Abstract: The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.

Abstract: A modified chemical vapor deposition (MCVD) device for making an optical fiber preform is disclosed. The MCVD device includes a quartz tube and its junctions, a bubbler system for generating reaction gas to be supplied to the quartz tube, and a rotary connector for interfacing the bubbler system to a main shaft of the lathe supporting the quartz tube. The device isolates the quartz tube and its junctions, the bubbler system and the rotary connector from external atmosphere to keep the isolated area to be under the inert gas condition, thereby preventing moisture or hydrogen components from penetrating into the quarts tube from the external atmosphere.

Abstract: The invention relates to a series of pyrrolopyrimidinone derivatives of the formula (1): wherein R1 is H; C1-C3 alkyl optionally substituted with one or more fluoro atoms; or C3-C6 cycloalkyl; R2 is H; a halogen atom; C1-C6 alkyl optionally substituted with OH, C1-C3 alkoxy, C3-C6 cycloalkyl, or with one or more fluoro atoms; C3-C6 cycloalkyl; C2-C6 alkenyl; or C2-C6 alkynyl; R3 is H; C1-C6 alkyl optionally substituted with OH, C1-C3 alkoxy, C3-C6 cycloalkyl, or with one or more fluoro atoms; C3-C6 cycloalkyl; C2-C6 alkenyl; or C2-C6 alkynyl; R4 is C1-C6 alkyl optionally substituted with C3-C6 cycloalkyl or with one or more fluoro atoms; C2-C6 alkenyl; C2-C6 alkynyl; or C3-C6 cycloalkyl; and R5 is SO2NR6R7; NHSO2NR6R7; NHCOCONR6R7; NHSO2R8; NHCOR8; or phenyl or heterocyclyl either of which is optionally substituted with one or more fluoro atoms or C1-C3 alkyl.

Abstract: The invention relates to a series of pyrrolopyrimidinone derivatives, processes for their preparation, intermediates in their preparation, their use as therapeutic agents, and pharmaceutical compositions containing them.

Abstract: Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.

Abstract: Method for fabricating an optical fiber preform substantially without hydroxyl group in core includes forming clad layer having relatively low refractive index by depositing soot (SiO2, GeO2) to inner surface of quartz tube; and forming core layer having relatively high refractive index on clad layer, which includes (a) a base core layer forming step composed of generating soot by heating inside of quartz tube to 1000° C.-1400° C. with introducing reaction gases (SiCl4GeCl4) into quartz tube, accumulating soot on clad layer removing hydroxyl-groups (OH) and moisture from soot and tube by heating inside of quartz tube to 600° C.-1200° C. with introducing dehydration gases (He, Cl2; O2) into quartz tube, and sintering and vitrifying soot by heating quartz tube inside over 1700° C. with introducing dehydration gas (He, Cl2, O2); and (b) a step of forming at least one additional core layer on base core layer by repeating the accumulating/dehydrating/sintering of the step (a) at least one time.

Abstract: In order to automatically supply and locate a crash pad assembly in a vehicle by means of a robot in an automobile manufacturing plant, an automatic locating system of a crash pad for a vehicle according to the present invention comprises a synchronous running truck, a robot unit, first, second, third and fourth position detectors, first and second distance detectors, a limit switch, a vehicle-type detector, a vision controller, and a robot controller.

Abstract: The invention relates to a series of pyrrolopyrimidinone derivatives of the formula (1), processes for their preparation, intermediates in their preparation, their use as therapeutic agents, and pharmaceutical compositions containing them.

Abstract: In order to automatically supply and locate a crash pad assembly in a vehicle by means of a robot in an automobile manufacturing plant, an automatic locating system of a crash pad for a vehicle according to the present invention comprises a synchronous running truck, a robot unit, first, second, third and fourth position detectors, first and second distance detectors, a limit switch, a vehicle-type detector, a vision controller, and a robot unit.

Abstract: A vision processing method and device which processes a photographed-object image to provide information about a position and shape of the object, and perform the steps of forming a shape-memory contour model having a tendency to mention its original shape, the model being capable of changing its shape and position by an exterior operation; giving an outline of the shape-memory elastic contour model on the basis of an image of a photographed object; displacing the outlined contour model to an area expected to be occupied by the image of the photographed object; modifying the shape-memory elastic contour model in response to an exterior force generated in the image of the photographed object; and determining an image coordinate of the photographed object on the basis of the modified model.