Patents by Inventor Jailall Ramnauth

Jailall Ramnauth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds, methods of making them and their use in therapy
    Patent number: 7790709
    Abstract: In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: September 7, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Judd M. Berman, Peter Sampson, Heinz W. Pauls, Jailall Ramnauth, David Douglas Manning, Matthew D. Surman, Dejian Xie, Helene Y. Decornez
  • ACRYLAMIDE DERIVATIVES AS FAB I INHIBITORS
    Publication number: 20100130470
    Abstract: In part, the present invention is directed to antibacterial compounds.
    Type: Application
    Filed: July 19, 2007
    Publication date: May 27, 2010
    Inventors: Heinz W. Pauls, Jailall Ramnauth, Peter Sampson, Andras Toro
  • Therapeutic agents, and methods of making and using the same
    Publication number: 20100093705
    Abstract: In part, the present invention is directed to antibacterial compounds.
    Type: Application
    Filed: June 6, 2005
    Publication date: April 15, 2010
    Inventors: Bruce J. Sargent, Henry Pauls, Judd M. Berman, Jailall Ramnauth, Peter Sampson, Andras Toro, Fernando J. Martin, Matthew D. Surman, Helene Y. Decornez, David D. Manning
  • BENZOXAZINES, BENZOTHIAZINES, AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY
    Publication number: 20100009975
    Abstract: The present invention features benzoxazines, benzothiazines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions.
    Type: Application
    Filed: July 6, 2009
    Publication date: January 14, 2010
    Inventors: Jailall Ramnauth, Subhash C. Annedi, Sarah Silverman, Peter Dove, Shawn Maddaford, Suman Rakhit
  • INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN
    Publication number: 20090192157
    Abstract: The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by administering to a patient in need thereof a therapeutically effective amount of an indole compound of Formula (I), or a pharmaceutically acceptable salt or prodrug thereof. The methods of the invention may further comprise the administration of additional therapeutic agent. The invention also features new compounds of Formula (I), pharmaceutical compositions thereof, and methods of resolving enantiomeric mixtures.
    Type: Application
    Filed: November 17, 2008
    Publication date: July 30, 2009
    Inventors: Shawn Maddaford, Jailall Ramnauth, Suman Rakhit, Joanne Patman, Paul Renton, Subhash C. Annedi, John S. Andrews, Gabriela Mladenova
  • 3,5 - SUBSTITUTED INDOLE COMPOUNDS HAVING NOS AND NOREPINEPHRINE REUPTAKE INHIBITORY ACTIVITY
    Publication number: 20090131503
    Abstract: The present invention relates to novel 3,5-substituted indole compounds of Formula (I) having nitric oxide synthase (NOS) inhibitory activity together with inhibitory activity at the norepinephrine transporter (NET), to pharmaceutical and diagnostic compositions containing them, and to their medical use.
    Type: Application
    Filed: November 17, 2008
    Publication date: May 21, 2009
    Inventors: Subhash C. Annedi, Shawn Maddaford, Jailall Ramnauth, Paul Renton, Suman Rakhit, John S. Andrews, Gabriela Mladenova
  • Salts, Prodrugs and Polymorphs of Fab I Inhibitors
    Publication number: 20090042927
    Abstract: In part, the present invention is directed to antibacterial compounds and salts thereof.
    Type: Application
    Filed: February 15, 2008
    Publication date: February 12, 2009
    Inventors: Henry Pauls, Jailall Ramnauth
  • SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY
    Publication number: 20080249302
    Abstract: The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, morphine/opioid induced tolerance and hyperalgesia.
    Type: Application
    Filed: March 13, 2008
    Publication date: October 9, 2008
    Applicant: NeurAxon Inc.
    Inventors: Shawn Maddaford, Jailall Ramnauth, Suman Rakhit, Joanne Patman, Paul Renton, Subhash C. Annedi
  • QUINOLONE AND TETRAHYDROQUINOLONE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY
    Publication number: 20080234237
    Abstract: The present invention features quinolones, tetrahydroquinolines, and related compounds that inhibit nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions.
    Type: Application
    Filed: March 24, 2008
    Publication date: September 25, 2008
    Inventors: Shawn MADDAFORD, Jailall RAMNAUTH, Suman RAKHIT, Joanne PATMAN, Subhash C. ANNEDI, John ANDREWS, Peter DOVE, Sarah SILVERMAN, Paul Renton
  • Substituted indole compounds having NOS inhibitory activity
    Patent number: 7375219
    Abstract: The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, morphine/opioid induced tolerance and hyperalgesia.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: May 20, 2008
    Assignee: NeurAxon, Inc.
    Inventors: Shawn Maddaford, Jailall Ramnauth, Suman Rakhit, Joanne Patman, Paul Renton, Subhash C. Annedi
  • Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation
    Patent number: 7375118
    Abstract: The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: May 20, 2008
    Assignee: Avanir Pharmaceuticals
    Inventors: Jagadish C. Sircar, Jailall Ramnauth, Mark L. Richards
  • 1,5 And 3,6- substituted indole compounds having NOS inhibitory activity
    Publication number: 20070254940
    Abstract: The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, or chronic pain.
    Type: Application
    Filed: April 13, 2007
    Publication date: November 1, 2007
    Inventors: Shawn Maddaford, Jailall Ramnauth, Suman Rakhit, Joanne Patman, Paul Renton, Subhash Annedi
  • Amino benzothiazole compounds with NOS inhibitory activity
    Patent number: 7141595
    Abstract: The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are useful for treating stroke and neuropathic pain.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: November 28, 2006
    Assignee: Neuraxon Inc.
    Inventors: Jailall Ramnauth, Suman Rakhit, Shawn Maddaford, Namrta Bhardwaj
  • Substituted indole compounds having NOS inhibitory activity
    Publication number: 20060258721
    Abstract: The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing conditions such as, for example, stroke, reperfusion injury, neurodegeneration, head trauma, CABG, migraine headache with and without aura, migraine with allodynia, central post-stroke pain (CPSP), neuropathic pain, morphine/opioid induced tolerance and hyperalgesia.
    Type: Application
    Filed: April 13, 2006
    Publication date: November 16, 2006
    Inventors: Shawn Maddaford, Jailall Ramnauth, Suman Rakhit, Joanne Patman, Paul Renton, Subhash Annedi
  • Heterocyclic compounds, methods of making them and their use in therapy
    Publication number: 20060183908
    Abstract: In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.
    Type: Application
    Filed: December 5, 2003
    Publication date: August 17, 2006
    Applicant: Affinium Pharmaceuticals, Inc.
    Inventors: Judd Berman, Peter Sampson, Heinz Pauls, Jailall Ramnauth, David Douglas, Matthew Surman, Dejian Xie, Helene Decornez
  • Amino benzothiazole compounds with NOS inhibitory activity
    Publication number: 20050209291
    Abstract: The present invention provides novel amino benzothiazole compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds described in the present invention are useful for treating stroke and neuropathic pain.
    Type: Application
    Filed: November 24, 2004
    Publication date: September 22, 2005
    Inventors: Jailall Ramnauth, Suman Rakhit, Shawn Maddaford, Namrta Bhardwaj
  • Tricyclic compounds with NOS activity
    Patent number: 6919328
    Abstract: The present invention provides novel tricyclic compounds, compositions comprising these compounds and methods of using these compounds as neuroprotectants. In particular, the compounds of the invention are useful for treating stroke.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: July 19, 2005
    Assignee: Neuraxon Inc.
    Inventors: Suman Rakhit, Jailall Ramnauth, Svetoslav Bratovanov, Shawn Maddaford
  • Phenyl-indole compounds for modulating IgE and inhibiting cellular proliferation
    Publication number: 20040180946
    Abstract: The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic. This invention also relates to phenyl-indole molecules that are cellular proliferation inhibitors and thus are useful as anticancer agents. This invention further relates to small molecules which suppress cytokines and leukocytes.
    Type: Application
    Filed: September 12, 2003
    Publication date: September 16, 2004
    Inventors: Jagadish C. Sircar, Jailall Ramnauth, Mark L. Richards