Abstract: The invention relates to a process for producing an aqueous gel comprising hyaluronic acid, vitamin C, and a stabilizing agent selected from the metabisulfites. According to the invention, such a process comprises the steps of a) preparing a mixture comprising crosslinked or non-crosslinked hyaluronic acid and/or a salt thereof with a molar mass of between 1000 Da and 10 MDa, from 0.1 to 20.0% by weight of vitamin C in its acid form, or its equivalent in ascorbate derived from a vitamin C salt, from 0.01 to 1.00% by weight of a stabilizing agent selected from the metabisulfites, and an aqueous solution added so that the hyaluronic acid content is between 0.01 and 100 mg/ml, so as to form a hydrogel, and b) degassing the mixture before the hydrogel being formed is completely swollen.

Abstract: The present invention provides a reflective telescopic system, to control the generation of filamentation of ultrashort and intense laser pulses that includes: a flat mirror, an adaptive reflective mirror, a dichroic convex mirror, an off-axis parabolic mirror, and a first laser source. The convex mirror and the adaptive reflective mirror are mounted on an independent breadboard and set on a translation stage. The propagation axis of the laser beam reflected by the mirror should correspond to the off-axis of the parabolic mirror. The parabolic mirror reflects the beam at a specific angle. Finally, the propagation axis between the dichroic convex mirror and the off-axis parabolic mirror, the propagation axis between the flat mirror and the adaptive reflective mirror, and the axis of the translation stage should be substantially parallel to each other. The present invention also contemplates the boresighting of a weak laser beam from a second laser source.

Abstract: A method comprising using a pulse shaper in the spectral domain to generate multiple-color pulses directly at the output of the laser amplifier. The delay can thus be controlled directly in the spectral domain and there is no need for an optical delay line. The method allows reducing the number of optical components and insures insensitivity to alignment, vibrations and turbulence on long distance propagation and filamentation, particularly in air. The method allows programmable and tunable interaction, since the pulse shaper is able to control the laser spectral amplitude and phase.

Abstract: The invention relates to a process for producing an aqueous gel comprising hyaluronic acid, vitamin C, and a stabilizing agent selected from the metabisulfites. According to the invention, such a process comprises the steps of a) preparing a mixture comprising crosslinked or non-crosslinked hyaluronic acid and/or a salt thereof with a molar mass of between 1000 Da and 10 MDa, from 0.1 to 20.0% by weight of vitamin C in its acid form, or its equivalent in ascorbate derived from a vitamin C salt, from 0.01 to 1.00% by weight of a stabilizing agent selected from the metabisulfites, and an aqueous solution added so that the hyaluronic acid content is between 0.01 and 100 mg/ml, so as to form a hydrogel, and b) degassing the mixture before the hydrogel being formed is completely swollen.

Abstract: A stable galenic composition of a compound of general formula (I) wherein R1 and R2 both represent independently of each other an alkyl, aryl, arylalkyl group, optionally substituted with one or more linear or branched groups, optionally bearing one or more heteroatoms, comprising said compound of formula I in an amount ranging from 0.01 to 15% by weight based on the total weight of the final composition; at least one anhydrous ester, the main chain and/or optionally the branched chains of which are free from free and/or reactive groups or functions, in an amount ranging from 0.1 to 99.9% by weight based on the total weight of the cosmetically and pharmaceutically acceptable composition; and optionally a cosmetically and pharmaceutically acceptable excipient for completing the 100% of the total weight of the composition.

Abstract: The present invention provides a reflective telescopic system, to control the generation of filamentation of ultrashort and intense laser pulses that includes: a flat mirror, an adaptive reflective mirror, a dichroic convex mirror, an off-axis parabolic mirror, and a first laser source. The convex mirror and the adaptive reflective mirror are mounted on an independent breadboard and set on a translation stage. The propagation axis of the laser beam reflected by the mirror should correspond to the off-axis of the parabolic mirror. The parabolic mirror reflects the beam at a specific angle. Finally, the propagation axis between the dichroic convex mirror and the off-axis parabolic mirror, the propagation axis between the flat mirror and the adaptive reflective mirror, and the axis of the translation stage should be substantially parallel to each other. The present invention also contemplates the boresighting of a weak laser beam from a second laser source.

Abstract: A stable galenic composition of a compound of general formula (I) wherein R1 and R2 both represent independently of each other an alkyl, aryl, arylalkyl group, optionally substituted with one or more linear or branched groups, optionally bearing one or more heteroatoms, comprising said compound of formula I in an amount ranging from 0.01 to 15% by weight based on the total weight of the final composition; at least one anhydrous ester, the main chain and/or optionally the branched chains of which are free from free and/or reactive groups or functions, in an amount ranging from 0.1 to 99.9% by weight based on the total weight of the cosmetically and pharmaceutically acceptable composition; and optionally a cosmetically and pharmaceutically acceptable excipient for completing the 100% of the total weight of the composition.

Abstract: A method for synthesizing an isothiocyanate of general formula (I) SCN—R1—R4—R2??(I) wherein R1 and R2 represent independently of each other an alkyl-aryl or aryl group, R4 represents a carbonyl, sulfinyl, sulfonyl group or a sulfide group and of its derivatives comprising a step for reacting an alkylalkylamine having the general formula (II) NH2—R1—R4—R2??(II) wherein R1 and R2 represent independently of each other an alkyl, aryl or alkylaryl group, R4 represents a carbonyl, sulfinyl, sulfonyl or sulfide group, in the presence of carbon sulfide and of di-tert-butyl dicarbonate with formation of the corresponding aforesaid isothiocyanate, compounds obtained by this method as well as their uses.

Abstract: The present invention relates to the biology and mechanism of action of the naturally occurring compound Narciclasine, especially as an anti-cancer agent for brain tumors. The invention provides new insights on the target molecule of Amaryllidaceae isocarbostyril derivatives as for example Narciclasine and provides new prodrugs of these Amaryllidceae isocabostyril constituents for treating cancer, specifically cancers or tumors located in the brain.

Abstract: A method comprising using a pulse shaper in the spectral domain to generate multiple-color pulses directly at the output of the laser amplifier. The delay can thus be controlled directly in the spectral domain and there is no need for an optical delay line. The method allows reducing the number of optical components and insures insensitivity to alignment, vibrations and turbulence on long distance propagation and filamentation, particularly in air. The method allows programmable and tunable interaction, since the pulse shaper is able to control the laser spectral amplitude and phase.

Abstract: This invention concerns a process for preparing integral olive liquor consisting of the following stages: a) selecting the olives according to their maturity, b) grinding and mixing the olives selected in the form of drupes, c) pressing the paste obtained in the previous phase, d) separating the liquor obtained in order to separate it from the solid parts, e) collecting the integral olive liquor in the form of a stable, gelified emulsion. A composition based on integral olive liquor obtained according to the process subject of the invention, comprising a mixture of the oily phase and the aqueous phase of the olive is also claimed in addition to its use in the field of cosmetics and/or nutrition.

Abstract: The invention relates to the medical field, more precisely in the field of anti-cancer treatment and treatment of Alzheimer's disease, Parkinson's disease or Pick's disease or for ameliorating symptoms of Down syndrome, providing newly synthesised multi-vanilloyl derivative compounds and their use in the treatment of said disorders.

Abstract: A cosmetic or pharmaceutical composition includes particles of hyaluronic acid having a molecular weight between 20000 Da and 3000000 Da, combined with a polyamine.

Abstract: A laser warning receiver (LWR) to detect a very low power laser beam for a laser beam rider and provide a high angular resolution in determining the angle-of-arrival of that beam. An aperture having a fixed field-of-view (FOV) is located in a detection channel followed by a narrow-band filter and a detector whose output is applied to a pulse analyzer circuit. A localization channel with the same FOV has a similar narrow-band filter and a lens to focus light from that FOV onto a detector through a N×M element LCD matrix, an output of that detector being applied to the pulse analyzer circuit whose output is applied to a LCD pattern selector connected to the matrix which controls elements in the matrix to provide a transparent window of variable size and position. The size and position of that window allows a laser beam to reach the detector, the window being iterative reduced in size when a beam is detected to provide the location of its source.

Abstract: A guidance system for a missile with a laser beam source located at a distance from the missile generating a modulated laser beam that is directed towards the missile. A group of backward looking sensors on the body of the missile detect any radiation scattered from the laser beam along with a group of forward looking sensors located on the missile. Both groups look at an angle to the missile's longitudinal axis. Signals from the sensors are applied to processing electronics in the missile that determine the phase shift in signals derived from when a backward looking sensor detects scattered radiation from a laser beam and a forward looking sensor detects scattered radiation from that beam. The processing electronics can then accurately determine the distance between the missile and the beam from the phase shift and correct the missile's trajectory to maintain its position with respect to the beam.

Abstract: A guidance system for a missile utilitizes a laser beam source at a missile launch pad to generate a laser beam that is directed towards a target. A sensor on the body of a spinning missile detects radiation scattered from the laser beam, the sensor looking sideways and backward at an angle to the missile's longitudinal axis. Signals generated by that sensor are applied to a missile's guidance system's processing electronics that then determines the distance from the missile to the beam from the width of the signal generated by the sensor due to detecting scattered radiation from that laser beam. Once the distance between the missile and the beam is determined, the missile's guidance system corrects the missile's trajectory to maintain its position at a predetermined distance from the beam.

Abstract: A laser warning receiver (LWR) to detect a very low power laser beam for a laser beam rider and provide a high angular resolution in determining the angle-of-arrival of that beam. An aperture having a fixed field-of-view (FOV) is located in a detection channel followed by a narrow-band filter and a detector whose output is applied to a pulse analyzer circuit. A localization channel with the same FOV has a similar narrow-band filter and a lens to focus light from that FOV onto a detector through a N×M element LCD matrix, an output of that detector being applied to the pulse analyzer circuit whose output is applied to a LCD pattern selector connected to the matrix which controls elements in the matrix to provide a transparent window of variable size and position. The size and position of that window allows a laser beam to reach the detector, the window being iterative reduced in size when a beam is detected to provide the location of its source.

Abstract: A guidance system for a missile with a laser beam source located at a distance from the missile generating a modulated laser beam that is directed towards the missile. A group of backward looking sensors on the body of the missile detect any radiation scattered from the laser beam along with a group of forward looking sensors located on the missile. Both groups look at an angle to the missile's longitudinal axis. Signals from the sensors are applied to processing electronics in the missile that determine the phase shift in signals derived from when a backward looking sensor detects scattered radiation from a laser beam and a forward looking sensor detects scattered radiation from that beam. The processing electronics can then accurately determine the distance between the missile and the beam from the phase shift and correct the missile's trajectory to maintain its position with respect to the beam.

Abstract: A guidance system for a missile utilitizes a laser beam source at a missile launch pad to generate a laser beam that is directed towards a target. A sensor on the body of a spinning missile detects radiation scattered from the laser beam, the sensor looking sideways and backward at an angle to the missile's longitudinal axis. Signals generated by that sensor are applied to a missile's guidance system's processing electronics that then determines the distance from the missile to the beam from the width of the signal generated by the sensor due to detecting scattered radiation from that laser beam. Once the distance between the missile and the beam is determined, the missile's guidance system corrects the missile's trajectory to maintain its position at a predetermined distance from the beam.

Abstract: This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against maxillary sinus pathogenic pathogenic bacteria.