Abstract: The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.

Abstract: The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.

Abstract: Bonito hydrolysate (e.g. katsuobushi oligopeptide (KO)) enhances the flavour of salt and may be used to replace salt in foods and beverages.

Abstract: Bonito hydrolysate (e.g. katsuobushi oligopeptide (KO)) enhances the flavour of salt and may be used to replace salt in foods and beverages.

Abstract: Bolometer cooled to a very low temperature, wherein the sensitive element has a very low thermal capacity and, for this purpose, a semiconductor crystal extended on two faces by beams made of the same material, but of smaller section, which have been metallized. These metallized beams, wherein the volume of crystal has been reduced to a minimum by their very small section, directly or indirectly provide the thermal link with the cryostat and the electrical link with the measuring circuit making it possible to eliminate all welds using bonding metal on the side of the crystal which forms part of the sensitive element. In a preferred mode of embodiment, the thermal substrate thermally linked to the crystal is a piece of monocrystalline diamond.