Abstract: A composite structural component made of a polymer matrix composite material includes an end connection that includes an end portion at one end of the composite structural component, comprising an internal surface comprising a plurality of ridges and grooves defining a first engagement surface along an axial direction and a metal interface component comprising an outer surface comprising a plurality of ridges and grooves defining a second engagement surface along the axial direction and an inner surface defining a mounting surface for attachment of an end fitting. The metal interface component is engaged with the internal surface of the composite structural component by mating of the first and second engagement surfaces. The structure also includes an outer annular component fitted around the end portion in axial alignment with the mating of the first and second engagement surfaces.

Abstract: A composite shaft with an end fitting mounted on an interface region on at least one end of said shaft, and a preload structure arranged to provide a biasing force to bias the composite shaft against the end fitting; wherein the preload structure is in an interference fit with the composite shaft. The preload structure is applied to the composite shaft in a subsequent operation to the mounting of the end fitting to the shaft.

Abstract: A pressure vessel includes front and rear end plates and a plurality of open-ended vessel structures constructed of fibre-reinforced polymer matrix composite material positioned adjacent to one another so that their longitudinal axes are parallel to a longitudinal direction extending between the front and rear end plates. The vessel also includes an outer reinforcement comprising polymer matrix composite material with continuous fibres extending longitudinally around the pressure vessel to secure the front and rear end plates to the vessel structures. At least one of the vessel structures has a partially curved cross section in a plane perpendicular to its longitudinal axis, such that one or more crevices are formed between the vessel structures, running longitudinally between the front and rear end plates and the front and rear end plates are shaped to allow the outer reinforcement to at least partially fill the one or more crevices between the vessel structures.

Abstract: The present disclosure describes composite actuator piston rods and methods for making such rods. Composite actuator piston rods of the present disclosure may include a composite actuator rod tube having a flared end, an insert, wherein the insert has a complementary shape to the flared end, a piston head concentrically surrounding the flared end of the composite actuator rod tube, and a piston head nut configured to threadingly attach to the piston head.

Abstract: An electrode array with a flexible array substrate on which plural spaced apart electrodes are disposed. Integrated circuits are disposed in the array substrate. The integrated circuits are mounted to package substrates. The package substrates are more rigid than the array substrate. Internal to each package substrate is at least one electrical conductor. The electrical conductor extends from a bond pad integral with integrated circuit at least partially through the package substrate. The electrical conductor functions as the conductive member that extends between the integrated circuit an electrode with which the integrated circuit is associated.

Abstract: The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R1, R4, R5, R6, and L1 are as defined herein. Compounds of formula (IA) have been found useful as EP4 receptor agonists useful in the treatment of glaucoma, osteoporosis, neuropathic pain, and related disorders.

Abstract: A method of forming an implantable electrode array that includes one or more packaged control modules. A control module is packaged by mounting the module to a substrate and forming a containment ring around the module. A conformal coating is disposed over the surface of the module to cover the carrier. Within the containment ring, the conformal coating hardens to form a non-porous shell around the control module. The one or more packaged control modules are placed in a flexible array. Electrodes that are mounted to or embedded in the flexible carrier are connected to the one or more control modules.

Abstract: The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R1, R4, R5, R6, and L1 are as defined herein. Compounds of formula (IA) have been found useful as EP4 receptor agonists useful in the treatment of glaucoma, osteoporosis, neuropathic pain, and related disorders.

Abstract: A host server is configured to receive information related to metrics and configurations associated with computer resources of a computer infrastructure, derive and resolve the information into capacity, performance, reliability, and efficiency, as related to attributes associated with the computer resources, including compute attributes such as application, virtual machine (VM) attributes, storage attributes, and network attributes. The host server provides the metrics and attributes in a matrix configuration as a graphical user interface (GUI) on an output device, such as a display. The GUI is configured to provide a user with a single point of view into the computer infrastructure by converging application, compute, storage, and network attributes into capacity, performance, reliability, and efficiency concepts. With such a configuration, the GUI allows the end user to readily review the environments for potential issues in a time efficient manner, as well as solutions provided by the GUI.

Abstract: An arrangement for landing gear comprises a piston, a bogie beam and forward and rear brake rods. The piston has an attachment portion with a pivot connection for the bogie beam at its lower end. The bogie beam is mounted to the attachment portion at the pivot connection. The bogie beam supports forward and rear brake assemblies on forward and rear sides of the piston. The forward brake rod is connected to the forward brake assembly at a location for acting under tension during braking and the rear brake rod is connected to the rear brake assembly at a location for acting under tension during braking. The rear end of the forward brake rod is connected to the attachment portion forward of the pivot connection of the bogie beam, and a forward end of the rear brake rod is connected to the attachment portion.

Abstract: A method of forming an implantable electrode array that includes one or more packaged control modules. A control module is packaged by mounting the module to a substrate and forming a containment ring around the module. A conformal coating is disposed over the surface of the module to cover the carrier. Within the containment ring, the conformal coating hardens to form a non-porous shell around the control module. The one or more packaged control modules are placed in a flexible array. Electrodes that are mounted to or embedded in the flexible carrier are connected to the one or more control modules.

Abstract: An implantable electrode array that includes a carrier on which multiple spaced apart electrodes are disposed. Embedded in the module are control modules. The control modules are contained in packages. Portions of the packages extend outwardly from the carrier so as to be disposed against adjacent surfaces of the carrier. The packages contain conductive tracts that provide conductive links from the conductors internal to the carrier to the packaged control modules.

Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: A method of fabricating coffee pods at a point of sale location using a coffee pod dispensing device with shell less, expandable coffee pods. The fabrication is initiated by tactile input from a control panel that determines the parameters of the coffee pods to be fabricated and generates the operational signals for the dispensing device. Fabrication there after progresses sequentially through a series of operations that involves the loading of the coffee pods onto a pod advancing means which then takes the coffee pods through the steps of expansion, filling, sealing and delivery. To accomplish this the pods are compressible pods arranged in a linear array that allows for pleated or stacked storage in a pod loading means within the device's enclosure, as well as continuous feed capabilities.

Abstract: A shell less, biodegradable coffee pod for use with a point of sale coffee pod dispensing device. The pod is compressible for pleated or stacked storage and linearly linked to a series of substantially similar pods by a flexible, hingeable separable tab bridging between adjacent pods. The pods have a support structure that is affixed to a fillable well. Each well is expandable with an expanding means (utilizing a burst of air, a vacuum or mechanical pusher) as the series of pods is mechanically advanced along a tractor feed style conveyor belt that passes the pod to a ground coffee bean filling unit, a sealing unit and a pod separating unit.

Abstract: A point of sale coffee pod dispensing device for use with shell less, expandable coffee pods. The compressible pods are arranged in a linear array that allows for pleated or stacked storage in a pod loading means within the device's enclosure, as well as continuous feed capabilities. The pod advancing means moves the pods from a pod loading station to the pod delivery station, there between sequentially passing through stations for pod expanding, coffee filling, and sealing. An operating system allows input of signals for the operation of the device based on tactile input from a control panel on the device's housing that determines the parameters of the coffee pods to be fabricated.

Abstract: A composite tubular structure is described suitable for transmitting axial loads in compression or tension. It comprises an elongate composite member 70 having a nut 50 retained in each end for forming a connection with another component. The composite member further comprises an inwardly tapered section at each end, each of which has an inner surface that follows a tapered outer surface of one of the embedded nuts. The inwardly tapered section narrows the composite member in a longitudinal direction towards one end so as to provide a constriction which retains the respective nut within. A connector 80, 84, 86 may clamp the end with a pre-load. A liner 60 may be used to support the nuts during deposition of the filaments in order to form the two inwardly tapered sections at the ends. It can allow the wall of the structure to be formed with different profiles.

Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.

Abstract: Disclosed herein are compounds of formula (I) wherein L1, L2, L3, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.

Abstract: Apparatus suitable for pilates and other exercise comprises rails, supported on a box-like frame and an exercise carriage, mounted on the rails, wherein the carriage comprises a first carriage section and a second carriage section which sections can be (i) connected together to form a single exercise carriage which slides forwards and backwards on the rails, or (ii) disconnected to form two exercise carriages which independently slide forwards and backwards on the rails. The apparatus also has a seat with a spring-biased foot pedal and a spring-biased trapeze bar.