Abstract: A method of manufacturing a monolithic fiber-reinforced polymer composite component is provided. The method comprises providing a mould comprising a main cavity and at least one additional cavity that extends from the main cavity; introducing a polymer matrix material containing chopped fiber reinforcement into the mould to fill the main cavity and the at least one additional cavity to form a monolithic fiber-reinforced polymer composite component with a main portion formed in the main cavity and at least one raised feature formed in the additional cavity and extending from a surface plane of said main portion. The at least one raised feature is arranged to incur visually perceptible damage when the component is subject to an impact with an energy above a predetermined impact energy threshold and to resist an impact with an energy below the predetermined impact energy threshold.

Abstract: The present disclosure provides anti-tau antibodies and vectorization thereof (e.g., into AAV particles). Also provided are methods of using anti-tau antibodies and/or AAV particles for prevention, treatment, and/or diagnosis of neurological indications.

Abstract: A heating system is provided. The heating system comprises an induction heating assembly configured to generate a varying magnetic field and a heating target assembly comprising one or more heating targets, wherein the one or more heating targets are moveable relative to the induction heating assembly, the one or more heating targets being heatable by penetration with the varying magnetic field.

Abstract: A hair styling device for heating hair is provided. The device comprises an induction heating plate arranged to be heated by penetration with a varying magnetic field and an induction heating assembly configured to generate the varying magnetic field.

Abstract: The present specification provides an electric battery monitoring system. The system has particular application in electric vehicles where there it is desired to balance energy consumption to preserve vehicle range while also periodically monitoring for unsafe conditions that could lead to a thermal event.

Abstract: The present invention relates generally to the fields of medicine, immunology, and cancer biology. More particularly, it concerns antibodies that target HSP70 and methods of their use. Provided herein are agents such as antibodies that target HSP70. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of an HSP70-targeting agent such as an HSP70-specific antibody. The HSP70-specific antibody may enhance uptake of HSP70 by antigen presenting cells.

Abstract: Disclosed herein are novel small molecules that can be used therapeutically to treat ailments and diseases associated with an over-active or undesired immune response. Specific embodiments include inhibitors of Proteinase 3 (PR3) and Human Neutrophil Elastase (HNE) and methods for their synthesis and use. The agents can be used to treat alpha-1 antitrypsin deficiency and other ailments related to neutrophil activity.

Abstract: A storage tank includes a storage chamber configured to store a working fluid such as for example a cryogenic fluid. The storage tank has a first skin forming the storage chamber and a second skin positioned radially outwardly of the first skin. An insulation cavity is formed between the first skin and the second skin.

Abstract: A method of manufacturing a composite (e.g. fibre-reinforced polymer) connector comprises: manufacturing a tubular hub portion which extends substantially parallel to a central axis C, the hub portion comprising a thermoplastic polymer reinforced with continuous, circumferentially-oriented fibre reinforcement; placing the hub portion into a mould featuring at least one cavity; and introducing polymer into the mould so as to fill the at least one cavity to form a flange portion around the hub portion.

Abstract: A fiber-reinforced polymer composite component formed from a polymer matrix material containing fiber reinforcement. The component comprises a main portion and at least one raised feature extending from a surface plane s of said main portion. The at least one raised feature is arranged to incur visually perceptible damage when the component is subject to an impact with an energy above a predetermined impact energy threshold and to resist an impact with an energy below the predetermined impact energy threshold.

Abstract: A heating system is provided. The heating system comprises an induction heating assembly configured to generate varying magnetic fields, a heating target assembly comprising a plurality of heating targets, the plurality of heating targets being heatable by penetration with a varying magnetic field. A first subset of the plurality of heating targets has a first resonant heating characteristic and a second subset of the plurality of heating targets has a second resonant heating characteristic, and the first and second resonant heating characteristics are different. The system further comprises a controller configured to: control the induction heating assembly based on the first resonant heating characteristic to generate a first varying magnetic field to heat the first subset and control the induction heating assembly based on the second resonant heating characteristic to generate a second varying magnetic field to heat the second subset.

Abstract: A process and a process plant for conversion of SO2 to H2SO4 including a. directing a process gas stream including at least 15 vol % SO2, and an amount of O2 originating from a source of purified O2 or O2 enriched air to contact a first material catalytically active in oxidation of SO2 to SO3 under oxidation conditions involving a maximum steady state temperature of the catalytically active material above 700° C., to provide an oxidized process gas stream, wherein the material catalytically active in oxidation of SO2 to SO3 includes an active phase in which the weight ration of vanadium to other metals is at least 2:1 supported on a porous carrier comprising at least 25 wt % crystalline silica, b. absorbing at least an amount of the produced SO3 in a stream of lean sulfuric acid to provide a stream of liquid sulfuric acid.

Abstract: An electric motor is provided that includes a rotor, a stator, and a filter. The stator includes a stator core and windings. The filter is a magnetic low-pass filter including a coil having one or more turns and one or more capacitors connected in series with the coil. Excitation of the windings generates stator flux, the coil is linked to the stator flux, and the filter attenuates harmonics in the stator flux.

Abstract: A composite shaft with an end fitting mounted on an interface region on at least one end of said shaft, and a preload structure arranged to provide a biasing force to bias the composite shaft against the end fitting; wherein the preload structure is in an interference fit with the composite shaft. The preload structure is applied to the composite shaft in a subsequent operation to the mounting of the end fitting to the shaft.

Abstract: The present disclosure provides anti-tau antibodies and vectorization thereof (e.g., into AAV particles). Also provided are methods of using anti-tau antibodies and/or AAV particles for prevention, treatment, and/or diagnosis of neurological indications.

Abstract: This invention is an apparatus to produce electrical power from the wearer's respiration through the application of a circular cluster of Variable Reluctance sensors that are excited by a rotating disk holding a plurality of magnets arranged radially, on its face, and spaced uniformly about its circumference. The sensors' arrangement conforms to the circumference and are perpendicular to the face of the rotating disk. This arrangement produces corresponding sinusoidal voltages that are each converted to DC via a corresponding rectifier circuit. The resulting DC voltage outputs are then summed to produce a single power output, which is fed to a DC-to-DC converter. The rotating disk's unidirectional motion is produced by a ratchet gear system attached to a partially elastic torso garment, which is worn on the mid torso. The ratchet gear system moves proportionally, in response to the reciprocal motion of a wearer's respiration.

Abstract: This invention is an apparatus to produce electrical power from the wearer's respiration through the application of a circular cluster of Variable Reluctance sensors that are excited by a rotating disk holding a plurality of magnets arranged radially, on its face, and spaced uniformly about its circumference. The sensors' arrangement conforms to the circumference and are perpendicular to the face of the rotating disk. This arrangement produces corresponding sinusoidal voltages that are each converted to DC via a corresponding rectifier circuit. The resulting DC voltage outputs are then summed to produce a single power output, which is fed to a DC-to-DC converter. The rotating disk's unidirectional motion is produced by a ratchet gear system attached to a partially elastic torso garment, which is worn on the mid torso. The ratchet gear system moves proportionally, in response to the reciprocal motion of a wearer's respiration.

Abstract: This invention is an apparatus to produce electrical power from the wearer's respiration through the application of a circular cluster of Variable Reluctance sensors that are excited by a rotating disk holding a plurality of magnets arranged radially, on its face, and spaced uniformly about its circumference. The sensors' arrangement conforms to the circumference and are perpendicular to the face of the rotating disk. This arrangement produces corresponding sinusoidal voltages that are each converted to DC via a corresponding rectifier circuit. The resulting DC voltage outputs are then summed to produce a single power output, which is fed to a DC-to-DC converter. The rotating disk's unidirectional motion is produced by a ratchet gear system attached to a partially elastic torso garment, which is worn on the mid torso. The ratchet gear system moves proportionally, in response to the reciprocal motion of a wearer's respiration.

Abstract: The invention features compounds which modulate FGF activity, e.g., by enhancing the binding between FGF-2 and its receptors, e.g., FGF-R1. Also featured is a pharmaceutical composition containing one or more of the compounds, a method of treating an injury or a disease e.g., stroke, congenital hypogonadotropic hypogonadism, and viral infection, and a method of increasing spermatogenesis using the pharmaceutical composition.

Abstract: A method of manufacturing a connector for a fluid transfer conduit comprises: manufacturing a tube which runs parallel to a central axis C from fibre-reinforced polymer, said tube comprising a hub portion 206 and a flange-forming portion 208 located adjacent to the hub portion 206, wherein the hub portion 206 comprises continuous circumferentially oriented fibre-reinforcement 210; and the hub portion 206 and the flange-forming portion 208 comprise longitudinally oriented fibre-reinforcement 212 which runs continuously from the hub portion 206 into the flange-forming portion 208; and bending the flange-forming portion 208 away from the central axis C such that it extends from the hub portion 206 at an angle to the central axis C.