Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient. These compounds are therefore useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, cancer cachexia, muscular dystrophies, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Abstract: A seating unit is provided having a base, a back frame pivoted to the base for movement between upright and reclined positions, and a seat slidably supported on the base assembly and pivoted to the back frame so that the seat moves forwardly and its rear moves forwardly and downwardly with the back frame upon recline. A flexible back shell is connected to the back frame at top and bottom locations for controlled flexure when a seated user reclines and/or flexes his/her back, and is provided with lumbar adjustment for improved lumbar force/support and shape.

Abstract: Compounds of structural formula I as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of activating the function of the androgen receptor in a patient, and in particular the method wherein the function of the androgen receptor is blocked in the prostate of a male patient or in the uterus of a female patient and activated in bone and/or muscle tissue.

Abstract: A peristaltic pump 10 for use in ophthalmic surgery includes a housing 12, a pump head 14 having plurality of rollers 16, a backing plate 18 attached to the housing 12, and a length of surgical tubing 50. The rollers 16 and backing plate 18 cooperate to pinch the length of surgical tubing 50 to peristaltically pump fluids from a surgical site to a collection bag 64. At least one of the pump head 14 and the backing plate 18 is moveable, during operation of the pump 10, from a tubing pinched position to a tubing vent position. This movement allows the tubing 50 to be vented by removing the pinched closure of the tubing 50.

Abstract: A phacoemulsification cannula 10 includes a hub 18 for engagement with a surgical instrument 30. An elongated needle 12 has a proximal end 14 attached to the hub 18 and a distal end 16. The needle 12 has first and second inner diameters 22 and 24. The first inner diameter 22 is larger than the second inner diameter 24, and a transition 26 from the first inner diameter 22 to the second inner diameter 24 is closer to the proximal end 14 than to the distal end 16.

Abstract: A method of making wet rolls includes providing a web of material, applying a wetting solution to the web to produce a wet web, and winding the wet web into a roll. The wetting solution may include an inorganic salt and at least one preservative. The wetting solution may be distributed evenly throughout the wet roll.

Abstract: The specification discloses a method for treatment of contaminated groundwater. According to one embodiment, the method includes as a first step extracting a contaminated subterranean fluid from a contaminated well. The fluid is then stripped by passing the fluid through an inline stripper so that volatile contaminants are transferred from a liquid phase to a vapor phase. Next, the liquid phase and the vapor phase are separated into two process streams. The volatile contaminants are then recovered from the vapor phase process stream, destroyed, or if permissible, discharged from the vapor stream. The invention may suitably be used in the treatment of subterranean fluids which are extracted as a two-phase flow or in the treatment of which are substantially a liquid phase having volatile contaminants dissolved therein.

Abstract: A seating unit includes a seat and back operably supported for synchronized reclining movement. The back includes a back support with separate upper and lower portions pivotally coupled to a back frame at upper and lower connections, respectively. The upper and lower portions combine to define a forwardly-protruding convex shape and include mating structure forming an expansion joint that permits collapse and expansion as the upper and lower portions are flexed between a more-convex shape and a more-planar shape. In one form, the lower portion includes first and second sections pivoted together, with the upper portion and the first and second sections forming thoracic, lumbar, and pelvic regions of the back support, respectively.

Abstract: A seating unit is provided having a base, a back frame pivoted to the base for movement between upright and reclined positions, and a seat slidably supported on the base assembly and pivoted to the back frame so that the seat moves forwardly and its rear moves forwardly and downwardly with the back frame upon recline. A flexible back shell is connected to the back frame at top and bottom locations for controlled flexure when a seated user reclines and/or flexes his/her back, and is provided with lumbar adjustment for improved lumbar force/support and shape.

Abstract: A seating unit includes a seat and back operably supported for synchronized reclining movement. The back includes a back support with separate upper and lower portions pivotally coupled to a back frame at upper and lower connections, respectively. The upper and lower portions combine to define a forwardly-protruding convex shape and include mating structure forming an expansion joint that permits collapse and expansion as the upper and lower portions are flexed between a more-convex shape and a more-planar shape. In one form, the lower portion includes first and second sections pivoted together, with the upper portion and the first and second sections forming thoracic, lumbar, and pelvic regions of the back support, respectively.

Abstract: A back construction for a seating unit includes a back frame, and a compliant back having a forwardly-protruding lumbar support section that is characteristically flexible and bendable, such that the compliant back can be flexed to a plurality of different convex shapes. Top and bottom connections pivotally connect the compliant back to the back frame. An adjustable force-generating mechanism is operably attached to at least one of the compliant back and the back frame. The force-generating mechanism is constructed to provide an adjustable biasing force that adjustably biases the lumbar support section forwardly for optimal lumbar support for a seated user's back, but the force-generating mechanism characteristically provides the biasing force without forcing a shape change in the compliant back. A vertically adjustable lumbar support is slidably attached to the back shell.

Abstract: A seating unit includes a flexible back including a concavely-shaped lumbar region, and a tensioned cover stretched over the concavely-shaped lumbar region. A lumbar device is fit between the front surface and the covering, with a tension of the covering biasing the lumbar device against the lumbar region and resulting in a frictional force retaining the lumbar device in a selected vertical position. In one form, the lumbar device is sufficiently stiff to maintain its vertical cross sectional shape and to change a shape of the lumbar region as the lumbar device is adjusted vertically, but is sufficiently flexible to conform to a horizontal shape of the lumbar region as a seated user moves and twists while seated in the seating unit.

Abstract: A back for a seating unit, such as a chair, includes a back frame and a compliant back that is flexibly bendable to define different curvilinear shapes for sympathetically and ergonomically supporting a seated user's back. The back includes a bracket with forwardly-extending flanges pivotally connecting the compliant back to the back frame at a bottom connection generally aligned with a seated user's hip joint. The back also includes a top connection pivotally connecting the back to the back frame above the first connection. An adjustable torsional force-generating mechanism is connected to the first connection that biases a lumbar portion of the compliant back forward with respect to the chair. The top and bottom connections, in combination with the adjustable force generating mechanism, constrain the compliant back to move over a range that provides excellent ergonomic lumbar support to a seated user.

Abstract: A back for a seating unit, such as a chair, includes a back frame and a compliant back that is flexibly bendable to define different curvilinear shapes for sympathetically and ergonomically supporting a seated user's back. The back includes a belt bracket with forwardly-extending flanges pivotally connecting the back to the back frame at a first connection generally aligned with a seated user's hip joint. The back includes a second connection pivotally connecting the back to the back frame at a second location spaced vertically above the first connection. An adjustable force generating mechanism is connected to the first connection that biases a lumbar portion of the back forward with respect to the chair. The first and second connections, in combination with the adjustable force generating mechanism, constrain the compliant back to move over a range that provides excellent ergonomic lumbar support to a seated user.

Abstract: A seating unit is provided having a base assembly, a back frame pivoted to the base assembly for movement between upright and reclined positions, and a seat slidably supported on the base assembly and pivoted to the back frame so that the seat moves forwardly and its rear moves forwardly and downwardly with the back frame upon recline. A flexible back is connected to the back frame at top and bottom locations and is provided with lumbar adjustment for improved lumbar force/support and shape. A seat is provided with seat depth adjustment and with active and passive thigh flex support. A novel energy mechanism is provided that includes a moment arm shift adjuster for adjusting the spring tension on the back frame. The moment arm shift adjuster is readily adjustable and includes an overtorque device to prevent damage to components of the energy mechanism.

Abstract: A back construction for a seating unit includes a back frame, and a compliant back having a forwardly-protruding lumbar support section that is characteristically flexible and bendable, such that the compliant back can be flexed to a plurality of different convex shapes. Top and bottom connections pivotally connect the compliant back to the back frame. An adjustable force-generating mechanism is operably attached to at least one of the compliant back and the back frame. The force-generating mechanism is constructed to provide an adjustable biasing force that adjustably biases the lumbar support section forwardly for optimal lumbar support for a seated user's back, but the force-generating mechanism characteristically provides the biasing force without forcing a shape change in the compliant back. A vertically adjustable lumbar support is slidably attached to the back shell.

Abstract: A back for a seating unit, such as a chair, includes a back frame and a compliant back that is flexibly bendable to define different curvilinear shapes for sympathetically and ergonomically supporting a seated user's back. The back includes a bracket with forwardly-extending flanges pivotally connecting the compliant back to the back frame at a bottom connection generally aligned with a seated user's hip joint. The back also includes a top connection pivotally connecting the back to the back frame above the first connection. An adjustable torsional force-generating mechanism is connected to the first connection that biases a lumbar portion of the compliant back forward with respect to the chair. The top and bottom connections, in combination with the adjustable force generating mechanism, constrain the compliant back to move over a range that provides excellent ergonomic lumbar support to a seated user.

Abstract: A chair is provided having a base assembly, a back assembly pivoted to the base assembly for movement between upright and reclined positions, and a seat slidably supported on the base assembly and pivoted to the back frame so that the seat moves forwardly and its rear moves forwardly and downwardly with the back frame upon recline. A flexible back is connected to the back frame at top and bottom locations and is provided with lumbar adjustment for improved lumbar force/support and shape. A seat is provided with seat depth adjustment and with active and passive thigh flex support. A novel energy mechanism is provided that includes a moment arm shift adjuster for adjusting the spring tension on the back frame. The moment arm shift adjuster is readily adjustable and includes an overtorque device to prevent damage to components of the energy mechanism.

Abstract: A hydraulic system for use in a resistance welding machine with a stationary electrode and a variable electrode to provide adjustment of the stationary electrode to ensure proper positioning to maintain weld quality. The hydraulic system comprising an actuated piston attached to the stationary electrode, a motive piston to control the flow of hydraulic fluid in the hydraulic system, a hydraulic locking device to lock the stationary electrode in a stationary position to resist forces during the welding operation and a pneumatic control system to operate the hydraulic system.

Abstract: A system for monitoring the integrity of a cable, for example a cable for towing a variable depth sonar body through the ocean, is described. Such a cable comprises a core of electrical wires surrounded by load bearing wires which are secured to the sonar body through a terminator. For various reasons cracks can appear in the load bearing wires and in extreme cases one or more of the wires may break. The monitoring system includes a transducer located near the terminator where the wires are most likely to crack or break and acoustic emissions caused by the incidence of cracks or breaks are picked up by the transducer. The resulting electrical signals are amplified and passed up the electrical core of the cable to the towing vessel where they are processed. Novel aspects of the system are the water coupling between the location of the cracks or breaks and the transducer and special processing circuitry which enables breaks, cracks and electrical noise to be distinguished from each other.