Patents by Inventor Jagadish C. Sircar

Jagadish C. Sircar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents
    Patent number: 5124347
    Abstract: The present invention is for selected novel compounds which are indoles substituted at the 3-position with [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene as well as pharmaceutical compositions and methods of use thereof. These compounds have activity useful in treating allergies, arthritis, and inflammation.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: June 23, 1992
    Assignee: Warner-Lambert Co.
    Inventors: David T. Connor, Ila Sircar, Jagadish C. Sircar
  • Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition
    Patent number: 5112868
    Abstract: The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.
    Type: Grant
    Filed: May 2, 1990
    Date of Patent: May 12, 1992
    Assignee: Warner-Lambert Company
    Inventors: Wiaczeslaw A. Cetenko, David T. Connor, Daniel L. Flynn, Jagadish C. Sircar
  • N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
    Patent number: 5112846
    Abstract: The present invention includes N-hydroxyamide, N-hydroxyurea, N-hydroxythioamide, and N-hydroxythiourea derivatives of fenamates, indomethacin, cicloprofen, oxepinac, and indoprofen as dual inhibitors or selective inhibitors of cyclooxygenase and 5-lipoxygenase.
    Type: Grant
    Filed: October 16, 1990
    Date of Patent: May 12, 1992
    Assignee: Warner-Lambert Company
    Inventors: Thomas R. Belliotti, Wiaczeslaw A. Cetenko, David T. Connor, Daniel L. Flynn, Catherine R. Kostlan, James B. Kramer, Jagadish C. Sircar
  • Method of treating gout with novel 9-deazaguanines
    Patent number: 5102879
    Abstract: The present invention is novel derivatives of pyrrolo[3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: April 7, 1992
    Assignee: Warner-Lambert Company
    Inventors: Catherine R. Kostlan, Jagadish C. Sircar
  • 3,5-ditertiarybutyl-4-hydroxyphenyl, 1,3,4-thiadiazoles and oxadiazoles linked by carbon, oxygen, and sulfur residues
    Patent number: 5102897
    Abstract: The novel 3,5-ditertiarybutyl-4-hydroxyphenylthio-1,3,4-thiadiazoles and oxadiazoles and 3,5-ditertiarybutyl-4-hydroxyphenylmethanone-1,3,4-thiadiazoles and oxadiazoles and related compounds of the present invention are antiinflammatory agents having activity as inhibitors of 5-lipoxygenase, cyclooxygenase or both.
    Type: Grant
    Filed: January 24, 1991
    Date of Patent: April 7, 1992
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Catherine R. Kostlan, James B. Kramer, Michael D. Mullican, Jagadish C. Sircar
  • 9-deazaguanines
    Patent number: 5101030
    Abstract: The present invention is novel derivatives of pyrrolo [3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: March 31, 1992
    Assignee: Warner-Lambert Company
    Inventors: Catherine R. Kostlan, Jagadish C. Sircar
  • 7-deazaguanines as immunomodulators
    Patent number: 5098905
    Abstract: The present invention is various 7-deazaguanines having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: November 15, 1990
    Date of Patent: March 24, 1992
    Assignee: Warner-Lambert Company
    Inventors: Thomas C. Malone, Jagadish C. Sircar
  • Purine derivatives
    Patent number: 5098906
    Abstract: Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.
    Type: Grant
    Filed: August 31, 1989
    Date of Patent: March 24, 1992
    Assignee: Warner-Lambert Company
    Inventors: Jagadish C. Sircar, Charles Schwender, Mark J. Suto
  • 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents
    Patent number: 5086064
    Abstract: The novel 3,5-di-tertiary-butyl-4-hydroxyphenylthiazolyl, -oxazolyl, or -imidazolyl methanones and methanone oximes of the present invention are antiinflammatory agents having activity as inhibitors of 5-lipoxygenase, cyclooxygenase or both.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: February 4, 1992
    Assignee: Warner-Lambert Company
    Inventors: Thomas Capiris, David T. Connor, Jagadish C. Sircar
  • N-hydroxyamide, N-hydroxythioamide, N-hydroxyurea, and N-hydroxythiourea derivatives of selected NSAIDS as antiinflammatory agents
    Patent number: 5075330
    Abstract: The present invention includes N-hydroxyamide, N-hydroxyurea, N-hydroxythioamide, and N-hydroxythiourea derivatives of fenamates, indomethacin, cicloprofen, oxepinac, and indoprofen as dual inhibitors or selective ihibitors of cyclooxygenase and 5-lipoxygenase.
    Type: Grant
    Filed: October 16, 1990
    Date of Patent: December 24, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Thomas R. Belliotti, Wiaczeslaw A. Cetenko, David T. Connor, Daniel L. Flynn, Catherine R. Kostlan, James B. Kramer, Jagadish C. Sircar
  • Triazole derivatives of fenamates as antiinflammatory agents
    Patent number: 5066668
    Abstract: The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use therefor. The nvention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: November 19, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Diane H. Boschelli, David T. Connor, Daniel L. Flynn, Jagadish C. Sircar, Milton L. Hoefle
  • 9-deazaguanines to treat psoriasis
    Patent number: 5061707
    Abstract: The present invention is novel derivatives of pyrrolo[3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: October 29, 1991
    Assignee: Warner-Lambert Company
    Inventors: Catherine R. Kostlan, Jagadish C. Sircar
  • "Pyrimidine derivatives"
    Patent number: 5051429
    Abstract: Novel purine derivatives, particularly novel guanines and hypoxanthines, are described as agents for treating autoimmune diseases. Also novel methods of manufacture for the derivatives, pharmaceutical compositions thereof, and methods of use therefor are the invention.
    Type: Grant
    Filed: December 15, 1989
    Date of Patent: September 24, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Garry W. Pinter, Jagadish C. Sircar
  • 7-deazaguanines as immunomodulators
    Patent number: 5002950
    Abstract: The present invention is various 7-deazaguanines having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: March 26, 1991
    Assignee: Warner-Lambert CO.
    Inventors: Thomas C. Malone, Jagadish C. Sircar
  • -2-Amino-4,6-dichloro-5-(2-cyanomethyl-2-amino-5(cy anomethyl)-4,6-dichloro pyrimidine
    Patent number: 4996319
    Abstract: The present invention is various 7-deazaguanines having activity as immunomodulators. Also included are pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: February 26, 1991
    Assignee: Warner-Lambert Company
    Inventors: Thomas C. Malone, Jagadish C. Sircar
  • Novel 9-deazaguanines
    Patent number: 4988702
    Abstract: The present invention is novel derivatives of pyrrolo[3,2-d]pyrimidines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-cells in the presence of 2'-deoxyguanosine and, therefore, are for use in the treatment of autoimmune diseases, gout, psoriasis or rejection of transplantation.
    Type: Grant
    Filed: February 12, 1990
    Date of Patent: January 29, 1991
    Assignee: Warner-Lambert Company
    Inventors: Catherine R. Kostlan, Jagadish C. Sircar
  • N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents
    Patent number: 4981865
    Abstract: The present invention includes N-hydroxyamide, N-hydroxyurea, N-hydroxythioamide, and N-hydroxythiourea derivatives of fenamates, indomethacin, cicloprofen, oxepinac, and indoprofen as dual inhibitors or selective inhibitors of cyclooxygenase and 5-lipoxygenase.
    Type: Grant
    Filed: May 26, 1989
    Date of Patent: January 1, 1991
    Assignee: Warner-Lambert Co.
    Inventors: Thomas R. Belliotti, Wiaczeslaw A. Cetenko, David T. Connor, Daniel L. Flynn, Catherine R. Kostlan, James B. Kramer, Jagadish C. Sircar
  • Triazole derivatives of fenamates as antiinflammatory agents
    Patent number: 4962119
    Abstract: The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: October 9, 1990
    Assignee: Warner-Lambert Company
    Inventors: Diane H. Boschelli, David T. Connor, Daniel L. Flynn, Jagadish C. Sircar, Milton L. Hoefle
  • Oxazolo-pyrimidine derivatives
    Patent number: 4952693
    Abstract: Novel purine derivatives, particularly novel guanines and hypoxanthines, are described as agents for treating autoimmune diseases. Also novel methods of manufacture for the derivatives, pharmaceutical compositions thereof, and methods of use therefor are the invention.
    Type: Grant
    Filed: December 15, 1987
    Date of Patent: August 28, 1990
    Assignee: Warner-Lambert Company
    Inventors: Jagadish C. Sircar, Garry W. Pinter
  • Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues and their use for cyclooxygenase and 5-lipoxygenase inhibition
    Patent number: 4943587
    Abstract: The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by the inhibition and methods for treating these conditions in mammals, including humans suffering therefor.
    Type: Grant
    Filed: May 19, 1988
    Date of Patent: July 24, 1990
    Assignee: Warner-Lambert Company
    Inventors: Wiaczeslaw A. Cetenko, David T. Connor, Daniel L. Flynn, Jagadish C. Sircar