Patents by Inventor James A. Shayman

James A. Shayman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6255336
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: July 3, 2001
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Compositions and methods for treating autoimmune disease
    Patent number: 6098631
    Abstract: Methods and compositions are described for treating and diagnosing autoimmune diseases, and in particular for treating and detecting rheumatoid arthritis. Treatment is described with a new class of anti-RA drug, namely compounds that inhibit proliferation and induce apoptosis.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: August 8, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: Joseph Holoshitz, James A. Shayman, Shi-Yu Tan
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6051598
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: April 18, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6040332
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: March 21, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 6030995
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: October 29, 1998
    Date of Patent: February 29, 2000
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 5952370
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: September 14, 1999
    Assignee: The Regents of University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide-like compounds and therapeutic methods of use
    Patent number: 5945442
    Abstract: Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer sythase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: June 26, 1997
    Date of Patent: August 31, 1999
    Assignee: The Regents of The University of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Amino ceramide--like compounds and therapeutic methods of use
    Patent number: 5916911
    Abstract: Novel amino compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Grant
    Filed: September 5, 1996
    Date of Patent: June 29, 1999
    Assignee: The Regents Of The University Of Michigan
    Inventors: James A. Shayman, Norman S. Radin
  • Treatment of diabetic nephropathy
    Patent number: 5302609
    Abstract: The present invention is a novel method for the treatment of renal hypertrophy and hyperplasia associated with diabetic nephropathy. The method of the present invention generally comprises the administration to the diabetic patient of a compound which inhibits glycosphingolipid synthesis, more particularly, an inhibitor of GlcCer synthase or 3-ketodihydrosphingosine synthase.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: April 12, 1994
    Assignee: The Regents of the University of Michigan
    Inventors: James A. Shayman, Norman S. Radin