Patents by Inventor James B. Doherty

James B. Doherty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienamycin derivatives as anti-inflammatory agents
    Patent number: 4465687
    Abstract: N-acyl-derivatives of thienamycin esters are found to be potent elastase inhibitors and therefore are useful anti-inflammatory agents.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: August 14, 1984
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Morris Zimmerman, Bonnie M. Ashe
  • Tricyclic derivatives of substituted pyrrole acids as analgesic and anti-inflammatory agents
    Patent number: 4440779
    Abstract: Tricyclic derivatives of substituted pyrrole acids, e.g., substituted 4,10-dihydro-10-oxo-1H-[1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: April 3, 1984
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Conrad P. Dorn, Bruce E. Witzel, Debra L. Allison, Tsung-Ying Shen
  • Nonsteroidal compounds as anti-inflammatory and analgesic agents
    Patent number: 4434175
    Abstract: 5-Aroyl-4-RO-, 5-aroyl-4-RS-, 5-aroyl-4-RSO-, 5-aroyl-4-RSO.sub.2 -, or 5-pyrrylcarbonyl-pyrrole alkanoic acid have been prepared via hydrolysis of a precursor-ester after high temperature decarboxylation or from direct acidic decarboxylation of a precursor diacid. The compounds are analgesic and anti-inflammatory agents of high activities but low ulcerogenic side effects.
    Type: Grant
    Filed: May 3, 1982
    Date of Patent: February 28, 1984
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Michael N. Chang, Conrad P. Dorn
  • Process for the preparation of zomepirac and related compounds
    Patent number: 4374997
    Abstract: Zomepirac and its analogs have been prepared from a 5-aroyl-3-hydroxycarbonyl-4-substituted pyrrole-2-acetic acid via acidic decarboxylation.
    Type: Grant
    Filed: June 4, 1981
    Date of Patent: February 22, 1983
    Assignee: Merck & Co., Inc.
    Inventors: James B. Doherty, Debra L. Allison
  • Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
    Patent number: 4368190
    Abstract: Immunologically active compounds of the formula: ##STR1## wherein: R.sub.1 is C.sub.1-7 alkyl; substituted C.sub.1-7 alkyl; phenyl; or substituted phenyl;R.sub.2 is hydrogen; C.sub.1-7 alkyl; substituted C.sub.1-7 alkyl; phenyl; substituted phenyl; phenyl C.sub.1-4 alkyl; or substituted phenyl C.sub.1-4 alkyl;R.sub.3 and R.sub.4 may be the same or different and are each independently hydrogen, provided that R.sub.3 and R.sub.4 may not both be hydrogen; or ##STR2## where X is --O--; --S--; or ##STR3## R.sub.10 is hydrogen; C.sub.1-30 alkyl; C.sub.2-30 alkenyl; C.sub.1-30 alkoxy; phenyl; C.sub.1-20 alkylsulfonyl; or cholesteryl;R.sub.11, R.sub.12, R.sub.13, R.sub.14, and R.sub.15 may be the same or different and are each independently hydrogen; C.sub.1-20 alkyl; C.sub.1-20 alkylcarbonyloxy; amino; benzyl; C.sub.1-20 alkoxymethyl; C.sub.1-20 alkylamido; or ##STR4## r is 0 or 1; s is 0 or 1; and t is 0 to 20; provided that s may only be 0 when both r and t are greater than 0 or when r is 0 and R.sub.
    Type: Grant
    Filed: April 17, 1980
    Date of Patent: January 11, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Philippe L. Durette, Conrad P. Dorn, Jr., James B. Doherty, Richard T. Dean