Abstract: Methods and systems for verifying authority in distributed systems are disclosed. Authority may be delegated to various entities within a distributed system to invoke performance of operations within the distributed systems. To verify that authority has been delegated, a security framework may be used that limits computing resource consumption for the verifications. The computing resource consumption may be limited by using cryptographically verifiable data structures that establish chains of delegation of authority. The cryptographically verifiable data structures may be limited in size and content to reduce the computational cost for implementing the security framework.

Abstract: An artificial lift system utilizing a downhole impeller-style pump and a motor at the surface. The system includes a centralizer for use with the rod string or tubing. The centralizer centralizes a rotating rod at intermediate points within the tubing string. The centralizer includes a plurality of flexure springs and bearings. A rod string tensioner induces a tension load on the rod string.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: Systems, media, and methods for automated response to social queries comprising: monitoring queries from users, each query submitted to a vendor via an interactive chat feature of an external electronic communication platform, monitoring human responses to the queries, monitoring subsequent communications conducted via the electronic communication platform until each query is resolved; applying a first machine learning algorithm to the monitored communications to identify a query susceptible to response automation; applying a second machine learning algorithm to the query susceptible to response automation to identify one or more responses likely to resolve the query; and either i) notifying a human to respond to the query susceptible to response automation with the one or more responses likely to resolve the query, or ii) instantiating an autonomous software agent configured to respond to the query susceptible to response automation with the one or more responses likely to resolve the query.

Abstract: Embodiments of negative pressure wound therapy systems, apparatuses, and methods for operating the systems and apparatuses are disclosed. In some embodiments, the apparatus includes a negative pressure source, a connector port, at least one switch, and a controller. The negative pressure source is connected through the connector port to either (i) a wound dressing having a canister configured to store fluid aspirated from the wound or (ii) a wound dressing without a canister between the connector port and the wound dressing. The controller determines, based on a signal received from the at least one switch, whether the canister is positioned in the fluid flow path and adjusts one or more operational parameters of negative pressure wound therapy based on the determination. The switch is activated by the connection of either the canister or canisterless wound dressing to the apparatus.

Abstract: A user-activity video signal can be received. The user-activity video signal can comprise a video capture characterizing a user's interaction with a software application on a client. The software application can have an interface display space on the client and the software application can execute on the client in operation with at least one remote backend computing system. Backend user interaction data corresponding to the user's interaction with the software application as generated by the at least one remote backend computing system can be received. A new video comprising a plurality of divided segments of the user-activity video signal can be generated automatically using the backend user interaction data and a plurality of predefined rules. The new video can be provided. Related apparatus, systems, techniques, and articles are also described.

Abstract: A system and method are provided for storing and recovering electricity generated from conventional/renewable energy sources. A thermal energy storage vessel contains thermal storage fluid (“TSF”) comprising a eutectic ternary nitrate molten salt, induction heating elements, turbine pumps, a heat exchanger, and various data acquisition sensors like thermocouples and thermistors. The immersion heating elements receive the electricity generated from conventional and/or renewable energy source to heat the eutectic ternary nitrate molten salt to the desired temperature. Coiled tubing is deployed within the thermal containment vessel to be distribution systems for the power cycle working gas and heat exchange for the power cycle working gas. The power cycle working gas is delivered under pressure to a steam turbine or a gas turbine or industrial heat. The turbine converts the energy into mechanical shaft work to drive an electricity generator to produce electricity.

Abstract: The present invention relates to a resorcinol derivative as a pharmaceutically active compound and method of preparation thereof. Resorcinol derivatives have been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the resorcinol derivative of the invention.

Abstract: A heat exchange system includes cooling tubes that carry coolant and are placed on an external surface of a storage tank, which may be spherical, cylindrical, or other shape. The storage tank may be a cryogenic rocket fuel tank. The cooling tubes are bent to particular radius of curvatures that correspond to the varying curvatures of the storage tank. A network of spacers and bridge brackets with adjustable setscrews are used to precisely place the cooling tubes in correct positions on the external surface of the storage tank. Once placed in the desired position, the setscrews are adjusted to maximize the surface area contact between the cooling tubes and the exterior surface of the storage tank, resulting in optimal heat transfer without overstressing the materials of the tubing or the storage tank. The precisely positioned tubes may then be permanently affixed to the exterior surface of the storage tank using a cryogenic adhesive.

Abstract: The present invention relates to novel lipidated peptide inhibitors of the interleukin-23 receptor (IL-23R) or pharmaceutically acceptable salts, solvates and/or other forms thereof, corresponding pharmaceutical compositions, methods and/or uses of the IL-23R inhibitors for treatment of autoimmune inflammation diseases and/or related disorders.

Abstract: A battery tray can include a first member having a first lower portion and a first upper portion. The first lower portion can support a battery with a first insulative element positioned between the first lower portion and the battery. The first upper portion can couple with the battery with a second insulative element positioned between the battery and the first upper portion. The battery tray can include a second member having a second lower portion and a second upper portion. The second lower portion can support the battery with a third insulative element positioned between the second lower portion and the battery. The second upper portion can couple with the battery with a fourth insulative element positioned between the battery and the second upper portion.

Abstract: A battery energy storage system can include an enclosure including a panel to provide access to a cavity defined by the enclosure. The battery energy storage system a frame positioned within the cavity. The frame can include a first rail to accommodate a first battery tray coupled with a first battery of a first battery type and a second rail to accommodate a second battery tray coupled with a second battery of a second battery type. A dimension of the first battery type is different than a dimension of the second battery type.

Abstract: Provided herein are non-naturally occurring, broadly reactive, pan-epitopic antigens derived from Dengue virus that are immunogenic and elicit a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against Dengue virus subtypes following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, immunogenic compositions, vaccines, subviral particles (SVPs), and virus-like particles (VLPs) comprising Dengue virus proteins or encoding polynucleotides. Methods of generating an immune response in a subject by administering the immunogens, vaccines, SVPs, VLPs, or immunogenic compositions thereof are provided. In particular, the immunogens comprise a Dengue virus protein, or an antibody binding portion thereof.

Abstract: A centralizer for use in high speed rotor dynamics applications includes a housing having a first end portion and a second end portion. The centralizer further includes a rotatable shaft positioned within a cavity of the housing. The centralizer also includes flexure springs that are each attached to and extend between the first end portion and the second end portion. The flexure springs are compressible toward a middle portion of the housing that is between the first end portion and the second end portion. The centralizer further includes roller wheels attached to the flexure springs.

Abstract: A user-activity video signal can be received. The user-activity video signal can comprise a video capture characterizing a user's interaction with a software application on a client. The software application can have an interface display space on the client and the software application can execute on the client in operation with at least one remote backend computing system. Backend user interaction data corresponding to the user's interaction with the software application as generated by the at least one remote back-end computing system can be received. A new video comprising a plurality of divided segments of the user-activity video signal can be generated automatically using the backend user interaction data and a plurality of predefined rules. The new video can be provided. Related apparatus, systems, techniques, and articles are also described.

Abstract: In one embodiment, the disclosed technology involves a system having a generator set comprising a first engine and an output terminal coupled to a power distributor, a load comprising two or more sub-loads, wherein each of the sub-loads are coupled to the power distributor via one or more respective electrical contactors, and a controller communicably coupled to the electrical contactors and the generator set comprising a processor, and a memory, the memory having computer-readable instructions stored thereon that, when executed by the processor cause operations. The operations may include determining a number of sub-loads available, receiving data representing power generation of the generator set, determining which of the available sub-loads to connect in order to balance the generator set to the load, and controlling the respective electrical contactors of the determined sub-loads so as to provide electricity to the determined sub-loads.

Abstract: The present invention relates to a multipurpose drill system, the multipurpose drill system comprising: a drilling rig adapted to drive a drilling assembly; and two or more power sources, wherein at least one of the two or more power sources is a high pressure power source, wherein the drilling assembly is adapted to be in communication with either or both of the two or more power sources.

Abstract: A system and method are provided for storing and recovering electricity generated from conventional/renewable energy sources. A thermal energy storage vessel contains thermal storage fluid (“TSF”) comprising a eutectic ternary nitrate molten salt, induction heating elements, turbine pumps, a heat exchanger, and various data acquisition sensors like thermocouples and thermistors. The immersion heating elements receive the electricity generated from conventional and/or renewable energy source to heat the eutectic ternary nitrate molten salt to the desired temperature. Coiled tubing is deployed within the thermal containment vessel to be distribution systems for the power cycle working gas and heat exchange for the power cycle working gas. The power cycle working gas is delivered under pressure to a steam turbine. The turbine converts the energy into mechanical shaft work to drive an electricity generator to produce electricity.