Abstract: Provided herein are methods of reducing the incident of disease flares in a subject in need thereof.

Abstract: The systems, devices, articles, and methods described herein generally relate to analog computers, for example quantum processors comprising qubits, couplers, and, or cavities. Analog computers, for example quantum processor based computers, are the subject of various sources of error which can hinder operation, potentially reducing computational accuracy and speed. Sources of error can be broadly characterized, for example as i) a background susceptibility do to inherently characteristics of the circuitry design, ii) as an h/J ratio imbalance, iii) bit flip errors, iv) fidelity, and v) Anderson localization, and various combinations of the aforesaid.

Abstract: Provided herein are methods of treating diabetic kidney disease comprising administering a therapeutically effective amount of atrasentan, or a pharmaceutically acceptable salt thereof, and a SGLT-2 inhibitor to a subject in need thereof.

Abstract: Systems and methods are described for operating a hybrid computing system using cluster contraction for converting large, dense input to reduced input that can be easily mapped into a quantum processor. The reduced input represents the global structure of the problem. Techniques involve partitioning the input variables into clusters and contracting each cluster. The input variables can be partitioned using an Unweighted Pair Group Method with Arithmetic Mean algorithm. The quantum processor returns samples based on the reduced input and the samples are expanded to correspond to the original input.

Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.

Abstract: A hybrid computing system for solving a computational problem includes a digital processor, a quantum processor having qubits and coupling devices that together define a working graph of the quantum processor, and at least one nontransitory processor-readable medium communicatively coupleable to the digital processor which stores at least one of processor-executable instructions or data. The digital processor receives a computational problem, and programs the quantum processor with a first set of bias fields and a first set of coupling strengths. The quantum processor generates samples as potential solutions to an approximation of the problem. The digital processor updates the approximation by determining a second set of bias fields based at least in part on the first set of bias fields and a first set of mean fields that are based at least in part on the first set of samples and coupling strengths of one or more virtual coupling devices.

Abstract: A method and system for adhering roofing products to a supporting roof substrate, wherein ballast rock from a pre-existing roof insulation system is removed thereby exposing one or more layers of pre-existing insulation products supported by the roof substrate. In the case of new construction, the method contemplates installation of one or more layers of insulation products supported by the roof substrate. Core holes are formed through the one or more layers of insulation products thereby exposing the roof substrate.

Abstract: A highly parallelized parallel tempering technique for simulating dynamic systems, such as quantum processors, is provided. Replica exchange is facilitated by synchronizing grid-level memory. Particular implementations for simulating quantum processors by representing cells of qubits and couplers in grid-, block-, and thread-level memory are discussed. Parallel tempering of such dynamic systems can be assisted by modifying replicas based on isoenergetic cluster moves (ICMs). ICMs are generated via secondary replicas which are maintained alongside primary replicas and exchanged between blocks and/or generated dynamically by blocks without necessarily being exchanged. Certain refinements, such as exchanging energies and temperatures through grid-level memory, are also discussed.

Abstract: Systems and methods are described for operating a hybrid computing system using cluster contraction for converting large, dense input to reduced input that can be easily mapped into a quantum processor. The reduced input represents the global structure of the problem. Techniques involve partitioning the input variables into clusters and contracting each cluster. The input variables can be partitioned using an Unweighted Pair Group Method with Arithmetic Mean algorithm. The quantum processor returns samples based on the reduced input and the samples are expanded to correspond to the original input.

Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.

Abstract: Provided herein are methods of reducing the incident of disease flares in a subject in need thereof.

Abstract: Provided herein are methods of inhibiting mesangial cell activation in a subject in need thereof.

Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.

Abstract: Provided herein are methods of treating kidney diseases in a subject in need thereof.

Abstract: Innovations in game design features of an electronic gaming device are presented. A progressive jackpot is associated with an escrow. At least a portion of the escrow can be applied to a reset amount for the progressive jackpot. The amount of escrow applied to the reset amount can vary, such as based on a current escrow value. The progressive jackpot can be associated with an increment rate and an escrow rate. The increment rate or the escrow rate may vary based on one or more parameters, including one or more game parameters. Game parameters can include game output parameters, such as a coin out amount, a number of games played, a handpay amount, or a number of players actively engaged in game play with a particular progressive jackpot. Changes in how escrow is applied, or how increment or escrow rates are determined, can be based on time periods or events.