Abstract: The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.

Abstract: A grafted glycosaminoglycan polymer is disclosed. The grafted glycosaminoglycan polymer comprises a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.

Abstract: A server device, system, method, and for controlling access to project resources is disclosed. The disclosure includes a processor, and a communications module and a memory coupled to the processor. The memory, when executed by the processor, causes the processor to generate a plurality of zones for a project, each zone defining a set of access rights to: i) a database; and ii) at least one tool. The processor configures each set of access rights to allow a proxy service to access the zones, and receives, from a client device and via the proxy service, an access query to access at least one zone. The processor provides the client device access to, via the proxy service, the at least one dataset and at least one tool of the at least one zone.

Abstract: The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

Abstract: A ladder for a user to climb and which holds a rag includes a first rail having a top and a second rail and rungs attached to the first rail and second rail. The ladder includes an end cap that is attached adjacent to the top of the first rail. The end cap having an attachment portion which attaches to the first rail and a cover portion which covers over the first rail, and extend caps from the attachment portion. The cover portion having a rag holder. The ladder includes a pad attached to the back of the cover portion which contacts a surface against which the first rail leans down so as not to mar or scratch or damage the surface. An end cap. A method.

Abstract: A paintbrush and paint roller support rack and methods of using same. The paintbrush and paint roller support rack may include an upper support rack, a lower support rack, and vertical members extending between the lower support rack and the upper support rack, the vertical members supporting the upper support rack a distance above the lower support rack. The upper support rack may include inward extending upper horizontal support members spaced thereabout and the lower support rack may include inward extending lower horizontal members spaced thereabout, and the inward extending lower horizontal members may include one or more support pegs extending vertically upwards from the one or more of the lower horizontal members.

Abstract: Systems and methods for training machine learning models utilized for autonomous driving. An example method includes obtaining a set of data corresponding to the operation of a vehicle, wherein the set of data includes a first set of data corresponding to the operation of a vision-based detection system and a second set of data corresponding to the operation of a non-vision-based detection system, wherein the first and second set of data corresponding to a common timestamp; processing the first set of data to correspond to a common format for detection; processing the second set of data to correspond to the common format for detection; combining the processed first set of data and the processed second set of data to form a common set of data; processing the combined set of data; and training a machine learning model for vision-based detection system based on the processing combined set of data.

Abstract: Joining systems, clamping fixtures, and related systems and methods are generally described.

Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled form the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.

Abstract: An electrical-box-and-bracket that can include a bracket including a support body, with a bracket opening, and first and second support arms extending from the support body on opposing sides of the bracket opening. An electrical box can have a front opening and can be positioned within the bracket opening. The assembly can further include a set of adjustable fasteners, including first and second box adjustment fasteners and an adjustable far side support. The first and second box adjustment fasteners can extend through a rear wall of the electrical box and to the first and second support arms and can be accessible for selectively adjusting the distance between the bracket opening of the bracket and the front opening of the electrical box. The adjustable far side support can extend through the rear wall of the electrical box and can be accessible for adjustably supporting the electrical box.

Abstract: An electronic smoking article includes a liquid supply region including liquid material and a heater-wick element operable to wick liquid material and heat the liquid material to a temperature sufficient to vaporize the liquid material and form an aerosol. The heater-wick element comprises a plurality of fused metal beads or particles.

Abstract: The disclosed embodiments include computer-implemented processes that predict a credit score for a customer in real-time based on an application of a trained machine-learning or artificial-intelligence process to encrypted event data at a third-party computing cluster. For example, an apparatus may transmit encrypted event data to a third-party computing system. The third-party computing system may apply a trained artificial intelligence process to encrypted feature data that includes the encrypted event data, and the apparatus may receive, from the third-party computing system, encrypted output data representative of a predicted credit score during at least one temporal interval. The apparatus may decrypt the encrypted output data using a homomorphic decryption key, and transmit a notification that includes the decrypted output data to a device. An application program executed at the device may present a graphical representation of at least a portion of the decrypted output data within a digital interface.

Abstract: A method for forming a set of gun barrels, comprises: machining an elongate key along a length of a metal billet; mounting the metal billet on a machining jig, clamped along the key; performing CNC milling operations on the mounted metal billet in a 5-axis CNC milling machine to form a set of gun barrels having a pair of bores and a rib, the rib extending lengthwise proximate the elongate key; and, separating the set of gun barrels from the key along the length of the rib section. The present invention provides for significantly faster machine production with no manual handling of the workpiece throughout the milling operations. This makes the milling operations more accurate as the workpiece remains in position throughout, without reloading. Holding the workpiece along a key which runs the length of what will become the rib of the barrels avoids any loading of the workpiece in areas that need to be machined.

Abstract: Method and system for the extraction of oils from a biomass with a liquid carbon dioxide using cosolvent. The system and method can be used to extract cannabinoids from Cannabis biomass by cryogenically freezing the biomass and exposing the Cannabis biomass to sub-cooled liquid carbon dioxide and capturing a first high-terpene extract fraction, and then exposing the Cannabis biomass with a mixture of superfluid carbon dioxide and a cosolvent to capture a high cannabinoid second fraction.

Abstract: A grafted glycosaminoglycan polymer is disclosed. The grafted glycosaminoglycan polymer comprises a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.

Abstract: Systems and methods are provided for allowing users to safely and efficiently conduct repeatable dynamic experiments involving coordinated applications of force, motion, pressure, temperature, flow, dispersion and other physical events via a testing fixture positioned within an imaging environment.

Abstract: In some implementations, the disclosed systems and methods can capture visual frames and an object manager can recognize a visual signal within the captured visual frames, such as a QR code. In some implementations, the disclosed systems and methods can participate in a private conference within a session.

Abstract: A system is comprised of one or more processors coupled to memory. The one or more processors are configured to receive image data based on an image captured using a camera of a vehicle and to utilize the image data as a basis of an input to a trained machine learning model to at least in part identify a distance of an object from the vehicle. The trained machine learning model has been trained using a training image and a correlated output of an emitting distance sensor.

Abstract: A gap blocking system includes a loading platform having a gap separating a first portion of the loading platform from a second portion of the loading platform. A ride vehicle is coupled to a transport extending through the gap. A guardrail assembly having a plurality of guardrail units is coupled to the first portion, where the guardrail units are configured to transition between a first position and a second position. The guardrail units are configured to block access to the gap when in the first position. The ride vehicle includes an engagement feature configured to interface with an individual guardrail unit of the guardrail units to selectively transition the individual guardrail unit from the first position to the second position. The individual guardrail unit is configured to permit the ride vehicle to occupy a guest-accessible position adjacent to or on the loading platform in the second position.