Patents by Inventor Jai-Yoon Sul

Jai-Yoon Sul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transcriptome Transfer Produces Cellular Phenotype Conversion
    Publication number: 20140206059
    Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
    Type: Application
    Filed: March 31, 2014
    Publication date: July 24, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James Eberwine, Jai-Yoon Sul, Chia-Wen Wu, Fanyi Zeng, Junhyong Kim
  • Cytoplasmic BKchannel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons
    Patent number: 8536146
    Abstract: The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: September 17, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James Eberwine, Jai-Yoon Sul, Thomas J. Bell, Kevin Miyashiro
  • Methods for Transfecting Nucleic Acid Into Live Cells
    Publication number: 20120178167
    Abstract: The present invention includes methods for transferring a multigenic phenotype to a cell by transfecting, preferably by phototransfection, and locally transfecting a cell or a cellular process with a laser while the cell is bathed in a fluid medium comprising two or more nucleic acids, thereby introducing the nucleic acid into the interior of the cell. Expression of the nucleic acids results in a multigenic phenotype in the tranfected cell.
    Type: Application
    Filed: March 21, 2012
    Publication date: July 12, 2012
    Inventors: James Eberwine, Philip G. Haydon, Jai-Yoon Sul, Hajime Takano, Chia-Wen Kitty Wu, Fanyi Zeng
  • Methods for Phototransfecting Nucleic Acids Into Live Cells
    Publication number: 20120135493
    Abstract: The present invention includes methods for transferring a multigenic phenotype to a cell by transfecting, preferably by phototransfection, and locally transfecting a cell or a cellular process with a laser while the cell is bathed in a fluid medium comprising two or more nucleic acids, thereby introducing the nucleic acid into the interior of the cell. Expression of the nucleic acids results in a multigenic phenotype in the tranfected cell.
    Type: Application
    Filed: December 12, 2006
    Publication date: May 31, 2012
    Inventors: James Eberwine, Philip G. Haydon, Jai-Yoon Sul, Hajime Takano, Chia-Wen Kitty Wu, Fanyi Zeng
  • Transcriptome Transfer Produces Cellular Phenotype Conversion
    Publication number: 20120129261
    Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
    Type: Application
    Filed: July 19, 2011
    Publication date: May 24, 2012
    Inventors: James Eberwine, Jai-Yoon Sul, Tai Kyung Kim, Vickas Patel
  • Transcriptome Transfer Produces Cellular Phenotype Conversion
    Publication number: 20110033934
    Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
    Type: Application
    Filed: April 6, 2010
    Publication date: February 10, 2011
    Inventors: James Eberwine, Jai-Yoon Sul, Chia-Wen Wu, Fanyi Zeng, Junhyong Kim
  • Low Level Fluorescence Detection at the Light Microscopic Level
    Publication number: 20100216652
    Abstract: The present invention discloses methods of removing unwanted fluorescence from a sample by photobleaching said sample to enhance detection of proteins and fragments thereof, polynucleotides and fragments thereof, and biomolecules and fragments thereof in a sample by contacting said proteins, polynucleotides and biomolecules with a fluorescent reporter, wherein said fluorescent reported comprises a fluorescent semiconductor crystal or SCN, wherein said SCN further comprises a targeting moiety.
    Type: Application
    Filed: April 24, 2008
    Publication date: August 26, 2010
    Inventors: James H. Eberwine, Philip Haydon, Jai-Yoon Sul, Kevin Miyashiro, Thomas Bell
  • Cytoplasmic BKca Channel Intron-Containing mRNAs Contribute to the Intrinsic Excitability of Hippocampal Neurons
    Publication number: 20100203629
    Abstract: The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications.
    Type: Application
    Filed: April 25, 2008
    Publication date: August 12, 2010
    Inventors: James H. Eberwine, Jai-Yoon Sul, Thomas J. Bell, Kevin Miyashiro
  • Compositons, methods and kits for real-time nucleic acid analysis in live cells
    Publication number: 20100041025
    Abstract: The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms. The present invention further provides method for the rapid sequencing of nucleic acids without using conventional sequencing techniques or reactions.
    Type: Application
    Filed: May 17, 2006
    Publication date: February 18, 2010
    Inventors: James H Eberwine, Ülo Langel, Emelia Eiriksdóttir, Tina Peritz (nee Pajunen), Jai-Yoon Sul, Philip G. Haydon, Junhyong Kim