Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

Abstract: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.

Abstract: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.

Abstract: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.

Abstract: A method for determining the speed of at least one rotating fan, such as a propeller, through sensing pressure waves generated by the blades of the fan. An apparatus operable to execute the method is also disclosed. The apparatus includes a fan having a hub portion and a plurality of blades extending radially outward from the hub portion. The apparatus also includes an engine operable to rotate the fan about an axis of rotation. The apparatus also includes a sensor spaced from the fan along the axis of rotation. The sensor is positioned to sense at least one physical condition that is external of the engine and is changed by rotation of the plurality of blades. The sensor is operable to emit a signal corresponding to at least one physical condition. The apparatus also includes a processor operably engaged with the engine and the sensor. The processor is operable to receive the signal from the sensor and change the operation of the engine in response to the signal to change a speed of the fan.

Abstract: A reconfigurable FADEC includes a reconfigurable CPU configured for performing digital computing functions. A reconfigurable MSPD communicates with the CPU and is configured for performing analog I/O functions. A data bus is coupled to the CPU and the MSPD. The data bus is configured for connecting the CPU and the MSPD to an external connector.

Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.

Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.

Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.

Abstract: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.

Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.

Abstract: A method for determining the speed of at least one rotating fan, such as a propeller, through sensing pressure waves generated by the blades of the fan. An apparatus operable to execute the method is also disclosed. The apparatus includes a fan having a hub portion and a plurality of blades extending radially outward from the hub portion. The apparatus also includes an engine operable to rotate the fan about an axis of rotation. The apparatus also includes a sensor spaced from the fan along the axis of rotation. The sensor is positioned to sense at least one physical condition that is external of the engine and is changed by rotation of the plurality of blades. The sensor is operable to emit a signal corresponding to at least one physical condition. The apparatus also includes a processor operably engaged with the engine and the sensor. The processor is operable to receive the signal from the sensor and change the operation of the engine in response to the signal to change a speed of the fan.

Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.

Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.

Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.

Abstract: The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.

Abstract: Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.