Patents by Inventor James A. Shayman

James A. Shayman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20070072916
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: September 15, 2006
    Publication date: March 29, 2007
    Applicant: The Regents of the University of Michigan
    Inventor: James Shayman
  • Synthesis of UDP-glucose: -acylsphingosine glucosyltransferase inhibitors
    Patent number: 7196205
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: March 27, 2007
    Assignees: The Regents of the University of Michigan, Genzyme Corporation
    Inventors: Craig Siegel, James A. Shayman, Carol A. Nelson, David J. Harris, Diane P. Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 7148251
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: December 12, 2006
    Assignee: The Regents of the University of Michigan
    Inventor: James A. Shayman
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20060217560
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: March 8, 2006
    Publication date: September 28, 2006
    Inventor: James Shayman
  • Methods and compositions for using aleveolar macrophage phospholipase A2
    Publication number: 20060008455
    Abstract: The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.
    Type: Application
    Filed: March 15, 2005
    Publication date: January 12, 2006
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James Shayman, Akira Abe, Miki Hiraoka
  • Methods and compositions for using aleveolar macrophage phospholipase A2
    Publication number: 20050281803
    Abstract: The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.
    Type: Application
    Filed: April 28, 2005
    Publication date: December 22, 2005
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James Shayman, Akira Abe, Miki Hiraoka
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20050267094
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 29, 2005
    Publication date: December 1, 2005
    Inventors: James Shayman, David Harris, Craig Siegel, Carol Nelson, Diane Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20050239862
    Abstract: Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: March 10, 2005
    Publication date: October 27, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: James Shayman, Norman Radin
  • Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Publication number: 20050222244
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: March 28, 2005
    Publication date: October 6, 2005
    Applicants: Genzyme Corporation, The Regents of the University of Michigan
    Inventors: Craig Siegel, James Shayman, Carol Nelson, David Harris, Diane Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6916802
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: July 12, 2005
    Assignees: Genzyme Corporation, The Regents of the University of Michigan
    Inventors: James A. Shayman, David J. Harris, Craig Siegel, Carol A. Nelson, Diane P. Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6890949
    Abstract: Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: May 10, 2005
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20050049235
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 3, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: James Shayman, Norman Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20040260099
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 15, 2004
    Publication date: December 23, 2004
    Applicant: The Regents of the University of Michigan
    Inventor: James A. Shayman
  • Compositions and methods for treating autoimmune disease
    Publication number: 20030119789
    Abstract: Methods and compositions are described for treating and diagnosing autoimmune diseases, and in particular for treating and detecting rheumatoid arthritis. Treatment is described with a new class of anti-RA drug, namely compounds that inhibit proliferation and induce apoptosis.
    Type: Application
    Filed: October 31, 2002
    Publication date: June 26, 2003
    Applicant: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, James A. Shayman, Shi-Yu Tan
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6569889
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: May 27, 2003
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20030073680
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 29, 2002
    Publication date: April 17, 2003
    Applicant: The Regents of The University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Compositions for treating autoimmune disease
    Patent number: 6518259
    Abstract: Methods and compositions are described for treating and diagnosing autoimmune diseases, and in particular for treating and detecting rheumatoid arthritis. Treatment is described with a new class of anti-RA drug, namely compounds that inhibit proliferation and induce apoptosis.
    Type: Grant
    Filed: May 22, 2000
    Date of Patent: February 11, 2003
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, James A. Shayman, Shi-Yu Tan
  • Amino ceramide - like compounds and therapeutic methods of use
    Publication number: 20020198240
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 29, 2002
    Publication date: December 26, 2002
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide - like compounds and therapeutic methods of use
    Publication number: 20020156107
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: January 10, 2002
    Publication date: October 24, 2002
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide - like compounds and therapeutic methods of use
    Publication number: 20010041735
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: May 31, 2001
    Publication date: November 15, 2001
    Inventors: James A. Shayman, Norman S. Radin