Patents by Inventor James A. Ernst

James A. Ernst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-transferrin receptor antibodies and methods of use
    Patent number: 11098129
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: August 24, 2021
    Assignee: Genentech, Inc.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S Dennis, James A Ernst, Ryan J Watts, Gregory A Lazar
  • Anti-transferrin receptor / anti-BACE1 multispecific antibodies and methods of use
    Patent number: 11008403
    Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: May 18, 2021
    Assignees: Genentech, Inc., Adimab LLC
    Inventors: Yichin Liu, Jasvinder Atwal, Cecilia Pui Chi Chiu, Ryan J. Watts, Yan Wu, Eric Krauland, Michael Feldhaus, Yin Zhang, Joy Yu Zuchero, Jessica Couch, Mark S Dennis, James A Ernst, Gregory A Lazar
  • ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
    Publication number: 20210087288
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Application
    Filed: September 1, 2020
    Publication date: March 25, 2021
    Applicant: Genentech, Inc.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S. Dennis, James A. Ernst, Ryan J. Watts, Gregory A. Lazar
  • Anti-transferrin receptor antibodies and methods of use
    Patent number: 10808036
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: October 20, 2020
    Assignee: GENENTECH, INC.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S. Dennis, James A. Ernst, Ryan J. Watts, Gregory A. Lazar
  • Anti-Transferrin Receptor Antibodies and Methods of Use
    Publication number: 20200123267
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Application
    Filed: October 31, 2019
    Publication date: April 23, 2020
    Applicant: Genentech, Inc.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S Dennis, James A Ernst, Ryan J Watts, Gregory A Lazar
  • Anti-transferrin receptor antibodies and methods of use
    Patent number: 10508151
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Grant
    Filed: November 18, 2015
    Date of Patent: December 17, 2019
    Assignee: Genentech, Inc.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S Dennis, James A Ernst, Ryan J Watts, Gregory A Lazar
  • ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
    Publication number: 20180134797
    Abstract: The present invention relates to anti-trans-ferrin receptor antibodies and methods of their use.
    Type: Application
    Filed: November 18, 2015
    Publication date: May 17, 2018
    Applicant: Genentech, Inc.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S Dennis, James A Ernst, Ryan J Watts, Gregory A Lazar
  • ANTI-TRANSFERRIN RECEPTOR / ANTI-BACE1 MULTISPECIFIC ANTIBODIES AND METHODS OF USE
    Publication number: 20180057604
    Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
    Type: Application
    Filed: November 18, 2015
    Publication date: March 1, 2018
    Applicants: Genentech, Inc., Adimab LLC
    Inventors: Yichin Liu, Jasvinder Atwal, Cecilia Pui Chi Chiu, Ryan J. Watts, Yan WU, Eric Krauland, Michael Feldhaus, Yin Zhang, Joy Yu Zuchero, Jessica Couch, Mark S Dennis, James A Ernst, Gregory A Lazar
  • ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
    Publication number: 20180002433
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Application
    Filed: June 5, 2017
    Publication date: January 4, 2018
    Applicant: Genentech, Inc.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S. Dennis, James A. Ernst, Ryan J. Watts, Gregory A. Lazar
  • WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS
    Publication number: 20170349639
    Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
    Type: Application
    Filed: December 20, 2016
    Publication date: December 7, 2017
    Applicant: Genentech, Inc.
    Inventors: James A. ERNST, Paul POLAKIS, Bonnee RUBINFELD, Venita I. DEALMEIDA
  • Anti-transferrin receptor antibodies and methods of use
    Patent number: 9708406
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: July 18, 2017
    Assignee: GENENTECH, INC.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S. Dennis, James A. Ernst, Ryan J. Watts, Gregory A. Lazar
  • ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE
    Publication number: 20150110791
    Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
    Type: Application
    Filed: May 20, 2014
    Publication date: April 23, 2015
    Applicant: GENENTECH, INC.
    Inventors: Yin Zhang, Joy Yu Zuchero, Jasvinder Atwal, Jessica Couch, Mark S. Dennis, James A. Ernst, Ryan J. Watts, Gregory A. Lazar
  • Methods for producing soluble membrane-spanning proteins
    Patent number: 8323902
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: December 4, 2012
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
  • WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS
    Publication number: 20120141481
    Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
    Type: Application
    Filed: February 7, 2012
    Publication date: June 7, 2012
    Inventors: James A. Ernst, Paul Polakis, Bonnee Rubinfeld, Venita I. DeAlmeida
  • WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS
    Publication number: 20110311534
    Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
    Type: Application
    Filed: May 23, 2011
    Publication date: December 22, 2011
    Applicant: Genentech, Inc.
    Inventors: James A. Ernst, Paul Polakis, Bonnee Rubinfeld, Venita I. DeAlmeida
  • Wnt antagonists and their use in the diagnosis and treatment of Wnt-mediated disorders
    Patent number: 7947277
    Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: May 24, 2011
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Paul Polakis, Bonnee Rubinfeld, Venita I. DeAlmeida
  • Methods for producing soluble membrane-spanning proteins
    Patent number: 7829684
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: November 9, 2010
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
  • Methods for producing soluble membrane spanning proteins
    Patent number: 7820806
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: October 26, 2010
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim
  • WNT ANTAGONISTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF WNT-MEDIATED DISORDERS
    Publication number: 20100266593
    Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
    Type: Application
    Filed: June 29, 2010
    Publication date: October 21, 2010
    Applicant: Genentech, Inc.
    Inventors: James A. Ernst, Paul Polakis, Bonnee Rubinfeld, Venita I. DeAlmeida
  • Methods for producing soluble membrane-spanning proteins
    Patent number: 7691989
    Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: April 6, 2010
    Assignee: Genentech, Inc.
    Inventors: James A. Ernst, Daniel Yansura, Hok Seon Kim