Abstract: A strike indicator that indicates when a fish bites and reduces false positives, comprising a light source, a power source, a printed circuit board, an accelerometer integrated circuit mounted on said printed circuit board, and a microcontroller mounted on said printed circuit board. The strike indicator may be housed in a fishing rod, with the light source illuminating the tip of the rod. The accelerometer detects acceleration of the rod, and the microcontroller utilizes an algorithm to determine whether the acceleration is due to a fish biting or due to other causes. If the acceleration is due to a fish biting, the light source is activated, alerting the user that a fish is biting.

Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Abstract: Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue.

Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.

Abstract: A phacoemulsification needle sleeve 10 includes an elongated, resilient tubular body portion 18 having a distal end 20. An enlarged section 22 is formed on a proximal end of the body portion 18 for surrounding a hub of a needle 12. The distal end 20 is formed to abut a proximal end 24 of a flared end 14 of the needle 12. An outer diameter of the body portion 18 is essentially equal to an outer diameter of the flared end 14 so that the sleeve 10 is easily inserted through an incision 54 in a patient's eye.

Abstract: A length of ophthalmic surgical irrigation tubing 14 includes an inner lumen 18 for transporting fluid from a source 24 to a surgical handpiece 26. The tubing 14 has an outer surface 20 including reinforcement structure 22 formed on the outer surface 20 along the length of the tubing 14. The reinforcement structure 22 provides support to the length of tubing 14 to resist kinking of the tubing 14 during surgery.

Abstract: A length of ophthalmic surgical irrigation tubing 14 includes an inner lumen 16 for transporting fluid from a source 24 to a surgical handpiece 26. The inner lumen 16 is formed by an inner shell 18. A flexible outer shell 20 spans and surrounds a length of the inner shell 18. A plurality of flexible webs 22 is connected between the inner shell 18 and the outer shell 20. The combination of the outer shell and the webs provide support to the inner shell to resist kinking of the inner shell during surgery.

Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.

Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Abstract: An integrated customer fulfillment management (ICFM) system allows a user to request a fulfillment package to be delivered to a recipient using a computing system. The fulfillment request, specifying personal information about the recipient is specified. The content of the fulfillment package is selected, which may include a communication personalized to the recipient, such as a letter, an e-mail, a link to a personalized web page, or other content. The content of the fulfillment package also may include one or more documents, such as literature regarding a good or service, or an article, such as a gift or another item requested or needed by the user. The fulfillment request is directed to a fulfillment center for preparation of the fulfillment package. The fulfillment center is able to access personal information about the recipient to generate the personalized letter, prepare the fulfillment package, and facilitate shipping of the fulfillment package.

Abstract: A length of ophthalmic surgical irrigation tubing 14 includes an inner lumen 18 for transporting fluid from a source 24 to a surgical handpiece 26. The tubing 14 has an outer surface 20 including reinforcement structure 22 formed on the outer surface 20 along the length of the tubing 14. The reinforcement structure 22 provides support to the length of tubing 14 to resist kinking of the tubing 14 during surgery.

Abstract: A length of ophthalmic surgical irrigation tubing 14 includes an inner lumen 16 for transporting fluid from a source 24 to a surgical handpiece 26. The inner lumen 16 is formed by an inner shell 18. A flexible outer shell 20 spans and surrounds a length of the inner shell 18. A plurality of flexible webs 22 is connected between the inner shell 18 and the outer shell 20. The combination of the outer shell and the webs provide support to the inner shell to resist kinking of the inner shell during surgery.

Abstract: A musical sonification system and method sonifies data, such as real-time financial market data, to produce an audio signal output including a musical rendering of the data. A sonification engine converts the data into sound parameters based on configuration data and a sonification and mapping scheme. A sound generator generates the audio output signal from the sound parameters.

Abstract: Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue.

Abstract: A length of tubing 20 includes an irrigation lumen 26 for carrying irrigation fluid from a source 12 to an ophthalmic surgical site at eye 18. An aspiration lumen 28 is also formed in tubing 20 for carrying aspirant from the surgical site at eye 18 to a collection reservoir. The irrigation lumen 26 and the aspiration lumen 28 include a compliant common wall 30. Wall 30 ensures that any surge occurring after an occlusion break during surgery is dampened because of the compliant common wall 30.

Abstract: A phacoemulsification needle sleeve 10 includes an elongated, resilient tubular body portion 18 having a distal end 20. An enlarged section 22 is formed on a proximal end of the body portion 18 for surrounding a hub of a needle 12. The distal end 20 is formed to abut a proximal end 24 of a flared end 14 of the needle 12. An outer diameter of the body portion 18 is essentially equal to an outer diameter of the flared end 14 so that the sleeve 10 is easily inserted through an incision 54 in a patient's eye.

Abstract: Multi-ply tissue products are disclosed. The multi-ply tissue products contain tissue webs that have raised areas and depressed areas. The tissue webs may be constructed so as to be relatively non-compressive and may have a resilient three-dimensional structure. During production, in one embodiment, the tissue webs may be produced without being subjected to any substantial compression, such as a calendering process. Although not necessary in all applications, in one embodiment, the tissue webs may be combined such that the depressed areas contact each other to form the multi-ply product. The tissue webs, for instance, may comprise a through-air dried web in which the raised areas and the depressed areas are molded into the web. Tissue products made according to the present invention have enhanced absorption characteristics. For instance, the tissue products can have an interply absorbency of greater than about 3 g/g after 30 seconds.

Abstract: An ophthalmic phacoemulsification irrigation sleeve 26 includes an elongated resilient tubular body portion 28 having a distal end 30 and a proximal end 32 for surrounding a portion of a shaft of a pharcoemulsification needle. An enlarged section 34 is formed on the proximal end 32 for surrounding a hub of a needle and for connection to a phacoemulsification handpiece. Adjacent to the tubular body portion distal end 30 at least one non-circular irrigation port is formed. The shape of the port includes a radiused leading edge closest to the distal end 30 and has tapering, trailing sides 40 resulting in a trailing end 42 having smaller radius than the leading edge radius.

Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.