Patents by Inventor James A. Glazier
James A. Glazier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10973686Abstract: This disclosure relates to methods for treatment or prevention of retinal vascular disease by photocoagulation. More specifically, this disclosure relates to an improved technique for the placement of retinal burns so as to prevent the development of hypoxia and progression of ischemia in retinal tissue, including the macula. The methods can also be employed to prevent potential ischemic tissue damage in diabetic, pre-diabetic or other patients with ischemic retinal vascular disease, or those at risk of ischemic retinal vascular disease.Type: GrantFiled: January 20, 2017Date of Patent: April 13, 2021Assignee: The Trustees of Indiana UniversityInventors: Thomas J. Gast, Xiao Fu, James A. Glazier
-
Patent number: 10821437Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: GrantFiled: August 20, 2018Date of Patent: November 3, 2020Assignee: The Trustees of Indiana UniversityInventors: James A. Glazier, Stephen C. Jacobson, Dragos Amarie
-
Patent number: 10456404Abstract: Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific phosphodiesterase inhibitors for preventing the progression and/or treatment of cystic kidney diseases. Other aspects described provide medicaments for preventing the progression and/or treating cystic kidney diseases, and methods of diagnosing cystic kidney disease.Type: GrantFiled: March 14, 2016Date of Patent: October 29, 2019Assignees: Indiana University Research and Technology Corporation, United States Government as Represented by the Department of Veterans AffairsInventors: Robert Bacallao, James A. Glazier, Sherry G. Clendenon, Rita Maria Cunha De Almeida
-
Publication number: 20190192345Abstract: This disclosure relates to methods for treatment or prevention of retinal vascular disease by photocoagulation. More specifically, this disclosure relates to an improved technique for the placement of retinal burns so as to prevent the development of hypoxia and progression of ischemia in retinal tissue, including the macula. The methods can also be employed to prevent potential ischemic tissue damage in diabetic, pre-diabetic or other patients with ischemic retinal vascular disease, or those at risk of ischemic retinal vascular disease.Type: ApplicationFiled: January 20, 2017Publication date: June 27, 2019Inventors: Thomas J. Gast, Xiao Fu, James A. Glazier
-
Publication number: 20190136169Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: ApplicationFiled: December 28, 2018Publication date: May 9, 2019Applicant: Indiana University Research and Technology CorporationInventors: James A. Glazier, Abdelkrim Alileche, Abbas Shirinifard, Dragos Amarie
-
Patent number: 10196596Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: GrantFiled: February 22, 2016Date of Patent: February 5, 2019Assignee: National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR)Inventors: James A. Glazier, Abdelkrim Alileche, Abbas Shirinifard, Dragos Amarie
-
Publication number: 20190009273Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: ApplicationFiled: August 20, 2018Publication date: January 10, 2019Inventors: James A. GLAZIER, Stephen C. JACOBSON, Dragos AMARIE
-
Patent number: 10052628Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: GrantFiled: June 30, 2016Date of Patent: August 21, 2018Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Stephen C. Jacobson, Dragos Amarie
-
Publication number: 20180229059Abstract: A system and method for a coupling housing. The housing houses a coupling, such as a cable. The housing is coupled to a lift via an attaching device. The coupling can be lowered down to secure to ground equipment. This allows a stranded lift, such as a ski lift, to be properly secured to the ground equipment. This allows for the safe and efficient removal of any stranded passengers.Type: ApplicationFiled: February 9, 2018Publication date: August 16, 2018Inventor: James Glazier
-
Publication number: 20180078559Abstract: Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific phosphodiesterase inhibitors for preventing the progression and/or treatment of cystic kidney diseases. Other aspects described provide medicaments for preventing the progression and/or treating cystic kidney diseases, and methods of diagnosing cystic kidney disease.Type: ApplicationFiled: March 14, 2016Publication date: March 22, 2018Applicant: Indiana University Research and Technology CoporationInventors: Robert Bacallao, James A. Glazier, Sherry G. Clendenon, Rita Maria Cunha De Almeida
-
Publication number: 20160310945Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: ApplicationFiled: June 30, 2016Publication date: October 27, 2016Inventors: James A. GLAZIER, Stephen C. JACOBSON, Dragos AMARIE
-
Patent number: 9440207Abstract: Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311, 312, 313, and 314) oriented among bifurcated (5), trifurcated (6) and merging junctions (7 and 8). The apparatus splits and merges fluids flowing in the channels to produce successive dilutions of the fluids within the outlet channels. Multiple apparatus may be combined in serial, parallel, combined serial and parallel and/or stacked configurations. One or more apparatus may be used alone or to provide various devices or chambers with the diluted fluids.Type: GrantFiled: September 18, 2008Date of Patent: September 13, 2016Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Stephen C. Jacobson, Dragos Amarie
-
Publication number: 20160168523Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: ApplicationFiled: February 22, 2016Publication date: June 16, 2016Inventors: James A. GLAZIER, Abdelkrim ALILECHE, Abbas SHIRINIFARD, Dragos AMARIE
-
Patent number: 9267099Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: GrantFiled: March 15, 2011Date of Patent: February 23, 2016Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Abdelkrim Alileche, Abbas Shrinifard, Dragos Amarie
-
Patent number: 8355136Abstract: Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.Type: GrantFiled: June 13, 2011Date of Patent: January 15, 2013Assignee: Indiana University Research and Technology CorporationInventors: James A. Glazier, Dragos Amarie
-
Publication number: 20130004469Abstract: Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined geometries and ECM and basement membrane associated with the capillary networks. The capillary networks and the ECM and basement membrane detachable from the capillary networks are useful for tissue engineering applications.Type: ApplicationFiled: March 15, 2011Publication date: January 3, 2013Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: James A. Glazier, Abdelkrim Alileche, Abbas Shrinifard, Dragos Amarie
-
Patent number: 8169615Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: GrantFiled: May 26, 2011Date of Patent: May 1, 2012Assignee: Indiana University Research & Technology CorporationInventors: James A. Glazier, Dragos Amarie
-
Publication number: 20110257494Abstract: Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.Type: ApplicationFiled: June 13, 2011Publication date: October 20, 2011Inventors: James A. Glazier, Dragos Amarie
-
Publication number: 20110228277Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single microchip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: ApplicationFiled: May 26, 2011Publication date: September 22, 2011Inventors: James A. GLAZIER, Dragos Amarie
-
Patent number: 7961330Abstract: A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements is mounted is described. A multi-channel sensor for detecting the presence of several targets with a single micro-chip sensor is described. A multi-channel sensor including collections of SPR elements which are commonly functionalized to one of several targets is also described. The detectors sense changes in the resonant response of the SPR elements indicative of binding with the targets.Type: GrantFiled: March 31, 2010Date of Patent: June 14, 2011Assignee: Indiana University Research & Technology CorporationInventors: James A. Glazier, Dragos Amarie