Patents by Inventor Jacques Dumas

Jacques Dumas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
    Patent number: 7235576
    Abstract: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: June 26, 2007
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Bernd Riedl, Jacques Dumas, Uday Khire, Timothy B. Lowinger, William J. Scott, Roger A. Smith, Jill E. Wood, Mary-Katherine Monahan, Reina Natero, Joel Renick, Robert N. Sibley
  • Diaryl ureas with kinase inhibiting activity
    Publication number: 20070020704
    Abstract: The present invention provides methods of using aryl ureas to treat diseases and conditions associated with signal transduction pathways comprising at least one of raf, VEGFR, PDGFR, p38 and/or FLT-3. The present invention also provides compositions and methods for identifying conditions and diseases which can be modulated with compounds of the present invention. These methods facilitate the selection of subjects who can be efficiently treated with compounds of the present invention. Additionally, the invention provides methods for monitoring subjects who have been administered a compound of the present invention.
    Type: Application
    Filed: May 19, 2004
    Publication date: January 25, 2007
    Inventors: Scott Wilhelm, Jacques Dumas, Gaetan Ladouceur, Mark Lynch, William Scott
  • Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders
    Publication number: 20060293322
    Abstract: The present invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
    Type: Application
    Filed: July 23, 2004
    Publication date: December 28, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan Ladouceur, Catherine Brennan, Brent Chandler, Julie Dizon, Karl Miranda, Dongping Fan, Qingming Zhu, Sharad Verma, Jacques Dumas
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
    Publication number: 20060287387
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 21, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott Wilhelm, Qian Zhao
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
    Patent number: 7144885
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: December 5, 2006
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin D. Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott M. Wilhelm, Qian Zhao
  • Method of treating cancer with quinolone carboxylic acid derivatives
    Publication number: 20060142295
    Abstract: This invention relates to a method of treating a hyper-proliferative disorder comprising the administration of an effective amount of a compound of Formula (I) to a patient in need thereof.
    Type: Application
    Filed: March 5, 2004
    Publication date: June 29, 2006
    Inventors: Jacques Dumas, Uday Khire, Shirley Lasch, Dhanapalan Nagarathnam, William Scott
  • Pharmaceutical compositions for the treatment of hyper-proliferative disorders
    Publication number: 20060058358
    Abstract: This invention relates to novel pharmaceutical compositions comprising a solid dispersion of the compound of Formula I below, to processes for preparing these novel pharmaceutical compositions and to their use for treating hyper-proliferative disorders, such as cancer, either as a sole agent or in combination with other therapies.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 16, 2006
    Inventors: Jacques Dumas, Paul Ehrlich, Susanne Zuleger
  • Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
    Publication number: 20060019990
    Abstract: The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
    Type: Application
    Filed: June 22, 2005
    Publication date: January 26, 2006
    Inventors: Jacques Dumas, Bernd Riedl, Uday Khire, Robert Sibley, Holia Hatoum-Mokdad, Mary-Katherine Monahan, David Gunn, Timotthy Lowinger, William Scott, Roger Smith, Jill Wood
  • Indolyl pyrazinone derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Publication number: 20060004011
    Abstract: This invention relates to a compound of Formula I (I) and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.
    Type: Application
    Filed: November 10, 2003
    Publication date: January 5, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Gaetan Ladouceur, Brian Bear, Cheng Bi, David Brittelli, Michael Burke, Gang Chen, James Cook, Jacques Dumas, Robert Sibley, Michael Turner
  • 2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
    Publication number: 20050215594
    Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
    Type: Application
    Filed: April 28, 2005
    Publication date: September 29, 2005
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Stephen O'Connor, Gaetan Ladouceur, William Bullock, Ann-Marie Campbell, Miao Dai, Robert Dally, Jacques Dumas, Holia Hatoum-Mokdad, Uday Khire, Wendy Lee, Qingjie Liu, Derek Lowe, Steven Magnuson, Ning Qi, Tatiana Skelekhin, Quanrong Shen, Roger Smith, Ming Wang
  • Rho-kinase inhibitors
    Publication number: 20050209261
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: April 22, 2005
    Publication date: September 22, 2005
    Inventors: Dhanapalan Nagarathnam, Jacques Dumas, Holia Hatoum-Mokdad, Stephen Boyer, Hans Pluempe
  • Rho-kinase inhibitors
    Patent number: 6943172
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: September 13, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Dhanapalan Nagarathnam, Jacques Dumas, Holia Hatoum-Mokdad, Stephen Boyer, Hans Pluempe
  • Rho-kinase inhibitors
    Publication number: 20050192304
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Application
    Filed: April 18, 2005
    Publication date: September 1, 2005
    Inventors: Dhanapalan Nagarathnam, Jacques Dumas, Holia Hatoum-Mokdad, Stephen Boyer, Chunguang Wang, Hans Pluempe, Achim Feurer, Samir Bennabi
  • Rho-kinase inhibitors
    Patent number: 6924290
    Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
    Type: Grant
    Filed: January 23, 2003
    Date of Patent: August 2, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Dhanapalan Nagarathnam, Jacques Dumas, Holia Hatoum-Mokdad, Stephen Boyer, Chunguang Wang, Hans Pluempe, Achim Feurer, Samir Bennabi
  • Fused tricyclic heterocycles useful for treating hyper-proliferative disoroders
    Publication number: 20050165042
    Abstract: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: February 21, 2003
    Publication date: July 28, 2005
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Benjamin Jones, Gaetan Ladouceur, Wendy Lee, Barton Phillips, Scott Wilheim, Qian Zhao
  • 2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists
    Patent number: 6919371
    Abstract: This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
    Type: Grant
    Filed: September 17, 2003
    Date of Patent: July 19, 2005
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Stephen J. O'Connor, Gaetan H. Ladouceur, William H. Bullock, Ann-Marie Campbell, Miao Dai, Robert Dally, Jacques Dumas, Holia N. Hatoum-Mokdad, Uday Khire, Wendy Lee, Qingjie Liu, Derek B. Lowe, Steven R. Magnuson, Ning Qi, Tatiana E. Shelekhin, Quanrong Shen, Roger A. Smith, Ming Wang
  • Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders
    Publication number: 20050139814
    Abstract: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
    Type: Application
    Filed: February 21, 2003
    Publication date: June 30, 2005
    Inventors: Chengzhi Zhang, Michael Burke, Zhi Chen, Jacques Dumas, Dongping Fan, Jianmei Fan, Holia Hatoum-Mokdad, Benjamin Jones, Gaetan Ladouceur, Wendy Lee, Barton Philiips
  • Diaryl ureas for diseases mediated by PDGFR
    Publication number: 20050059703
    Abstract: The present invention provides methods for treating and/or preventing conditions and diseases in humans and other mammals that are associated with and/or mediated by signal transduction pathways comprising platelet-derived growth factor receptor (PDGFR) by administering diaryl ureas of Formula I. The present invention also provides devices and methods for treating, ameliorating, preventing, or modulating restenosis following angioplastic surgery or other invasive procedures that affect or injure the vascular system, and graft rejection following transplantation of a donor tissue into a host, where a stent or other omplantable device comprises an effective amount of diaryl ureas of Formula I.
    Type: Application
    Filed: May 19, 2004
    Publication date: March 17, 2005
    Inventors: Scott Wilhelm, Jacques Dumas, Gaetan Ladouceur, Mark Lynch, William Scott
  • Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
    Publication number: 20050038080
    Abstract: A compound of Formula (I): salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3.
    Type: Application
    Filed: July 22, 2004
    Publication date: February 17, 2005
    Inventors: Stephen Boyer, Jacques Dumas, Bernd Riedl, Scott Wilhelm
  • Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders
    Publication number: 20050038031
    Abstract: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
    Type: Application
    Filed: March 1, 2004
    Publication date: February 17, 2005
    Inventors: Jacques Dumas, Stephen Boyer, Sharad Verma, Lila Adnane, Yuanwei Chen, Wendy Lee, Barton Phillips, Roger Smith, William Scott, Jennifer Burke, Jianqing Chen, Zhi Chen, Jianmei Fan, Karl Miranda, Brian Raudenbush, Aniko Redman, Jianxing Shao, Ning Su, Gan Wang, Lin Yi, Qingming Zhu