Abstract: The present invention relates to modified forms of C-peptide, and methods for their use. In one aspect, the modified forms of C-peptide comprise PEGylated C-peptide derivatives comprising at least one PEG group attached to the N-terminus, which exhibit superior pharmacokinetic and biological activity in vivo.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

Abstract: The invention provides preferred dosage ranges, maximum concentrations, average concentrations and monitoring regimes for use in treatment of Alzheimer's disease using antibodies to A?. The invention also provides monitoring regimes that as can assess changes in symptoms or signs of the patient following treatment.

Abstract: The present invention provides improved methods and kits for treating the long-term complication of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits, can also maintain good glycemic control, and avoid excessive weight gain that may otherwise be associated with excessive insulin administration or caloric intake during C-peptide therapy.

Abstract: Improved methods and kits for treating the long-term complication of diabetes that reduce the risk of the patient developing hypoglycemia during C-peptide therapy. The use of such methods and kits, can also maintain good glycemic control, and avoid excessive weight gain that may otherwise be associated with excessive insulin administration or caloric intake during C-peptide therapy.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

Abstract: The invention provides preferred dosage ranges, maximum concentrations, average concentrations and monitoring regimes for use in treatment of Alzheimer's disease using antibodies to A?. The invention also provides monitoring regimes that can assess changes in symptoms or signs of the patient following treatment.

Abstract: A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which maintain fixed volumes and which may be used on patients of variable weight.

Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.

Abstract: An infra-red emitting decoy flare comprising a rupturable container 13 housing combustible flakes 1 and ignition means 20 for igniting the combustible flakes 1. Each of the combustible flakes 1 comprises a fibrous, carbon containing substrate on to which has been vapor deposited on one or both faces thereof a combustible material layer which is capable, in use, of igniting substantially simultaneously the entire surface onto which it is deposited.

Abstract: An infra-red emitting decoy flare capable of diverting an incoming missile equipped with a counter-countermeasures system away from an intended target consisting of a primer flare (2), a spectral flare (4) and a means for igniting the primer flare (22, 30), all contained within a flare casing (6). The primer flare (2) is formed from a fast burning pyrotechnic composition and is adapted to produce an intense infra-red source of short duration on ignition. The spectral flare (4) is ignited by the burning of the primer flare (2) and is adapted to produce a slower burning composition having a fixed ratio in the intensity of infra-red radiation emitted, when burning, in at least two fixed bands.

Abstract: A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody, polysorbate 80, a buffer which inhibits polysorbate oxidation is described along with methods of making the preparation. Also described are formulations with high antibody concentrations which maintain fixed volumes and which may be used on patients of variable weight.

Abstract: An infrared emitting pyrotechnic material comprising a fibrous carbon containing substrate (1) onto one or both faces (4, 5) of which is vapor deposited a combustible material layer (2, 3) which may be protected by an additional coating (6, 7). The thickness and composition of each of the layers (2, 3) are selected such that in use each of the layers is capable of igniting substantially simultaneously the entire surface on which it is deposited.

Abstract: In an intravenous needle and needle holder assembly, the needle is attached to an inner case, through which intravenous fluid is supplied, by a length of flexible tubing. An outer case is provided which surrounds the tubing during insertion of the needle into a patient's vein, so as to rigidify the needle during such insertion. After insertion, the outer case can be removed from at least a part of the flexible tubing so that the tubing provides a flexible connection between the inner case and the needle useful during administration of intravenous fluid.