Abstract: The invention concerns a device and a process, the device being a cleaning device utilizing a dry chemical means assisted by plasma from a reactor (10) containing an unwanted deposit on its walls and at least one other polarizable surface (12), characterized in that it comprises means (13, 14) for positively polarizing one or each of the polarizable surfaces relative to the reactor walls maintained at a reference potential.

Abstract: A compound useful for treating subjects in need of therapy involving sigma receptors or for alleviation of affects resulting from drug abuse having the general formula I in which R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle such as, for example, radicals of optionally substituted piperidines, optionally substituted piperazines, optionally substituted tetrahydropyridines, optionally substituted azepanes, tertiary amines (cyclic or acyclic), isoindoline-1,3-dione, or optionally substituted tetrahydroisoquinolones (aromatically substituted): R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.

Abstract: Compounds having the general formula II, III, or IV wherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.

Abstract: The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient.

Abstract: A compound useful for treating subjects in need of therapy involving sigma receptors or for alleviation of affects resulting from drug abuse having the general formula I in which R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle such as, for example, radicals of optionally substituted piperidines, optionally substituted piperazines, optionally substituted tetrahydropyridines, optionally substituted azepanes, tertiary amines (cyclic or acyclic), isoindoline-1,3-dione, or optionally substituted tetrahydroisoquinolones (aromatically substituted): R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.

Abstract: The invention relates to a cleaning machine (MA) comprising a vessel (VE) having a stirring member (BA) mounted therein, the stirring member carrying a load of utensils of a first type. The stirring member also carries a load of utensils of a second type. The invention also provides a method of cleaning using such a machine, containing a cleaning liquid (WA). The method has a first cleaning stage during which the level of the liquid (WA) is lower than or equal to the level of the content of the stirring member (BA). It optionally includes a second cleaning stage during which the level of the liquid (WA) is higher than the level of the content of the stirring member (BA).

Abstract: A method for preparing recombinant dimeric proteins using a nucleic acid coding for the C-terminal fragment of the C4BP protein ? chain including amino acid residues 193 to 252 or a functional variant of the fragment, wherein the fragment enables covalent bonding of the heterologous polypeptides to which it is fused. Dimeric proteins obtained by means of the method and cells for carrying out the method are also described.

Abstract: Compounds having the general formula II, III, or IV wherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR.

Abstract: The invention relates to a method of manufacturing (100) a multilayer structure on a support, the said structure comprising n elemental active layers of material, n being an integer greater than or equal to two, the method comprising at least the following steps: a step of depositing (200) a first elemental active layer of material, a step of depositing (300) an nth elemental active layer of material, characterized in that the method includes a single step of implanting ionic species (600) on the n elemental active layers of material deposited, through a resist, which is appropriate for modifying respective properties of each of the n elemental active layers in order to obtain a multilayer structure having controlled properties.

Abstract: The invention concerns a device and a process, the device being a cleaning device utilizing a dry chemical means assisted by plasma from a reactor (10) containing an unwanted deposit on its walls and at least one other polarizable surface (12), characterized in that it comprises means (13, 14) for positively polarizing one or each of the polarizable surfaces relative to the reactor walls maintained at a reference potential.

Abstract: The present invention provides a novel approach to the modulation of the immune response, directing it towards specific antigens, away from antigens against which no response is desired. The invention is based on the use of viral immune evasion proteins, such as UL49.5, which block antigen presentation to CD8+ T cells. The viral immune evasion proteins are used for: 1) the induction of tumor-specific or virus-specific immunity in cases where a conventional immune response is absent due to antigen processing defects; 2) the induction of empty MHC class I molecules at the cell surface that can be loaded with peptides of a desired specificity; 3) the inhibition of unwanted immune responses against transplanted tissues or organs, e.g. against islets of Langerhans in type 1 diabetes or allogeneic stem cells, or against self antigens in the case of autoimmunity.

Abstract: The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: The invention relates to a cleaning machine (MA) comprising a vessel (VE) having a stirring member (BA) mounted therein, the stirring member carrying a load of utensils of a first type. The stirring member also carries a load of utensils of a second type. The invention also provides a method of cleaning using such a machine, containing a cleaning liquid (WA). The method has a first cleaning stage during which the level of the liquid (WA) is lower than or equal to the level of the content of the stirring member (BA). It optionally includes a second cleaning stage during which the level of the liquid (WA) is higher than the level of the content of the stirring member (BA).

Abstract: A method for separating a metal (a) from a metal (2), preferably zirconium from hafnium, which consists in dissolving said metals in an aqueous solution wherein said metals are in a state preventing them from passing through a nanofiltration membrane; treating the aqueous medium with a ligand, for example EDTA, which is complexed with metal (1) and/or metal (2), then in passing the resulting treated medium on a filtering membrane allowing through the ligand-metal complexes, but retaining the metals not complexed with the ligand.

Abstract: The invention concerns a method for making an extreme ultraviolet microlithography transmission modulator, characterised in that it consists in obtaining adamantine amorphous carbon by a process using a plasma consisting of a mixture of acetylene and argon and maintained by the power of a microwave source; in depositing a thin adamantine amorphous carbon film on a substrate with low absorption in extreme ultraviolet whereto is applied a variable polarisation; in varying the forbidden band between 1 and 2 eV through control of the argon partial pressure and in varying the corresponding extinction coefficient so as to modulate the modulator transmission without modifying the thickness of the deposited film.

Abstract: The invention concerns a method for separating a metal (1) from a metal (2), preferably zirconium from hafnium, which consists in dissolving said metals in an aqueous solution wherein said metals are in a state preventing them from passing through a nanofiltration membrane; treating the aqueous medium with a ligand, for example EDTA, which is complexed with metal (1) and/or metal (2), then in passing the resulting treated medium on a filtering membrane allowing through the ligand-metal complexes, but retaining the metals not complexed with the ligand.

Abstract: A holster belt for frictionally fitting over a shoulder and against the chest and back of an individual, said holster belt having: an elongated elastic band having releasable hooking first and second clamp buckles at its opposite ends for attachment to opposite sides of a wearer's waist belt, a generally open holster assembly, mounted at the end portion of said elastic band proximate said first clamp buckle for supporting and retaining a box-like article against the wearer's chest, said holster assembly formed by a belt loop of the holster belt; at least one elastic loop strip being transversely mounted to an intermediate section of said belt loop to accommodate and releasably retain against accidental release said box-like article.

Abstract: In a method of administering a capital funding system, a first predetermined monetary sum, representing a principle amount of a bond, is accepted as a loan from a subscribing entity. A second predetermined monetary sum, representing a first portion of an interest payment for the first predetermined monetary sum, is periodically transferred to the subscribing entity, the second monetary sum. At least one service voucher is periodically transferred to the subscribing entity, the service voucher having a value representing a second portion of an interest payment for the first predetermined monetary sum and entitling a bearer to a predetermined quantity of a selected service.