Patents by Inventor James Collins

James Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECA INHIBITORS WITH ANTIBIOTIC ACTIVITY, COMPOSITIONS AND METHODS OF USE
    Publication number: 20100029597
    Abstract: The present invention is directed to the use of RecA inhibitors as antibiotic agents, and provides RecA inhibitors useful in treating infections. Also provided are various compositions and methods associated with RecA inhibition.
    Type: Application
    Filed: February 13, 2007
    Publication date: February 4, 2010
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, PURETECH VENTURES
    Inventors: Guillaume Cottarel, Jamey Wierzbowski, Kollol Pal, Michael Kohanski, Daniel Dwyer, James Collins, Michael Almstetter, Michael Thormann, Andreas Treml
  • Hand tools
    Patent number: 7640667
    Abstract: A pruner has a movable handle/blade assembly pivotally coupled to a static handle/blade assembly by a pivot assembly carried by the static handle. The pivot assembly further has a bush within the static handle and on which the movable handle/blade assembly is pivotally mounted, a spring for pivotally biasing the movable handle/blade assembly to an open position being retained by the pivot assembly within the static handle. Both the movable blade and static blade are mounted on the bush and are clamped laterally between two separate parts of the bush which are assembled together in screw threaded engagement, and the two blades are supported from the bush by a bearing ring of low friction material.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: January 5, 2010
    Assignee: ITW Australia Pty Ltd
    Inventors: Nathan Pollock, James Collins, Lee Rodezno, Peter Williams
  • COMPOSITIONS AND METHODS FOR ANTIBIOTIC POTENTIATION AND DRUG DISCOVERY
    Publication number: 20090264342
    Abstract: The present invention provides methods for identifying target genes whose partial or complete functional inactivation potentiates the activity of an antibiotic agent, e.g., a quinolone antibiotic. The invention further provides methods for identifying agents that modulate expression of target genes or that modulate activity of expression products of target genes. Agents identified according to various methods of the invention potentiate the activity of antibiotics such as quinolones, aminoglycosides, peptide antibiotics and ?-lactams. Also provided are agents that suppress and/or retard resistance to antibiotics. The inventive methods provide potentiating agents and compositions comprising potentiating agents and antibiotics. Such agents and compositions can be used for inhibiting growth or survival of a microbial cell or of treating a subject suffering from or susceptible to a microbial infection.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 22, 2009
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, PURETECH VENTURES
    Inventors: Guillaume Cottarel, Jamey Wierzbowski, Kollol Pal, Michael Kohanski, Daniel Dwyer, James Collins, Michael Almstetter, Michael Thormann, Andreas Treml
  • Influenza virus neuraminidase crystal structure and their use thereof
    Publication number: 20090265114
    Abstract: The invention relates to crystals of the influenza virus neuraminidase protein, their structures and their use.
    Type: Application
    Filed: June 6, 2007
    Publication date: October 22, 2009
    Inventors: Steven John Gamblin, Alan James Hay, John James Skehel, Lesley Findlay Haire, David John Stevens, Rupert Russell, Patrick James Collins, Yi Pu Lin, George Michael Blackburn
  • MIXED CELLULOSE ESTER FILMS HAVING +C PLATE AND -A PLATE OPTICAL PROPERTIES
    Publication number: 20090181232
    Abstract: The present invention relates to films made from mixed cellulose esters having low hydroxyl content and certain plasticizers. These films can exhibit +C plate, ?A plate, and biaxial Nz behavior, which make them particularly suitable for use in optical applications, such as in liquid crystal displays (LCD) as protective and compensator films.
    Type: Application
    Filed: February 26, 2009
    Publication date: July 16, 2009
    Applicant: Eastman Chemical Company
    Inventors: Bin Wang, Michael Eugene Donelson, Marcus David Shelby, James Collins Maine
  • UV ABSORBING ADDITIVES SUITABLE FOR THERMOPLASTIC ARTICLES MADE FROM PROCESSES WITH EXTENDED HEAT HISTORIES
    Publication number: 20090105380
    Abstract: A UV-protected, laminated article obtained by a thermocompressive lamination process. The laminated article is characterized by reduced haze due to the use of a benzotriazine UV absorber. A process for making such a laminated article and a method for preventing or inhibiting haze from developing in a UV-protected laminated article during application of heat and pressure are also described.
    Type: Application
    Filed: October 22, 2007
    Publication date: April 23, 2009
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Ryan Thomas Neill, Gary Wayne Hartley, Michael Eugene Donelson, James Collins Maine, Douglas Stephens McWilliams, Adia Marie Delaney-Jackson, Deanna Lynn Pickel
  • Gamma-secretase inhibitors
    Patent number: 7514459
    Abstract: Compounds of formula I: are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of ?-amyloid.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: April 7, 2009
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Ian James Collins, Joanne Clare Hannam, Andrew Madin, Mark Peter Ridgill
  • Method and Apparatus to Facilitate Depicting an Object in Combination with an Accessory
    Publication number: 20090033667
    Abstract: At a personally portable wireless two-way communicator (800), one can provide (101) an avatar as corresponds to a given object and then capture (102) an image as corresponds to an accessory for that given object. That image can be used (103) to determine corresponding metadata for the accessory which metadata is then used (104) to determine a virtual visual rendering of the accessory. One can then visually display (105) the avatar in combination with the virtual visual rendering of the accessory to thereby provide an image that depicts how the given object and the accessory will appear in combination with one another.
    Type: Application
    Filed: August 2, 2007
    Publication date: February 5, 2009
    Applicant: Motorola, Inc.
    Inventors: Shuang Xu, Timothy James Collins
  • Using branched polymers to control the dimensional stability of articles in the lamination process
    Publication number: 20090017320
    Abstract: Disclosed are laminated articles comprising a first polymer layer and a second polymer layer having an inclusion embedded between the layers, wherein at least one layer comprises a branching agent to improve dimensional stability during the lamination process. Disclosed are laminated articles comprising a first polymer layer and a second polymer layer having an inclusion embedded between the layers, wherein at least one layer comprises a copolyester comprising a branching agent to improve dimensional stability during the lamination process. Also disclosed are methods of laminating a first layer and a second layer with an inclusion between the layers to form a laminated article with an embedded inclusion, wherein at least one layer comprises a copolyester comprising a branching agent.
    Type: Application
    Filed: July 13, 2007
    Publication date: January 15, 2009
    Inventors: Michael Eugene Donelson, Ryan Thomas Neill, James Collins Maine, Bryan Steven Bishop, Robert Erik Young
  • Gamma-secretase inhibitors
    Patent number: 7435748
    Abstract: Compounds of formula I: inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: October 14, 2008
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Jose Luis Castro Pineiro, Ian James Collins, Timothy Harrison
  • INSERTION DEVICE FOR AN INSERTION HEAD, IN PARTICULAR FOR AN INFUSION SET
    Publication number: 20080249472
    Abstract: An insertion device for an infusion set, the insertion device including a two-part housing and a retainer or a retention means by which the infusion set can be temporarily held on the device, and a driver or a drive means including a pretensionable spring for providing the drive energy for an insertion movement of the infusion set, wherein one of the housing parts can be pivoted relative to the other to engage the infusion set and, after engagement of the infusion set, they can be pivoted again, as a result of which the spring is pretensioned and the insertion device is brought to a ready-to-use state. After the insertion movement has been triggered, the infusion set is separated from the device, such that it can execute the greatest part of the insertion movement free of the retainer.
    Type: Application
    Filed: March 13, 2008
    Publication date: October 9, 2008
    Applicant: Diesetronic Licensing AG
    Inventors: Jurg Liniger, Pascal Rutti, James Collins
  • Cyclic sulfamides for inhibition of gamma-secretase
    Patent number: 7427621
    Abstract: Compounds of formula I: inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: September 23, 2008
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian James Collins, Joanne Clare Hannam, Timothy Harrison, Andrew Madin, Mark Peter Ridgill
  • Method of use for a commercially available portable virtual reality system
    Publication number: 20080125218
    Abstract: The present invention comprises a method of use for a commercially available portable virtual reality device comprising use of a portable virtual reality device for entertainment by one or more persons who are in a mentally and physically sedentary setting; and use of a virtual reality scenario that is related to but more stimulating than a person's physical setting.
    Type: Application
    Filed: September 20, 2006
    Publication date: May 29, 2008
    Inventor: Kelly James Collins
  • Sulphonamido-substituted bridged bicycloalkyl derivatives
    Patent number: 7365196
    Abstract: A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: April 29, 2008
    Assignees: Merck Sharp & Dohme Ltd., Merck Frosst Canada & Co.
    Inventors: Patrice Charles Belanger, Ian James Collins, Joanne Claire Hannam, Timothy Harrison, Stephen John Lewis, Andrew Madin, Edward Giles McIver, Alan John Nadin, Joseph George Neduvelil, Mark Steven Shearman, Adrian Leonard Smith, Timothy Jason Sparey, Graeme Irvine Stevenson, Martin Richard Teall
  • Encapsulation of electrically energized articles
    Publication number: 20080085390
    Abstract: In one aspect the present invention relates to a method of making an encapsulated electrically energized device, the method comprising: providing a first layer and a second layer each independently comprising a copolyester, providing the electrically energized between the first and second layer, thermocompressively fusing the first layer and the second layer to encapsulate the electrically energized device by applying pressure at a temperature sufficient to form the article, wherein the temperature at an interface between the first and second layers is equal to or greater than Tg of the first layer and the second layer, and wherein the polyester layers have a flow during encapsulation less than the flow that induces fractures in the electrically energized device.
    Type: Application
    Filed: July 13, 2007
    Publication date: April 10, 2008
    Inventors: Ryan Thomas Neill, Gary Wayne Hartley, Michael Eugene Donelson, Theodore Robert Trautman, John Walker Gilmer, James Collins Maine, Bryan Steven Bishop, Robert Erik Young
  • HAND TOOLS
    Publication number: 20080016701
    Abstract: A pruner has a movable handle/blade assembly pivotally coupled to a static handle/blade assembly by a pivot assembly carried by the static handle. The pivot assembly comprises a bush within the static handle and on which the movable handle/blade assembly is pivotally mounted, a spring for pivotally biasing the movable handle/blade assembly to an open position being retained by the pivot assembly within the static handle. Both the movable blade and static blade are mounted on the bush and are clamped laterally between two separate parts of the bush which are assembled together in screw threaded engagement, and the two blades are supported from the bush by a bearing ring of low friction material.
    Type: Application
    Filed: January 25, 2007
    Publication date: January 24, 2008
    Applicant: ITW AUSTRALIA PTY LIMITED
    Inventors: Nathan Pollock, James Collins, Lee Rodezno, Peter Williams
  • SHOCK-RELEASE FLUID FRACTURING METHOD AND APPARATUS
    Publication number: 20070295508
    Abstract: A shock tool is adapted to a bottom hole tool assembly for isolating a zone in a subterranean formation accessed by a wellbore. Fracturing fluid such as nitrogen is accumulated at fracturing pressures uphole of the shock tool for subsequent and rapid release to the formation. Coal bed methane seams are particularly well suited to such a shock fracturing methodology. The tool assembly can be suspended from a conveyance string in which fluid is accumulated for shock release through a valve of the shock tool and through an injection tool to the zone isolated by the injection tool. After a first zone is shocked, the tool assembly can be moved to a new zone, or multiple shocks can be applied cyclically at the selected zone.
    Type: Application
    Filed: October 25, 2006
    Publication date: December 27, 2007
    Applicant: FRAC SOURCE INC.
    Inventors: James COLLINS, Mark T. ANDREYCHUK
  • Microphone Assembly with Preamplifier and Manufacturing Method Thereof
    Publication number: 20070286445
    Abstract: A microphone assembly include a microphone housing unit having a cover and a base. The microphone assembly further includes a preamplifier circuit assembly attached to the base and protected by the cover. The protected preamplifier circuit assembly has at least one terminal unprotected by the cover. A radio frequency interference suppression device can be electrically coupled to the preamplifier circuit and includes at least one internal ground electrically coupled to the at least one terminal. The at least one internal ground provides a ground path between the cover and the base.
    Type: Application
    Filed: April 30, 2007
    Publication date: December 13, 2007
    Applicant: KNOWLES ELECTRONICS, LLC
    Inventor: James Collins
  • Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
    Patent number: 7282513
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: October 16, 2007
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian James Collins, Laura Catherine Cooper, Timothy Harrison, Linda Elizabeth Keown, Andrew Madin, Mark Peter Ridgill
  • Pruner
    Patent number: D571169
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: June 17, 2008
    Assignee: ITW Australia Pty Ltd.
    Inventors: Nathan Pollock, James Collins, Lee Rodezno, Peter Williams