Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.

Abstract: A fluid extraction device is provided for extracting fluid from a syringe assembly including a syringe port and a sleeve. The device includes a body with first and second ends, the first end defining a fluid entry port, and the second end defining a fluid exit port. A channel through the body connects the fluid entry and fluid exit ports. At least one push member extends radially from the body and is configured to contact the sleeve of the syringe assembly in use such to push it from a first position in which the sleeve closes the syringe port to a second position in which the sleeve exposes the syringe port.

Abstract: A retaining clip tower includes a locking feature with a circular opening for a clip stem to be inserted and a rectangular opening disposed below the circular opening that can allow for a lower flange of a clip to be inserted at an angle into the locking feature wherein that the clip can complete the angled slide in such that the entire clip sits level inside the locking feature with the lower flange disposed below the locking feature and such that the clip resists extraction against vertical and horizontal forces.

Abstract: A rotor for a compressor system includes a rotor body having a coolant manifold with an inlet runner and a plurality of coolant supply conduits extending from the inlet runner toward an inner heat exchange surface. The coolant supply conduits may have a circumferential and axial distribution, and extend through struts enhancing stiffness in the rotor body.

Abstract: An introducer and a delivery assembly for introduction of a prosthesis into a bodily lumen is disclosed. The introducer comprises: a sheath; a housing mounted to a distal end of the sheath, the housing having a passage there-through adapted to receive a delivery assembly; a port for introducing flushing fluid, the port communicating with the passage; and a liquid absorbing seal for sealably receiving the delivery assembly, the liquid absorbing seal disposed within the housing distally of the port. The delivery assembly comprises: a guide wire catheter; a tip mounted to a proximal end of the guide wire catheter; a distal delivery member mounted around the guide wire catheter and located distal of the tip; and a prosthesis receiving portion between the tip and the distal delivery member. The delivery assembly is slidably mounted through the introducer. Absorption of fluid swells the liquid absorbing seal.

Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes. The invention also relates to manufacturing and using arrays and analytical approaches based on single molecule detection techniques.

Abstract: This invention relates to cellulose ester compositions cable of being calendered. The invention also relates to calendered films or sheets comprising the cellulose ester compositions and processes for calendering the cellulose compositions.

Abstract: An endoluminal delivery device assembly is disclosed. The assembly comprises: an introducer including a seal housing assembly, housing a seal, and an sheath extending proximally therefrom; a delivery device including a handle body and a pusher catheter extending from the body, the pusher catheter having a pusher catheter external surface, the pusher catheter extending through the introducer such that the external surface slideably engages with the seal; a guide wire catheter extending through the body and through the pusher, the guide wire catheter being affixed at a proximal end thereof to a tip assembly; and a linking portion for linking the body and the seal housing assembly together, the linking portion having an unlinked condition and a linked condition. In the linked condition, sliding movement between the pusher catheter and the seal is limited such that disengagement between the pusher catheter external surface and the seal is prevented.

Abstract: An endovascular delivery device comprises an outer handle with a track; an inner handle moveable relative to the outer handle; a tip assembly slider mounted on the track; the tip assembly having a top cap and a retriever, the top cap comprising a mouth receiving a proximal portion of the endograft and closable by the retriever; a connector extending from the tip to the inner handle and including a distal portion slidably engaging the inner handle; a pusher catheter extending from the outer handle assembly; a guidewire catheter; a distal trigger wire operable to release the distal end of the endograft; a proximal trigger wire release slider mounted on the track and movable from an initial to a triggered position, wherein the tip assembly slider engages the trigger wire release slider to prevent distal movement until the trigger wire release slider is moved distally.

Abstract: An introducer and a delivery assembly for introduction of a prosthesis into a bodily lumen is disclosed. The introducer comprises: a sheath; a housing mounted to a distal end of the sheath, the housing having a passage there-through adapted to receive a delivery assembly; a port for introducing flushing fluid, the port communicating with the passage; and a liquid absorbing seal for sealably receiving the delivery assembly, the liquid absorbing seal disposed within the housing distally of the port. The delivery assembly comprises: a guide wire catheter; a tip mounted to a proximal end of the guide wire catheter; a distal delivery member mounted around the guide wire catheter and located distal of the tip; and a prosthesis receiving portion between the tip and the distal delivery member. The delivery assembly is slidably mounted through the introducer. Absorption of fluid swells the liquid absorbing seal.

Abstract: Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) are also provided.

Abstract: An especially robust compound and its derivative metal complexes that are approximately one hundred-fold superior in catalytic performance to the previously invented TAML analogs is provided having the formula: wherein Y1, Y2, Y3 and Y4 are oxidation resistant groups which are the same or different and which form 5- or 6-membered rings with a metal, M, when bound to D; at least one Y incorporates a group that is significantly more stable towards nucleophilic attack than the organic amides of TAML activators; D is a metal complexing donor atom, preferably N; each X is a position for addition of a labile Lewis acidic substituent such as (i) H, deuterium, (ii) Li, Na, K, alkali metals, (iii) alkaline earth metals, transition metals, rare earth metals, which may be bound to one or more than one D, (iv) or is unoccupied with the resulting negative charge being balanced by a nonbonded countercation; at least one Y may contain a site that is labile to acid dissociation, providing a mechanism for shortening co

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

Abstract: A fluid extraction device is provided for extracting fluid from a syringe assembly including a syringe port and a sleeve. The device includes a body with first and second ends, the first end defining a fluid entry port, and the second end defining a fluid exit port. A channel through the body connects the fluid entry and fluid exit ports. At least one push member extends radially from the body and is configured to contact the sleeve of the syringe assembly in use such to push it from a first position in which the sleeve closes the syringe port to a second position in which the sleeve exposes the syringe port.

Abstract: The invention relates to methods of detecting a genetic variation in a genetic sample from a subject using labeled probes and counting the number of labels in the probes.

Abstract: A low flying unmanned vehicle is disclosed that may be able to determine whether a collision is possible and may take evasive action in response to the possible collision. The vehicle may wirelessly communicate and may use a standard protocol such that a variety of additional objects may be taken into account when determining the possible collision risk.

Abstract: Certain embodiments provide a system and method for measurement of the force applied to a bone-conduction oscillator during application to a subject, resolving the measured force relative to a pre-determined criteria, and providing an indication to the user to specify whether an external force applied to an applied force indication system coupled with a bone-conduction oscillator is within a pre-determined acceptable range. A mechanical arrangement is prescribed which allows the full extent of the force applied to be represented onto the pressure measurement apparatus. The system and apparatus may be applied onto or integrated into bone-conduction oscillators.