Abstract: Provided are polypeptides, nucleic acids, vectors, cells and compositions useful for treating bacterial infections, particularly bacterial vaginosis (BV) and related conditions, particularly endolysin polypeptides derived from Gardnerella spp. Also provided is use of amino acid sequences to create a chimeric polypeptide having anti-Gardnerella spp. activity. Methods of treatment using the polypeptides, nucleic acids, vectors, cells and compositions are also provided.

Abstract: Techniques are disclosed for processing a workflow campaign. In some embodiments, a message processing service receives a first message that corresponds to a user arriving at a first node of the workflow campaign from a first message queue. The message processing service causes one or more actions associated with the first node to be performed with respect to the user. In addition, the message processing service determines that the first user should be progressed from the first node to a second node of the workflow campaign. The message processing service generates a second message that corresponds to the user arriving at the second node and determines a second message queue that is associated with the second node. The message processing service progresses the user from the first node to the second node by transmitting the second message to the second message queue.

Abstract: The present disclosure provides technologies for modulating microbiome of mammalian subjects (e.g., human subjects). The present disclosure, among others, provides therapeutic compositions and methods of using the same, wherein the therapeutic compositions comprising an engineered population of therapeutic bacteria that (i) are non-pathogenic and commensal in a subject to be administered; and (ii) are resistant to one or more target bacteriophages. In some embodiments, such therapeutic compositions can be useful for treatment of subjects suffering from or susceptible to a microbiome-dysfunction-associated disease, disorder, or condition (e.g., inflammatory bowel disease).

Abstract: Abstract Provided are polypeptides, nucleic acids, vectors, cells and compositions useful for treating bacterial infections, particularly bacterial vaginosis (BV) and related conditions, particularly endolysin polypeptides derived from Gardnerella spp. Also provided is use of amino acid sequences to create a chimeric polypeptide having anti-Gardnerella spp. activity. Methods of treatment using the polypeptides, nucleic acids, vectors, cells and compositions are also provided.

Abstract: Systems and methods for secure digital asset transactions. An offline system includes a custodian computer, digital asset accounts accessible by the custodian computer and a centralized ledger maintained by the custodian computer. The custodian computer is in communication with public ledger computers of a public ledger, and receives transaction data associated with digital assets from among entity computers. Each account is prefunded with digital asset funds. The custodian computer monitors a transaction parameter of the transaction data and, in accordance with the monitoring, generates a transfer instruction indicating transfer of funds between the first and second accounts, updates the centralized ledger responsive to the transfer instruction, and transfers the funds between the first and second accounts, responsive to the transfer instruction. The transfer instruction remains offline and is not transferred to the public ledger.

Abstract: A vehicle bumper system includes a vehicle that has a front end, a bottom side and a pair of front wheels. A bumper is mounted to the front end of the vehicle to absorb impact energy from a collision. The bumper is positioned lower than the bottom side of the vehicle to frictionally engage ground when the vehicle travels over a depression. In this way the bumper inhibits the bottom side of the vehicle from engaging the ground. The bumper has a first well and a winch is selectively mounted therein.

Abstract: A method and a non-transient computer readable medium for sorting orders to be run on a multi-section slitter/scorer at a corrugator dry end includes collecting specifications of orders in current, prior, and/or subsequent paper group queues. Run times and slit/score head recovery times for orders in the current paper group queue are calculated using the specifications. Those orders for which recovery time exceeds run time are flagged as short orders. For a given short order, pairs of preceding and following orders that would require recovery times less than the short order's run time are determined and flagged as potential bracketing pairs. The current paper group queue is searched to determine if a bracketing pair can be formed from its orders, and if so, the orders in the current paper group queue are reorganized such that the orders in the bracketing pair immediately precede and follow the given short order.

Abstract: A block of a solid lubricant material, such as PTFE, is biased continuously or intermittently against the cutting edge of a rotary slitting blade for corrugated paperboard. The solid lubricant block prevents the build up of starch adhesive and biasing movement compensates for wear of the block and wear of the cutting blade edge.

Abstract: A method for automatically setting the rider roll/glue applicator roll gap for the single face web on a glue machine senses a forward drag that the single face web, operating at corrugator speed, exerts on the glue applicator roll, driven at an underspeed, after bringing the flute tips of the single face web into contact with the glue applicator roll by adjusting the position of the rider roll. Changes in forward drag exerted on the glue applicator roll are monitored and related directly to glue applicator roll drive current to provide a slight compression of the single face web between the rider roll and the glue applicator roll. Preferably, the glue applicator roll uses a regenerative drive and the target drive current command in a feedback control system to cause the gap to be adjusted to achieve the desired slight compression of the web flutes and to maintain the glue applicator roll under speed.

Abstract: A method and a non-transient computer readable medium for sorting orders to be run on a multi-section slitter/scorer at a corrugator dry end includes collecting specifications of orders in current, prior, and/or subsequent paper group queues. Run times and slit/score head recovery times for orders in the current paper group queue are calculated using the specifications. Those orders for which recovery time exceeds run time are flagged as short orders. For a given short order, pairs of preceding and following orders that would require recovery times less than the short order's run time are determined and flagged as potential bracketing pairs. The current paper group queue is searched to determine if a bracketing pair can be formed from its orders, and if so, the orders in the current paper group queue are reorganized such that the orders in the bracketing pair immediately precede and follow the given short order.

Abstract: A method and apparatus for performing an order change in a corrugator uses a minimum slit head configuration with all slit heads carried on two sides of a single tool support structure. A single robot is operable on the support structure to independently reset the positions of slit heads during a running order to prepare for subsequent order change in a most efficient manner, utilizing order scheduling that eliminates order changes that cannot be formed with the minimum slit head configuration.

Abstract: A block of a solid lubricant material, such as PTFE, is biased continuously or intermittently against the cutting edge of a rotary slitting blade for corrugated paperboard. The solid lubricant block prevents the build up of starch adhesive and biasing movement compensates for wear of the block and wear of the cutting blade edge.

Abstract: A block of a solid lubricant material, such as PTFE, is biased continuously or intermittently against the cutting edge of a rotary slitting blade for corrugated paperboard. The solid lubricant block prevents the build up of starch adhesive and biasing movement compensates for wear of the block and wear of the cutting blade edge.

Abstract: A pressure diffuser washer comprising: an outer wall, an inner wall adjacent to the outer wall, the inner wall defining annular baffle chambers between the outer wall and the inner wall, wherein each of the annular baffle chambers is configured to connect to a source of a wash liquid, a reciprocating screen assembly adjacent to the inner wall, the reciprocating screen assembly defining a first annular chamber between the inner wall and the reciprocating screen assembly, an area in the inner wall defining a gap associated with each of the annular baffle chambers, wherein the wash liquid from an annular baffle chamber flows through the gap into the first annular chamber, and an annular baffle screen plate covering the gap, wherein the annular baffle screen plate defines openings sized to prevent rocks and other large particulate debris from entering the annular baffle chambers.

Abstract: A pressure diffuser washer comprising: an outer wall, an inner wall adjacent to the outer wall, the inner wall defining annular baffle chambers between the outer wall and the inner wall, wherein each of the annular baffle chambers is configured to connect to a source of a wash liquid, a reciprocating screen assembly adjacent to the inner wall, the reciprocating screen assembly defining a first annular chamber between the inner wall and the reciprocating screen assembly, an area in the inner wall defining a gap associated with each of the annular baffle chambers, wherein the wash liquid from an annular baffle chamber flows through the gap into the first annular chamber, and an annular baffle screen plate covering the gap, wherein the annular baffle screen plate defines openings sized to prevent rocks and other large particulate debris from entering the annular baffle chambers.

Abstract: A method for automatically setting the rider roll/glue applicator roll gap for the single face web on a glue machine senses a forward drag that the single face web, operating at corrugator speed, exerts on the glue applicator roll, driven at an underspeed, after bringing the flute tips of the single face web into contact with the glue applicator roll by adjusting the position of the rider roll. Changes in forward drag exerted on the glue applicator roll are monitored and related directly to glue applicator roll drive current to provide a slight compression of the single face web between the rider roll and the glue applicator roll. Preferably, the glue applicator roll uses a regenerative drive and the target drive current command in a feedback control system to cause the gap to be adjusted to achieve the desired slight compression of the web flutes and to maintain the glue applicator roll under speed.

Abstract: A method and apparatus for performing an order change in a corrugator uses a minimum slit head configuration with all slit heads carried on two sides of a single tool support structure. A single robot is operable on the support structure to independently reset the positions of slit heads during a running order to prepare for subsequent order change in a most efficient manner, utilizing order scheduling that eliminates order changes that cannot be formed with the minimum slit head configuration.

Abstract: A method for automatically setting the rider roll/glue applicator roll gap for the single face web on a glue machine senses a forward drag that the single face web, operating at corrugator speed, exerts on the glue applicator roll, driven at an underspeed, after bringing the flute tips of the single face web into contact with the glue applicator roll by adjusting the position of the rider roll. Changes in forward drag exerted on the glue applicator roll are monitored and related directly to glue applicator roll drive current to provide a slight compression of the single face web between the rider roll and the glue applicator roll. Preferably, the glue applicator roll uses a regenerative drive and the target drive current command in a feedback control system to cause the gap to be adjusted to achieve the desired slight compression of the web flutes and to maintain the glue applicator roll under speed.

Abstract: A method and apparatus for performing an order change in a corrugator uses a minimum slit head configuration with all slit heads carried on two sides of a single tool support structure. A single robot is operable on the support structure to independently reset the positions of slit heads during a running order to prepare for subsequent order change in a most efficient manner, utilizing order scheduling that eliminates order changes that cannot be formed with the minimum slit head configuration.

Abstract: Method and apparatus for operating a corrugator wet end splicing of three short orders between a longer first order and a longer fifth order utilizes a primary splicer and a tandem splicer in which the first two short order webs from paper rolls on the tandem splicer can be prepared for splice while the first longer order is running by threading the first of the short order webs from the tandem splicer to the primary splicer for splice preparation on the primary splicer and preparing the second short order for splice on the tandem splicer. The first and second short order webs are spliced on the primary and tandem splicer, respectively, immediately after completion of the longer first order. The third short order web is provided by a fourth roll mounted on the roll stand for the primary splicer immediately after completion of the longer first order.