Patents by Inventor James Clayton

James Clayton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190307393
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for measuring spectral information corresponding with propionic acid (PA), either alone or in combination with other measurements corresponding with other chemicals, to diagnose and/or monitor at least one of bacterial infection, such as associated with P. acnes, or conditions related thereto such as nociceptive pain associated with tissue acidity. An interfacing DDD-MRS signal processor receives output signals to produce a post-processed spectrum, with spectral regions corresponding with certain chemicals, including PA, then measured as biomarkers. A diagnostic processor derives a diagnostic value for each disc, and performs certain normalizations, based upon ratios of the spectral regions related to chemicals implicated in degenerative painful tissue pathology, such as PA and hypoxia markers of lactic acid (LA) and alanine (AL), and structural chemicals of proteoglycan (PG) and collagen or carbohydrate (CA).
    Type: Application
    Filed: December 18, 2018
    Publication date: October 10, 2019
    Inventors: Jeffrey C. Lotz, James Clayton Peacock, III, David S. Bradford, Stefan Dudli, Sergey G. Magnitsky
  • Patent number: 10343198
    Abstract: An impoundment closure system that employs a low permeability membrane on top of a waste materials with ponded water on top of the low permeability membrane.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: July 9, 2019
    Assignees: Commercial Liability Partners, LLC, Key Environmental, Inc.
    Inventors: Ron Froh, Alan E. Briggs, James Clayton
  • Publication number: 20190175051
    Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.
    Type: Application
    Filed: August 10, 2018
    Publication date: June 13, 2019
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
  • Publication number: 20190157234
    Abstract: A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source.
    Type: Application
    Filed: January 18, 2019
    Publication date: May 23, 2019
    Applicant: Immunolight, LLC.
    Inventors: Zakaryae FATHI, James Clayton, Harold Walder, Frederic A. Bourke, JR.
  • Publication number: 20190143144
    Abstract: Embodiments of the present invention describe systems and methods for providing radiotherapy treatment by focusing an electron beam on a target (e.g., a tungsten plate) to produce a high-yield x-ray output with improved field shaping. A modified electron beam spatial distribution is employed to scan the target, such as a 2D periodic beam path, which advantageously lowers the x-ray target temperature compared to the typical compact beam spatial distribution. As a result, the x-ray target can produce a high yield output without sacrificing the x-ray target life span. The use of a 2D periodic beam path allows a much colder target functioning regime such that more dosage can be applied in a short period of time compared to existing techniques.
    Type: Application
    Filed: November 16, 2018
    Publication date: May 16, 2019
    Inventors: Anuj PURWAR, Dragos CONSTANTIN, James CLAYTON
  • Patent number: 10285622
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: May 14, 2019
    Assignees: Nocimed, Inc., The Regents of the University of California
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Jeffrey C. Lotz
  • Patent number: 10283476
    Abstract: A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: May 7, 2019
    Assignee: IMMUNOLIGHT, LLC.
    Inventors: Zakaryae Fathi, James Clayton, Harold Walder, Frederic A. Bourke, Jr.
  • Patent number: 10251578
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: April 9, 2019
    Assignees: NOCIMED, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Jeffrey C. Lotz
  • Publication number: 20180358327
    Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
    Type: Application
    Filed: August 14, 2018
    Publication date: December 13, 2018
    Applicant: IMMUNOLIGHT, LLC.
    Inventors: Zakaryae FATHI, James Clayton, Harold Walder, Frederic A. Bourke, JR.
  • Publication number: 20180339322
    Abstract: An impoundment closure system that employs a low permeability membrane on top of a waste materials with ponded water on top of the low permeability membrane.
    Type: Application
    Filed: July 23, 2018
    Publication date: November 29, 2018
    Inventors: Ron FROH, Alan E. BRIGGS, James CLAYTON
  • Publication number: 20180269174
    Abstract: A curable resin or adhesive composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and at least one energy converting material, preferably a phosphor, capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 20, 2018
    Applicant: Immunolight, LLC
    Inventors: Zakaryae FATHI, James CLAYTON, Harold WALDER, Frederic A. BOURKE, JR.
  • Patent number: 10074627
    Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: September 11, 2018
    Assignee: Immunolight, LLC
    Inventors: Zakaryae Fathi, James Clayton, Harold Walder, Frederic A. Bourke, Jr.
  • Patent number: 10058904
    Abstract: An impoundment closure system that employs a low permeability membrane on top of a waste materials with ponded water on top of the low permeability membrane.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: August 28, 2018
    Assignees: Commercial Liability Partners, LLC, Key Environmental, Inc.
    Inventors: Ron Froh, Alan E. Briggs, James Clayton
  • Patent number: 10045711
    Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: August 14, 2018
    Assignee: NociMed, Inc.
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Ricardo Dario Pradenas
  • Patent number: 10026711
    Abstract: A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 17, 2018
    Assignee: Immunolight, LLC
    Inventors: Zakaryae Fathi, James Clayton, Harold Walder, Frederic A. Bourke, Jr.
  • Patent number: 10022565
    Abstract: A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: July 17, 2018
    Assignee: Varian Medical Systems, Inc.
    Inventors: Stavros Prionas, Michael C. Green, Edward Seppi, Larry D. Partain, James Clayton, Stanley Mansfield, John Boone
  • Patent number: 10024646
    Abstract: A method of determining a depth of a hole formed in a work piece is disclosed. The method includes determining the hole depth based upon a load signal indicative of a load on a tool forming the hole during the forming of the hole. The hole depth determined is then adjusted with an offset and component specifications are combined with the hole length to determine a component specification for use in the hole to fix components together. At least a part of the depth determination and component specification can be carried out automatically in a computer, for an array of holes.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: July 17, 2018
    Assignee: AIRBUS OPERATIONS LIMITED
    Inventors: Greg Andrew Hale, Gareth William Landeg, Matthew Lee Godfrey, Richard James Clayton, David John Hall
  • Publication number: 20180177428
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs.
    Type: Application
    Filed: August 17, 2017
    Publication date: June 28, 2018
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Jeffrey C. Lotz
  • Patent number: 9939550
    Abstract: In accordance with embodiments of the invention, at least the potential presence of Special Nuclear Material (“SNM”) is determined by the detection of prompt neutrons, prompt gamma rays, delayed neutrons, and/or delayed gamma rays from photofission, via time-of-flight (“TOF”) spectroscopic methods. Methods and systems are disclosed.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 10, 2018
    Assignee: VAREX IMAGING CORPORATION
    Inventors: James Clayton, Edward J. Seppi
  • Publication number: 20180055405
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing and diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra for multiple chemicals that have been correlated to painful vs. non-painful discs. A display provides an indication of results for analyzed discs as an overlay onto a MRI image of the lumbar spine.
    Type: Application
    Filed: August 4, 2017
    Publication date: March 1, 2018
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Jeffrey C. Lotz