Abstract: The present disclosure describes composite actuator piston rods and methods for making such rods. Composite actuator piston rods of the present disclosure may include a composite actuator rod tube having a flared end, an insert, wherein the insert has a complementary shape to the flared end, a piston head concentrically surrounding the flared end of the composite actuator rod tube, and a piston head nut configured to threadingly attach to the piston head.

Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: An abrasive recycling system is provided. The abrasive recycling system includes a vacuum, wherein the vacuum is variably positioned in relation to a mixture of dry abrasive and foreign material and is configured to extract foreign material from the mixture during abrasive recycling performed by an abrasive recycler. Methodology corresponding to the removal of foreign objects by an abrasive recycling system is also provided.

Abstract: The present disclosure provides a composite material comprising: a composite substrate comprising a polymeric matrix with fibre reinforcement. A surface of the composite substrate is coated with a conductive layer comprising conductive particles, preferably dispersed in a polymeric matrix. The composite substrate and the conductive layer are bonded together via polymeric crosslinking.

Abstract: The “Dreador” is a energy saving, novel design, durable, lightweight, compact and portable It is a hairstyling Tool that would ease the task of tightening, locking, and sealing dreadlocks. It would offer greater control while twisting hair into Dreadlocks. This tool would provide a more attractive and professional result. The “Dreador” is approximately 3 inches in width and about 5 inches in length and ½ an inch thick. It has a worm screw in the center of the apparatus, it also has teeth near the handles that interlock For clamping hair, it also has rubber pads for gripping hair while twisting it and a swivel nob for this two step process. Dreador would be wrought from aluminum alloy using hammer forging or drop forging alloyed with zinc, copper or nickel for strength and corrosion. A manufacturer would determine the most effective forging process.

Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: Disclosed herein are compositions and methods of treating osteoporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: A host server is configured to receive information related to metrics and configurations associated with computer resources of a computer infrastructure, derive and resolve the information into capacity, performance, reliability, and efficiency, as related to attributes associated with the computer resources, including compute attributes such as application, virtual machine (VM) attributes, storage attributes, and network attributes. The host server provides the metrics and attributes in a matrix configuration as a graphical user interface (GUI) on an output device, such as a display. The GUI is configured to provide a user with a single point of view into the computer infrastructure by converging application, compute, storage, and network attributes into capacity, performance, reliability, and efficiency concepts. With such a configuration, the GUI allows the end user to readily review the environments for potential issues in a time efficient manner, as well as solutions provided by the GUI.

Abstract: The present invention relates to novel bone compositions for locally delivering a therapeutic agent to the site of a bone defect. Therapeutic agents may promote repair of the bone defect and/or treat conditions or disorders such as pain, inflammation, cancer, and infection. The compositions include calcium phosphate cements and a demineralized bone matrix or a collagen sponge. The compositions are useful for implantation in a patient at the site of a bone defect.

Abstract: An abrasive recycling system is provided. The abrasive recycling system includes a vacuum, wherein the vacuum is variably positioned in relation to a mixture of dry abrasive and foreign material and is configured to extract foreign material from the mixture during abrasive recycling performed by an abrasive recycler. Methodology corresponding to the removal of foreign objects by an abrasive recycling system is also provided.

Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.

Abstract: The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R1, R4, R5, R6, and L1 are as defined herein. Compounds of formula (IA) have been found useful as EP4 receptor agonists useful in the treatment of glaucoma, osteoporosis, neuropathic pain, and related disorders.

Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: Multiheteroaryl compounds, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical use in the prevention and treatment of prostaglandin D2 mediated diseases and conditions that may be modulated by the inhibition of hematopoietic prostaglandin D synthase (H-PGDS).

Abstract: Disclosed herein are compositions and methods of treating osteoporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: The invention comprises a process comprising infiltrating or infiltrating and coating a substrate with a boron-comprising precursor, and contacting the boron-comprising precursor with a nitrogen-comprising reactant to convert the boron-comprising precursor to BN or other a boron-nitrogen reaction product in the surface porosity or in the surface porosity and on the surface of the substrate. Composite materials comprising as one phase a substrate and BN or other a boron-nitrogen reaction product as a further phase, in surface porosity or in surface porosity and on a surface of the substrate, are claimed.

Abstract: A method of interactive gaming includes identifying a broadcast event, generating interactive questions for the broadcast event based upon a subject of the broadcast event, organizing the generated questions based on a structure of the broadcast event, and providing the organized questions to a user during a broadcast of the broadcast event through an interactive gaming interface based on the structure of the broadcast event.