Abstract: Compounds having the formula I wherein A, m and R1 are herein defined are Hepatitis C virus NS5b polymerase inhibitors.

Abstract: A single antenna element with a switchable extension may be used to change the size of the radiating surface and provide an antenna that has two or more separate center frequencies. The range of frequencies that may be tuned by the antenna is enhanced, while maintaining relatively low complexity tuning and matching circuitry. Switching for the extension is performed by a switching element that is located at the point of connection of the extension to the antenna element. A control line supplies a control signal to the switching element to enable and disable the extension. The control line is positioned in close proximity to the antenna element to enhance coupling between the antenna element and the control line.

Abstract: Accommodating the data needed to process checks for payment under the Check Clearing for the 21st Century Act by using expanded fields of a financial data file. The financial data file can comprise the complete, original MICR data from an original or substitute paper check. The financial data file can comprise truncated data in conventional fields F1-F7 and untruncated data in expanded fields F10-F11. The financial data file further can comprise a result from an image quality analysis performed on an electronic image of the check. The untruncated MICR data and the electronic check image can be used to correct errors in the financial data file and to present the check for payment via a substitute check or an electronic image cash letter. The truncated MICR data can be used to electronically process the check via conventional means.

Abstract: The present invention provides, an antenna test device to test antenna efficiency. The test device includes a cavity formed by at least one conductive sidewall. The cavity contains at least one tuning probe, at least one movable portion, or a combination thereof. The tuning probes and/or movable portion help inhibit the antenna under test from having faulty measurements due to anti resonance or coupling.

Abstract: The present invention provides a method to measure antenna efficiency using the cavity method. In particular, the present invention provides a tunable cavity that can be tuned to avoid the anti resonance and antenna-cavity coupling problems. In particular, tuning probes and/or variable volumetric sizing of the cavity are used to tune the cavity to avoid the anti resonance and antenna-cavity coupling.

Abstract: An exemplary WDM coupling device may include optical fibers. The coupling device may also include region(s) having varying coefficients of thermal expansion. During a temperature variation, one or more of the region(s) may alter in size to substantially cancel temperature-dependent changes associated with the WDM coupling device.

Abstract: Compounds having the formula I wherein A, m and R1 are herein defined are Hepatitis C virus polymerase inhibitors. Also disclosed are compositions and methods for treating diseases mediated by HCV and for inhibiting hepatitis replication.

Abstract: Disclosed are methods of treating inflammatory diseases and disorders, such as arthritis and inflammatory bowel disease, in mammals.

Abstract: My invention, the Shear Wall Aspect Ratio Reducing Frame is a simple, economical, efficient, easy to install device that allows greater oppotunity and flexibility in the size and location of openings in the walls of wood frame constructed buildings particularly houses. The ARRF would replace the commercial, pre-fabricated systems now in use which are costly and inefficient labor-intensive shear wall devices. The ARRF achieves its goal by reducing the moment arm in the overturning equations that are used to determine the uplift forces in a shear wall. The ARRF reduces forces in walls rather than increase their bulk which is the strategic concept now in use throughout the design professions and the construction industry to solve the aspect ratio problem.

Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specifications. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract: Assessing the quality of an electronic image comprises determining a quality rating for the electronic image, associating image quality thresholds with purposes for electronic images, selecting the purpose that corresponds to the electronic image, identifying an image quality threshold associated with the selected purpose, and determining whether the quality rating meets the image quality threshold. The electronic image is suitable for its intended purpose if its quality rating meets the threshold.

Abstract: An electrically heated chemical delivery system including a heat sensitive chemical and an electrical heater adjacent to the heat sensitive chemical. The heater includes a heater element with a first heater side and a second heater side and a flexible printed circuit in electrical contact with both the first heater side and the second heater side. The flexible printed circuit includes at least one fold allowing electrical contact with both the first heater side and the second heater side.

Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract: A method and system for adjusting power at output ports of a wavelength division multiplexing (WDM) coupler. A loss element may be placed at one or more of the output ports of the WDM coupler. The loss element may have a filter characteristic that matches the temperature sensitivity coefficient of the WDM coupler. The filter characteristic may reject power at one of the two output ports as a function of temperature. As a result, the loss element may balance the power at the output ports of the WDM coupler despite temperature variations.

Abstract: A time division multiplexed optical voltage measuring system includes an optical voltage sensing system module including, (i) a plurality of optical sensors where each sensor is responsive to an input interrogation light wave, and (ii) one or more optical outputs affected by sensed electric field thereat. The optical voltage sensing system module includes an optical circuit arrangement having (i) an input for receiving a module specific pulsed light wave derived from a primary pulsed light wave from a remote light source, and (ii) arranged such that each of the plurality of optical sensors receives an interrogation pulsed light wave. The optical circuit arrangement of the optical voltage sensing system module further includes at least one optical wave combiner for combining like-kind of outputs from all of the plurality of optical sensors. The optical circuit is arranged such that the pulsed light waves from the outputs of different optical sensors arrive at the optical wave combiner at differing times.

Abstract: An ion transport membrane system comprising (a) a pressure vessel having an interior, an exterior, an inlet, and an outlet; (b) a plurality of planar ion transport membrane modules disposed in the interior of the pressure vessel and arranged in series, each membrane module comprising mixed metal oxide ceramic material and having an interior region and an exterior region, wherein any inlet and any outlet of the pressure vessel are in flow communication with exterior regions of the membrane modules; and (c) one or more gas manifolds in flow communication with interior regions of the membrane modules and with the exterior of the pressure vessel. The ion transport membrane system may be utilized in a gas separation device to recover oxygen from an oxygen-containing gas or as an oxidation reactor to oxidize compounds in a feed gas stream by oxygen permeated through the mixed metal oxide ceramic material of the membrane modules.

Abstract: A system (10) for storing and using information associated with geographic locations of interest to a mobile user comprises a mobile apparatus (100) and a remote apparatus (200). The mobile apparatus accepts and transmits information associated with a mobile user's geographic position. The remote apparatus (200) receives the transmitted information, stores the information along with data indicative of the position and time as a waypoint, and allows the user to retrieve and manipulate waypoints. The system is preferably realized as a vehicle information system (20) that allows a vehicle user to store waypoints descriptive of different locations encountered during travel. Each waypoint includes the geographic position of its corresponding location, the time, and may include appended information such as a voice message or a picture. The waypoints are stored in a remote server accessible from both the vehicle and an auxiliary apparatus such as a standard telephone (310) or a personal computer (330).