Abstract: A sprung display case for dispensing products, particularly heavy products such as beverage multipacks. The case comprises a vertical chamber that is open at an upper end (and is sized and shaped such that a plurality of the products can be vertically stacked within the chamber; a horizontal platform that is mounted to be vertically slidable within the chamber, the platform having at least one air hole formed therethrough; a single resiliently compressible member mounted in the chamber between a lower side of the platform and an upper side of a base of the chamber to bias the platform towards the upper end of the chamber; and a tether fixed at a first end to the platform and at a second end to the base of the chamber to prevent the platform moving out of the upper end of the chamber.

Abstract: There is disclosed a nanopore support structure comprising a wall layer comprising walls defining a plurality of wells, and overhangs extending from the walls across each of the wells, the overhang defining an aperture configured to support a membrane suitable for insertion of a nanopore. There is further disclosed a nanopore sensing device comprising a nanopore support structure, and methods of manufacturing the nanopore support structure and the nanopore sensing device.

Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The invention relates to new methods of moving helicases past spacers on polynucleotides and controlling the loading of helicases on polynucleotides. The invention also relates to new methods of characterising target polynucleotides using helicases.

Abstract: Component weight and/or volume fractions of subterranean rock are determined. A formation model generates mineral and fluid concentration data from which elemental concentrations are calculated. Forward modeling produces a simulated energy spectrum, and simulation produces a simulated constraining log. Spectra is generated by detecting gamma radiation with a neutron logging tool, and a constraining log is generated. The spectrum and the simulated energy spectrum are compared with resultant error determined. The constraining log and simulated constraining log are compared with resultant error determined. The formation model generates further mineral and fluid concentration to calculate further elemental concentrations. Forward modeling produces further simulated energy spectrum signal and further constraining logs. The spectrum signals and further simulated spectrum signal are compared with resultant error determined.

Abstract: A gap blocking system includes a loading platform having a gap separating a first portion of the loading platform from a second portion of the loading platform. A ride vehicle is coupled to a transport extending through the gap. The gap blocking system also includes a panel assembly coupled to the loading platform and comprising a plurality of panels, wherein each panel of the plurality of panels is coupled to a respective biasing mechanism coupled to the first portion of the loading platform and configured to bias each panel towards a closed configuration in which each panel extends radially away from the first portion of the loading platform.

Abstract: The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

Abstract: A glycophospholipid polymer is disclosed. The glycophospholipid polymer comprises a reaction product of one or more glycosaminoglycans and one or more phospholipids. Also disclosed is a glycophospholipid polymeric network comprising a reaction product of one or more glycosaminoglycans, one or more phospholipids and, one or more crosslinking agents.

Abstract: Aspects of this disclosure relate to detecting power associated with an individual carrier of a carrier aggregated signal. In an embodiment, an aggregated carrier including at least a first carrier and a second carrier is provided. An indication of power of the first carrier of the aggregated carrier is detected. Separately from detecting the indication of power of the first carrier, an indication of power of the second carrier of the aggregated carrier is detected. The power associated with a radio frequency (RF) signal provided to an RF source associated with the first carrier can be adjusted based on the indication of power of the first carrier.

Abstract: A drive mechanism for a drug delivery device with a reduced operating loudness includes a dose selector, a housing, and a ratchet with a gear element comprising a plurality of gear teeth connected with the dose selector and a pawl element rotationally constrained to the housing comprising at least one pawl tooth. The at least one pawl tooth engages with the gear teeth and is located opposite to the gear teeth. One of the gear element and the pawl element moves forth and back relative to the other element of the gear and pawl elements along a first direction for de-engagement and re-engagement of the opposite gear teeth and at least one pawl tooth when the gear element rotates relative to the housing during dose setting using the dose selector. The pawl element and/or gear element comprises a noise reduction characteristic at a surface which dampens the noise produced.

Abstract: Circuits and methods related to radio-frequency (RF) architectures having carrier aggregation. In some implementations, a method for performing carrier aggregation (CA) can include providing a duplexer configured to provide duplexing functionality for a first frequency band and a second frequency band with a common antenna. The method can further include providing a first amplification path and a second amplification path coupled to respective ports of the duplexer, each of the first amplification path and the second amplification path configured to amplify a signal in its respective frequency band, each amplification path including a transmit/receive (TX/RX) switch configured to provide time-division duplexing (TDD) functionality for the amplified signal and a received signal. In some implementations, the first frequency band includes a B39 band, and the second frequency band includes a B41 band.

Abstract: Provided are formulations, methods, and devices for providing a hydrogel. The formulations and resulting hydrogels may be used for treating various disorders, including ocular disorders. In certain embodiments, the hydrogel is formed from formulations comprising (a) a nucleo-functional polymer that is a biocompatible polyalkylene polymer substituted by (i) a plurality of —OH groups, (ii) a plurality of thio-functional groups —R1—SH wherein R1 is an ester-containing linker, and (iii) optionally one or more —OC(O)—(C1-C6 alkyl) groups, such as a thiolated poly(vinyl alcohol) polymer; (b) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups; and (c) one or more pharmaceutically active agents. In certain embodiments, the hydrogel is formed at a targeted sited using methods and/or devices for focal administration of the formulations and/or hydrogels described herein.

Abstract: Droplet interfaces are formed between droplets in an electro-wetting device comprising an array of actuation electrodes. Actuation signals are applied to selected actuation electrodes to place the droplets into an energised state in which the shape of the droplets is modified compared to a shape of the droplets in a lower energy state and to bring the two droplets into proximity. The actuation signals are then changed to lower the energy of the droplets into the lower energy state so that the droplets relax into the gap and the two droplets contact each other thereby forming a droplet interface. The use of sensing electrodes in the device permit electrical current measurements across the droplet interface. The sensing electrodes can be used for either (i) applying a reference signal during droplet actuation or (ii) recording electrical current measurements.

Abstract: Disclosed herein is a method of alleviating symptoms of ocular surface discomfort, the method comprising: topically applying a cold slurry adjacent to a corneal limbus of an eye of a patient, wherein the cold slurry comprises water and a freezing point depressant, wherein the topical application of the cold slurry is configured to cause a degree of numbing of a cornea of the eye for a period of time, and wherein an ocular sensation of the eye is restored following the period of time.

Abstract: A computing device has an energy storage device system with multiple energy storage devices. Various different criteria are used to determine which one or more of the multiple energy storage devices to charge or discharge at any given time to provide power to the computing device. The criteria can include characteristics of the energy storage devices as well as hardware and/or physical characteristics of the computing device, characteristics of the energy storage devices and/or the computing device that change while the computing device operates, and predicted behavior or usage of the computing device. These criteria are evaluated during operation of the computing device, and the appropriate energy storage device(s) from which to draw power or to charge at any given time based on these criteria are determined.

Abstract: The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. The invention also concerns coupling a second analyte to the membrane and investigating the second analyte. The first analyte is uncoupled form the membrane prior to investigating the second analyte. The invention also relates to polynucleotide sequencing.

Abstract: This disclosure addresses an exercise device adapted to enable the user to perform a salmon ladder exercise. The ladder includes a frame with at least one pair of support protrusions that receive an exercise bar. A bearing surface that receives the shaft of a catch array rotatably mounted in the frame. The device further includes a braking mechanism that applies a variable suppression force to the catch array shaft, the variable suppression adjusting the force required to rotate the catch array shaft in the bearing surface.

Abstract: A fluid end includes a block, a suction bore formed in the block and having a suction valve disposed within the suction bore, and a discharge bore formed in the block and having a discharge valve disposed within the discharge bore. The fluid end also includes a plunger bore formed in the block and having a plunger disposed therein, the plunger moveable in a first direction and a second direction opposite the first direction such that the plunger draws fluid through the suction valve when the plunger moves in the first direction and forces fluid through the discharge valve when the plunger moves in a second direction. The fluid end further includes a seal pack configured to maintain sealing contact with the plunger as the plunger moves in the first direction or the second direction and a coating applied to the block between the seal pack and the block.

Abstract: An anaerobically curable composition comprising: a liquid anaerobically curable component; a solid anaerobically curable component; a solid thermoplastic polyurethane resin having a molecular weight in the range of from 40,000 g/mol to 100,000 g/mol and a melting point in the range of from 40° C. to 80° C.; and a curing component for curing the anaerobically curable components. Advantageously, the compositions of the invention are substantially solid and may be used as threadlockers.

Abstract: A sofa frame covered by a form fitting upholstery sack where the upholstery sack incorporates integrated support webbing comprising a plurality of webbing straps. With the upholstery sack properly positioned on the back rest portion, the support webbing is positioned on the front of the back rest portion frame. The upholstery sack is pre-formed to snugly fit over the back rest portion of the sofa frame. Installation time is decreased when compared to the time required for conventional webbing and upholstery installations.