISTER OF NATIONAL DEFENCE
    Inventors: Francis Théberge, Jacques Dubois, Marc Châteauneuf
  • Patent number: 9484702
    Abstract: A method comprising using a pulse shaper in the spectral domain to generate multiple-color pulses directly at the output of the laser amplifier. The delay can thus be controlled directly in the spectral domain and there is no need for an optical delay line. The method allows reducing the number of optical components and insures insensitivity to alignment, vibrations and turbulence on long distance propagation and filamentation, particularly in air. The method allows programmable and tunable interaction, since the pulse shaper is able to control the laser spectral amplitude and phase.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: November 1, 2016
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stéphane Payeur, Philippe Lassonde, Jean-Claude Kieffer, Francis Théberge, Marc Chàteauneuf, Jacques Dubois
  • Publication number: 20160106707
    Abstract: The invention relates to a process for producing an aqueous gel comprising hyaluronic acid, vitamin C, and a stabilizing agent selected from the metabisulfites. According to the invention, such a process comprises the steps of a) preparing a mixture comprising crosslinked or non-crosslinked hyaluronic acid and/or a salt thereof with a molar mass of between 1000 Da and 10 MDa, from 0.1 to 20.0% by weight of vitamin C in its acid form, or its equivalent in ascorbate derived from a vitamin C salt, from 0.01 to 1.00% by weight of a stabilizing agent selected from the metabisulfites, and an aqueous solution added so that the hyaluronic acid content is between 0.01 and 100 mg/ml, so as to form a hydrogel, and b) degassing the mixture before the hydrogel being formed is completely swollen.
    Type: Application
    Filed: April 23, 2014
    Publication date: April 21, 2016
    Inventors: Alfred MARCHAL, Jerome CABOU, Damien LACROIX, Jacques DUBOIS
  • Patent number: 9254331
    Abstract: A stable galenic composition of a compound of general formula (I) wherein R1 and R2 both represent independently of each other an alkyl, aryl, arylalkyl group, optionally substituted with one or more linear or branched groups, optionally bearing one or more heteroatoms, comprising said compound of formula I in an amount ranging from 0.01 to 15% by weight based on the total weight of the final composition; at least one anhydrous ester, the main chain and/or optionally the branched chains of which are free from free and/or reactive groups or functions, in an amount ranging from 0.1 to 99.9% by weight based on the total weight of the cosmetically and pharmaceutically acceptable composition; and optionally a cosmetically and pharmaceutically acceptable excipient for completing the 100% of the total weight of the composition.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: February 9, 2016
    Assignee: AURIGA INTERNATIONAL
    Inventors: Jacques Dubois, Alfred Marchal, Damien Lacroix, Jérôme Cabou
  • Publication number: 20160025960
    Abstract: The present invention provides a reflective telescopic system, to control the generation of filamentation of ultrashort and intense laser pulses that includes: a flat mirror, an adaptive reflective mirror, a dichroic convex mirror, an off-axis parabolic mirror, and a first laser source. The convex mirror and the adaptive reflective mirror are mounted on an independent breadboard and set on a translation stage. The propagation axis of the laser beam reflected by the mirror should correspond to the off-axis of the parabolic mirror. The parabolic mirror reflects the beam at a specific angle. Finally, the propagation axis between the dichroic convex mirror and the off-axis parabolic mirror, the propagation axis between the flat mirror and the adaptive reflective mirror, and the axis of the translation stage should be substantially parallel to each other. The present invention also contemplates the boresighting of a weak laser beam from a second laser source.
    Type: Application
    Filed: September 10, 2012
    Publication date: January 28, 2016
    Inventors: Francis THEBERGE, Jacques DUBOIS, Marc CHATEAUNEUF
  • Publication number: 20130143963
    Abstract: A stable galenic composition of a compound of general formula (I) wherein R1 and R2 both represent independently of each other an alkyl, aryl, arylalkyl group, optionally substituted with one or more linear or branched groups, optionally bearing one or more heteroatoms, comprising said compound of formula I in an amount ranging from 0.01 to 15% by weight based on the total weight of the final composition; at least one anhydrous ester, the main chain and/or optionally the branched chains of which are free from free and/or reactive groups or functions, in an amount ranging from 0.1 to 99.9% by weight based on the total weight of the cosmetically and pharmaceutically acceptable composition; and optionally a cosmetically and pharmaceutically acceptable excipient for completing the 100% of the total weight of the composition.
    Type: Application
    Filed: July 19, 2011
    Publication date: June 6, 2013
    Applicant: Auriga International
    Inventors: Jacques Dubois, Alfred Marchal, Damien Lacroix, Jérôme Cabou
  • Publication number: 20130142739
    Abstract: A method for synthesizing an isothiocyanate of general formula (I) SCN—R1—R4—R2??(I) wherein R1 and R2 represent independently of each other an alkyl-aryl or aryl group, R4 represents a carbonyl, sulfinyl, sulfonyl group or a sulfide group and of its derivatives comprising a step for reacting an alkylalkylamine having the general formula (II) NH2—R1—R4—R2??(II) wherein R1 and R2 represent independently of each other an alkyl, aryl or alkylaryl group, R4 represents a carbonyl, sulfinyl, sulfonyl or sulfide group, in the presence of carbon sulfide and of di-tert-butyl dicarbonate with formation of the corresponding aforesaid isothiocyanate, compounds obtained by this method as well as their uses.
    Type: Application
    Filed: July 20, 2011
    Publication date: June 6, 2013
    Applicant: Auriga International
    Inventors: Jacques Dubois, Alfred Marchal, Damien Lacroix, Jérôme Cabou
  • Publication number: 20130053347
    Abstract: The present invention relates to the biology and mechanism of action of the naturally occurring compound Narciclasine, especially as an anti-cancer agent for brain tumors. The invention provides new insights on the target molecule of Amaryllidaceae isocarbostyril derivatives as for example Narciclasine and provides new prodrugs of these Amaryllidceae isocabostyril constituents for treating cancer, specifically cancers or tumors located in the brain.
    Type: Application
    Filed: May 3, 2010
    Publication date: February 28, 2013
    Applicant: Universite Libre de Bruxelles
    Inventors: Veronique Mathieu, Gwendoline Van Goietsenoven, Jacques Dubois, Florence Lefranc-Kiss, Laurent Ingrassia, Robert Kiss
  • Publication number: 20120243564
    Abstract: A method comprising using a pulse shaper in the spectral domain to generate multiple-color pulses directly at the output of the laser amplifier. The delay can thus be controlled directly in the spectral domain and there is no need for an optical delay line. The method allows reducing the number of optical components and insures insensitivity to alignment, vibrations and turbulence on long distance propagation and filamentation, particularly in air. The method allows programmable and tunable interaction, since the pulse shaper is able to control the laser spectral amplitude and phase.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 27, 2012
    Inventors: STÉPHANE PAYEUR, PHILIPPE LASSONDE, JEAN-CLAUDE KIEFFER, FRANCIS THÉBERGE, MARC CHÂTEAUNEUF, JACQUES DUBOIS
  • Publication number: 20120141618
    Abstract: This invention concerns a process for preparing integral olive liquor consisting of the following stages: a) selecting the olives according to their maturity, b) grinding and mixing the olives selected in the form of drupes, c) pressing the paste obtained in the previous phase, d) separating the liquor obtained in order to separate it from the solid parts, e) collecting the integral olive liquor in the form of a stable, gelified emulsion. A composition based on integral olive liquor obtained according to the process subject of the invention, comprising a mixture of the oily phase and the aqueous phase of the olive is also claimed in addition to its use in the field of cosmetics and/or nutrition.
    Type: Application
    Filed: August 10, 2010
    Publication date: June 7, 2012
    Inventors: Raphaël Colicci, Jacques Dubois, Jean-Louis Lafaurie
  • Publication number: 20110280940
    Abstract: The invention relates to the medical field, more precisely in the field of anti-cancer treatment and treatment of Alzheimer's disease, Parkinson's disease or Pick's disease or for ameliorating symptoms of Down syndrome, providing newly synthesised multi-vanilloyl derivative compounds and their use in the treatment of said disorders.
    Type: Application
    Filed: October 13, 2009
    Publication date: November 17, 2011
    Inventors: Robert Kiss, Jacques Dubois, Jean Neve, Delphine Lamoral-Theys, Francois Dufrasne, Laurent Pottier
  • Publication number: 20100074851
    Abstract: A cosmetic or pharmaceutical composition includes particles of hyaluronic acid having a molecular weight between 20000 Da and 3000000 Da, combined with a polyamine.
    Type: Application
    Filed: August 1, 2007
    Publication date: March 25, 2010
    Applicant: Auriga International S.A.
    Inventors: Jacques Dubois, Alfred Marchal
  • Patent number: 7414568
    Abstract: A laser warning receiver (LWR) to detect a very low power laser beam for a laser beam rider and provide a high angular resolution in determining the angle-of-arrival of that beam. An aperture having a fixed field-of-view (FOV) is located in a detection channel followed by a narrow-band filter and a detector whose output is applied to a pulse analyzer circuit. A localization channel with the same FOV has a similar narrow-band filter and a lens to focus light from that FOV onto a detector through a N×M element LCD matrix, an output of that detector being applied to the pulse analyzer circuit whose output is applied to a LCD pattern selector connected to the matrix which controls elements in the matrix to provide a transparent window of variable size and position. The size and position of that window allows a laser beam to reach the detector, the window being iterative reduced in size when a beam is detected to provide the location of its source.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: August 19, 2008
    Assignee: Her Majesty the Queen in right of Canada, as represented by the Minister of National Defence of Her Majesty's Canadian Government
    Inventors: Jean Fortin, Jacques Dubois
  • Patent number: 7175130
    Abstract: A guidance system for a missile with a laser beam source located at a distance from the missile generating a modulated laser beam that is directed towards the missile. A group of backward looking sensors on the body of the missile detect any radiation scattered from the laser beam along with a group of forward looking sensors located on the missile. Both groups look at an angle to the missile's longitudinal axis. Signals from the sensors are applied to processing electronics in the missile that determine the phase shift in signals derived from when a backward looking sensor detects scattered radiation from a laser beam and a forward looking sensor detects scattered radiation from that beam. The processing electronics can then accurately determine the distance between the missile and the beam from the phase shift and correct the missile's trajectory to maintain its position with respect to the beam.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: February 13, 2007
    Assignee: Her Majesty the Queen in right of Canada, as represented by the Minister of National Defence of Her Majesty's Canadian Government
    Inventors: Jacques Dubois, Jean Fortin, Pierre Mathieu
  • Patent number: 7150428
    Abstract: A guidance system for a missile utilitizes a laser beam source at a missile launch pad to generate a laser beam that is directed towards a target. A sensor on the body of a spinning missile detects radiation scattered from the laser beam, the sensor looking sideways and backward at an angle to the missile's longitudinal axis. Signals generated by that sensor are applied to a missile's guidance system's processing electronics that then determines the distance from the missile to the beam from the width of the signal generated by the sensor due to detecting scattered radiation from that laser beam. Once the distance between the missile and the beam is determined, the missile's guidance system corrects the missile's trajectory to maintain its position at a predetermined distance from the beam.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: December 19, 2006
    Assignee: Her Majesty the Queen in right of Canada, as represented by the Minister of National Defence
    Inventors: Jacques Dubois, Jean Fortin
  • Publication number: 20060108499
    Abstract: A laser warning receiver (LWR) to detect a very low power laser beam for a laser beam rider and provide a high angular resolution in determining the angle-of-arrival of that beam. An aperture having a fixed field-of-view (FOV) is located in a detection channel followed by a narrow-band filter and a detector whose output is applied to a pulse analyzer circuit. A localization channel with the same FOV has a similar narrow-band filter and a lens to focus light from that FOV onto a detector through a N×M element LCD matrix, an output of that detector being applied to the pulse analyzer circuit whose output is applied to a LCD pattern selector connected to the matrix which controls elements in the matrix to provide a transparent window of variable size and position. The size and position of that window allows a laser beam to reach the detector, the window being iterative reduced in size when a beam is detected to provide the location of its source.
    Type: Application
    Filed: March 25, 2003
    Publication date: May 25, 2006
    Inventors: Jean Fortin, Jacques Dubois
  • Publication number: 20060049299
    Abstract: A guidance system for a missile utilitizes a laser beam source at a missile launch pad to generate a laser beam that is directed towards a target. A sensor on the body of a spinning missile detects radiation scattered from the laser beam, the sensor looking sideways and backward at an angle to the missile's longitudinal axis. Signals generated by that sensor are applied to a missile's guidance system's processing electronics that then determines the distance from the missile to the beam from the width of the signal generated by the sensor due to detecting scattered radiation from that laser beam. Once the distance between the missile and the beam is determined, the missile's guidance system corrects the missile's trajectory to maintain its position at a predetermined distance from the beam.
    Type: Application
    Filed: September 3, 2004
    Publication date: March 9, 2006
    Inventors: Jacques Dubois, Jean Fortin
  • Publication number: 20060049300
    Abstract: A guidance system for a missile with a laser beam source located at a distance from the missile generating a modulated laser beam that is directed towards the missile. A group of backward looking sensors on the body of the missile detect any radiation scattered from the laser beam along with a group of forward looking sensors located on the missile. Both groups look at an angle to the missile's longitudinal axis. Signals from the sensors are applied to processing electronics in the missile that determine the phase shift in signals derived from when a backward looking sensor detects scattered radiation from a laser beam and a forward looking sensor detects scattered radiation from that beam. The processing electronics can then accurately determine the distance between the missile and the beam from the phase shift and correct the missile's trajectory to maintain its position with respect to the beam.
    Type: Application
    Filed: September 3, 2004
    Publication date: March 9, 2006
    Inventors: Jacques Dubois, Jean Fortin, Pierre Mathieu
  • Publication number: 20050288300
    Abstract: This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against maxillary sinus pathogenic pathogenic bacteria.
    Type: Application
    Filed: August 8, 2005
    Publication date: December 29, 2005
    Inventors: Jacques Dubois, Claude St-Pierre