Abstract: A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions.

Abstract: A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.

Abstract: A manual transmission for vehicles minimizes rotational inertia and improves rattle as a consequence of preventing unnecessary idling of a first speed gear and a reverse speed gear by maintaining a first input gear to be a free gear state at all shift-speeds except a first forward speed and a reverse speed.

Abstract: A biomarker Hsp90 for predicting an efficacy of a c-Met inhibitor, selecting a subject for application of a c-Met inhibitor, or monitoring an efficacy of a c-Met inhibitor, and a relevant method of using Hsp90.

Abstract: An anti-HER2 antibody, an anti-c-Met/anti-HER2 bispecific antibody including the same, method for preparing same, and a method of preventing and/or treating a cancer using the same are provided.

Abstract: An anti-EGFR/anti-HER3 antibody or antigen binding fragment thereof, and a method of preventing and/or treating a cancer using the same

Abstract: An anti-EGFR/anti-HER2 bispecific antibody including an anti-EGFR DARPin and an anti-HER2 antibody, a pharmaceutical composition including the bispecific antibody, a method of preparing the bispecific antibody, and a method of reducing a side effect and/or enhancing efficacy of an anti-HER2 antibody using an anti-EGFR DARPin.

Abstract: Pharmaceutical composition including a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor and a method of preventing and/or treating cancer including co-administering a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor to a subject in need thereof.

Abstract: An apparatus for damping a flywheel includes a drive plate integrally connected to a crankshaft. A flywheel is connected to receive a rotating force from the drive plate through planetary gearing, and is mounted to rotate relative to the crankshaft. A rigidity imparting means is disposed on a path along which a rotating force is transferred between the drive plate and the flywheel. A mass body is provided on the flywheel, and is configured to perform relative rotation in a direction that offsets a torsional vibration of an engine transmitted to the flywheel.

Abstract: A method of reducing rattle noise of a vehicle may include a coasting driving determination step of determining whether the vehicle is coasting, a fuel-in condition determination step of repeating the coasting driving determination step until a fuel-in condition is met when current RPM of an engine at a time at which it is determined that the vehicle is coasting is at least higher than fuel-in RPM of the engine, a minimum fuel-in step of performing a minimum fuel-in operation of supplying a minimum controllable unit of fuel when, at the fuel-in condition determination step, it is determined that the fuel-in condition is met, and a fuel-in repetition step of repeating the minimum fuel-in step a predetermined reference number of times within a range in which an angular acceleration amplitude increase rate of the engine does not exceed a predetermined reference increase rate by the minimum fuel-in operation.

Abstract: An anti-EGFR scFV fragment, an anti-c-Met/anti-EGFR bispecific antibody including the same, and a method of preventing and/or treating a cancer using the same are provided.

Abstract: A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.

Abstract: A method for controlling a clutch of an automatic transmission for improvement of fuel efficiency may include determining whether external driving conditions of a vehicle meets coasting conditions, determining a clutch slip control time and an amount of clutch slip torque according to internal driving conditions of the vehicle, performing slip control on a clutch that works at each step of the automatic transmission using the determined clutch slip control time and torque, wherein an engine brake torque transmitted to a final output shaft of the automatic transmission may be reduced.

Abstract: An automated manual transmission may include first and second auxiliary gears, wherein the first auxiliary gear is rotatably provided on an INPUT shaft to be rotated relatively with respect to the INPUT shaft and wherein the second auxiliary gear is provided on an OUTPUT shaft to be meshed with the first auxiliary gear, a planetary gear unit provided with three or more rotational elements wherein one rotational element thereof receives power from an engine to be rotated constantly and another rotational element thereof is coupled to the first auxiliary gear provided on the INPUT shaft to be rotated, and a motor generator that is coupled to still another rotational element of the rotational elements and provides a rotational power to the still another rotational element in shifting gears so that the rotational power is transmitted to the OUTPUT shaft through the first and second auxiliary gears.

Abstract: An inertia incremental apparatus for a flywheel of an engine, may include a drive plate integrally connected to a crankshaft, a flywheel rotatably connected to the camshaft, receiving a rotational force from the drive plate through a planetary gear set, and rotating relatively to the crankshaft, and a stiffness-providing unit disposed on a path of transmitting the rotational force from the drive plate to the flywheel.

Abstract: A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions.

Abstract: A clutch actuator for vehicles may include a lever lift engaged to a power generation unit so that the lever lift may be linearly moved by power generated from the power generation unit, wherein the lever lift includes an inclined surface provided on each of first and second ends thereof, and a lever provided between the lever lift and an actuating member that operates a diaphragm spring, wherein the lever includes lift protrusions formed at positions corresponding to respective inclined surfaces and contacting thereto, and wherein the lever may be configured such that when the lever lift linearly moves in a predetermined direction, the lift protrusions move along corresponding inclined surfaces, so that opposite ends of the lever pivotally rotate, whereby one of the opposite ends of the lever moves towards the actuating member.

Abstract: A manual transmission for vehicles minimizes rotational inertia and improves rattle as a consequence of preventing unnecessary idling of a first speed gear and a reverse speed gear by maintaining a first input gear to be a free gear state at all shift-speeds except a first forward speed and a reverse speed.

Abstract: An apparatus for parking control of an automatic transmission vehicle may include a speed detector that provides a controller with a vehicle speed, a shift lever detector that provides the controller with a position of a shift lever, the controller that analyses the vehicle speed and the position of the shift lever, and supplies a predetermined hydraulic pressure to brake elements and clutch elements in order to create drag on a parking gear shaft in conversion into a parking mode, and an actuator that supplies the hydraulic pressure to the clutch elements and the brake elements or discharges the hydraulic pressure from the clutch elements and the brake elements according to the control of the controller.

Abstract: There are provided an anti-c-Met/anti-EGFR bispecific antibody, a method for preventing and/or treating cancer using the same, and an anti-EGFR scFv fragment.