Patents by Inventor James Cook

James Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240101553
    Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
    Type: Application
    Filed: August 4, 2023
    Publication date: March 28, 2024
    Inventors: Matthew Arnold MARX, James Gail CHRISTENSEN, Christopher Ronald SMITH, James F. BLAKE, Laurence E. BURGESS, Mark Joseph CHICARELLI, Adam COOK, Jay Bradford FELL, John P. FISCHER, Macedonio J. MEJIA, Martha E. RODRIGUEZ, Pavel SAVECHENKOV, Tony P. TANG, Guy P.A. VIGERS
  • Publication number: 20240103960
    Abstract: Approaches for monitoring and managing one or more operational components of a data center are provided. Data for one or more applications associated with operational functionalities may be received. The one or more applications may be associated with one or more related applications. A failure of one or more components monitored by the one or more applications or the one or more related applications can be detected. A cause of the failure can be determined based, at least in part, upon detected changes and contextual information associated with the failure. At least one change can be made to the components based on the determined cause.
    Type: Application
    Filed: December 14, 2022
    Publication date: March 28, 2024
    Inventor: Paul James Cook
  • Patent number: 11938154
    Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). The endothelial progenitor cell-derived exosomes can be modified to overexpress one or more miRNAs.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: March 26, 2024
    Assignee: MUSC Foundation for Research Development
    Inventors: Hongkuan Fan, Andrew Goodwin, Perry V. Halushka, James A Cook, Yue Zhou
  • Publication number: 20240093824
    Abstract: Methods of sealing tubulars are disclosed herein, which methods may include: providing a patch plug assembly that includes: a shaft; a wedge coupled to the shaft; a slip coupled to the shaft; a plug slidably coupled to the wedge; and a ferrule disposed between the wedge and the plug; pushing the slip against the tubular; pushing the plug against the ferrule after the slip is pushed against the tubular; pushing the ferrule against the wedge after the plug is pushed against the ferrule; and pushing a plug portion of the plug against an inner surface of the tubular.
    Type: Application
    Filed: November 27, 2023
    Publication date: March 21, 2024
    Inventors: Glenn Mitchel Walls, Robert Bradley Cook, Daniel Teen, Paul James Wilson
  • Publication number: 20240093559
    Abstract: A pipe deployment system includes a vehicle, a deployment tool having a body with a spool engagement slot and a hydraulic motor mounted to the body, a spool having a pin extending along a rotational axis of the spool from an end of the spool, and an engagement spline rotationally engaging the hydraulic motor with the pin. The deployment tool is removably connected to the vehicle.
    Type: Application
    Filed: September 21, 2022
    Publication date: March 21, 2024
    Applicant: FMC Technologies, Inc.
    Inventors: James Cook, Corey Massey, Julian Keihany, Thiago Machado, Rajeev Pillai
  • Patent number: 11926619
    Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: March 12, 2024
    Assignee: Eisai R & D Management Co., Ltd.
    Inventors: Gregg F. Keaney, John Wang, Baudouin Gerard, Kenzo Arai, Xiang Liu, Guo Zhu Zheng, Kazunobu Kira, Lisa A. Marcaurelle, Marta Nevalainen, Ming-Hong Hao, Morgan Welzel O'Shea, Parcharee Tivitmahaisoon, Sudeep Prajapati, Tuoping Luo, Nicholas C. Gearhart, Jason T. Lowe, Yoshihiko Kotake, Satoshi Nagao, Regina Mikie Kanada Sonobe, Masayuki Miyano, Norio Murai, Andrew Cook, Shelby Ellery, Atsushi Endo, James Palacino, Dominic Reynolds
  • Publication number: 20240066029
    Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
    Type: Application
    Filed: June 27, 2023
    Publication date: February 29, 2024
    Inventors: Steven W. ANDREWS, Sean ARONOW, James F. Blake, Barbara J. BRANDHUBER, Adam COOK, Julia HAAS, Yutong JIANG, Gabrielle R. KOLAKOWSKI, Elizabeth A. MCFADDIN, Megan L. MCKENNEY, Oren T. MCNULTY, Andrew T. METCALF, David A. MORENO, Tony P. TANG, Li REN
  • Publication number: 20240063661
    Abstract: A wireless power transmitter includes a charging coil, an electronics housing, and a top side. The charging coil housing houses a charging coil and includes a top surface, wherein the charging coil wirelessly transmits power to a receiver placed on the top surface of the charging coil housing. The electronics housing houses one or more electronics and a fan. The top side is located adjacent to the electronics housing, wherein a top surface of the top side faces a bottom surface of the receiver. An intake cooling path is defined by a region between the bottom surface of the receiver and the top surface of the top side and an exhaust cooling path is located on a side of the charging coil housing opposite the intake cooling path and defined by a region between the receiver and the top surface of the top side.
    Type: Application
    Filed: October 31, 2023
    Publication date: February 22, 2024
    Inventors: George Powell, JR., James Cook, Evan Wallace
  • Patent number: 11898644
    Abstract: A diverter valve which includes a valve body, an inlet, a plurality of outlets, an internal cavity to which the inlet and the outlets are connected, and a valve member which is movably positioned in the cavity. The valve member includes a through bore which is configured to connect the inlet with a corresponding one of the outlets for each of a plurality of operative positions of the valve member. In operation of the diverter valve, the valve member is movable between its operative positions to selectively connect the inlet with any one of the outlets.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: February 13, 2024
    Inventors: James Cook, Brian J. Baca, Jeffrey Michael Partridge
  • Publication number: 20240026765
    Abstract: An illustrative modular manifold system includes, among other things, two or more modular pump manifolds, a low-pressure header, and a main high-pressure manifold. Modular pump manifolds may include a low-pressure manifold for supplying fracturing fluid or water to pumps, a high-pressure manifold for supplying fracturing fluid or water to one or more wells and a bleed-off/prime-up manifold. Each modular pump manifold of the modular manifold system is configured to be fluidly isolatable from the other modular pump manifolds. Each isolated modular pump manifold is configured to be flushed with water, bled off and primed up independently of the other modular pump manifolds. After the bleed off, maintenance procedures may be performed on pumps associated with the isolated modular pump manifold. The modular pump manifolds that are not isolated may continue in active fracing stage operations while a modular pump manifold is isolated.
    Type: Application
    Filed: September 28, 2023
    Publication date: January 25, 2024
    Applicant: FMC Technologies, Inc.
    Inventors: James Cook, Julian Keihany, Corey Massey, Andrew Krupa
  • Patent number: 11882421
    Abstract: An integrated cinema amplifier comprises a power supply stage that distributes power over a plurality of channels for rendering immersive audio content in a surround sound listening environment. The amplifier automatically detects maximum and net power availability and requirements based on audio content by decoding audio metadata and dynamically adjusts gains to each channel or sets of channels based on content and operational/environmental conditions. A power supply stage provides power to drive a plurality of channels corresponding to speaker feeds to a plurality of speakers. The amplifier has a front panel having an LED array with each LED associated with a respective channel or group of channels of the multi-channel amplifier, and a control unit configured to light the LEDs according to display patterns based on operating status or error conditions of the amplifier.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: January 23, 2024
    Assignee: Dolby Laboratories Licensing Corporation
    Inventors: Andrew Healy, Edward John Neary, Erich Hubert Vogel, Andrew Michael Poulain, Gregory J. Long, Joel A. Butler, Angela Williams, Luca Revelli, Dossym Nurmukhanov, Tanner James Cook, Marcelo Traverso M., Kenneth Schindler
  • Publication number: 20240022115
    Abstract: An electronics module is configured to provide power to one of a plurality of different types of coil modules utilized for wireless charging. The electronics module includes an input power interface configured to receive direct current (DC) power, a DC-to-AC converter circuity configured to convert the DC power to alternating current (AC) power, and an output power interface having a first set of output pins and at least a second set of output pins configured to interface with each of the plurality of different types of coil modules, wherein AC power is selectively provided to the first set of output pins, or both the first and second set of output pins based on a type of coil module connected to the electronics module.
    Type: Application
    Filed: September 29, 2023
    Publication date: January 18, 2024
    Inventor: James Cook
  • Publication number: 20240008578
    Abstract: A helmet includes an impact mitigating structure (100). The impact mitigating structure includes a first inner layer (102), a second outer layer (104) and a reactive layer (105) positioned between the first inner layer and the second outer layer. The reactive layer includes multiple elements (106) held between the first inner layer and second outer layer. The reactive layer is arranged such that, when the second layer is subject to an impact, the multiple elements of the reactive layer are configured to roll to facilitate movement of the first inner layer and the second outer layer with respect to each other.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 11, 2024
    Applicant: HEXR LTD
    Inventors: Henry NEILSON, James COOK, Adam LEVY, Robin SPICER
  • Publication number: 20230413937
    Abstract: The present invention relates to a helmet comprising an impact mitigating structure, the impact mitigating structure comprising: a first layer; and a second layer; wherein one or more of a material property, a mechanical property and a geometrical property of the impact mitigating structure is arranged to, when the impact mitigating structure is subject to an impact, facilitate at least partial fracturing of the second layer such that at least a portion of the second layer is able to move relative to the first layer.
    Type: Application
    Filed: November 19, 2021
    Publication date: December 28, 2023
    Applicant: HEXR LTD
    Inventors: James COOK, Henry NEILSON, Adam LEVY
  • Publication number: 20230408638
    Abstract: Example implementations include a system and method for providing a graphical user interface (GUI) on a display, wherein the GUI is operable for displaying a representation of a detection field of an object counting radar unit, wherein the GUI is operable for displaying a reference point that represents a rotatable object as detected by the object counting radar unit when the rotatable object is located in a field-of-view of the object counting radar unit and is rotated by a drive motor assembly.
    Type: Application
    Filed: June 15, 2023
    Publication date: December 21, 2023
    Inventors: James A. COOK, John J. CLARK
  • Patent number: 11848565
    Abstract: A wireless power transmitter includes a charging coil, an electronics housing, and a top side. The charging coil housing houses a charging coil and includes a top surface, wherein the charging coil wirelessly transmits power to a receiver placed on the top surface of the charging coil housing. The electronics housing houses one or more electronics and a fan. The top side is located adjacent to the electronics housing, wherein a top surface of the top side faces a bottom surface of the receiver. An intake cooling path is defined by a region between the bottom surface of the receiver and the top surface of the top side and an exhaust cooling path is located on a side of the charging coil housing opposite the intake cooling path and defined by a region between the receiver and the top surface of the top side.
    Type: Grant
    Filed: April 15, 2022
    Date of Patent: December 19, 2023
    Assignee: Aptiv Technologies AG
    Inventors: George Powell, Jr., James Cook, Evan Wallace
  • Publication number: 20230399908
    Abstract: A wireline pressure control string for use in performing wireline operations on a hydrocarbon well is disclosed. The wireline pressure control string includes a pumpdown assembly having a pumpdown sub and at least one pumpdown valve. The pumpdown sub includes a body and a through bore which extends axially through the body and is fluidly connectable to the well bore. The pumpdown valve includes an inlet which is fluidly connectable to a pumpdown fluid source and an outlet which is fluidly connected to the through bore. The wireline pressure control string may also include a connector positioned below the pumpdown assembly for releasably securing the wireline pressure control string to the wellhead assembly. In certain embodiments, the pumpdown valve may be connected to the pumpdown fluid source with a flexible flowline.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 14, 2023
    Inventors: Corey Massey, James Cook
  • Publication number: 20230389856
    Abstract: Methods and systems implement a variety of sensors, including in embodiments various combinations of EEG sensors, biochemical sensors, photoplethysmography (PPG) sensors, microphones, and accelerometers, to detect, predict, and/or classify various physiological events and/or conditions related to epilepsy, sleep apnea, and/or vestibular disorders. The events can include neuroelectrical events, cardiac events, and/or pulmonary events, among others. In some cases, the method and systems implement trained artificial intelligence (AI) models to detect, classify, and/or predict. The methods and systems are also capable of optimizing a treatment window, suggesting treatments that may improve the overall well-being of the patient (including improving pre- or post-event symptoms and effects), and/or interacting with various care providers.
    Type: Application
    Filed: November 16, 2021
    Publication date: December 7, 2023
    Inventors: John Michael Heasman, Mark James Cook, Robert John Klupacs, Rohan J. Hoare
  • Publication number: 20230374980
    Abstract: A modular pump skid includes a base, a prime mover mounted on the base, and one or more hydraulic pump circuits removably mounted on the base and operationally coupled to the prime mover, wherein each hydraulic pump circuit has a hydraulic pump operationally coupled to the prime mover and a hydraulically driven pump fluidly coupled to the hydraulic pump. Each hydraulic pump circuit is in a closed loop independent of other hydraulic pump circuits.
    Type: Application
    Filed: August 2, 2023
    Publication date: November 23, 2023
    Applicant: FMC Technologies, Inc.
    Inventor: James Cook
  • Patent number: 11808126
    Abstract: An illustrative modular manifold system includes, among other things, two or more modular pump manifolds, a low-pressure header, and a main high-pressure manifold. Modular pump manifolds may include a low-pressure manifold for supplying fracturing fluid or water to pumps, a high-pressure manifold for supplying fracturing fluid or water to one or more wells and a bleed-off/prime-up manifold. Each modular pump manifold of the modular manifold system is configured to be fluidly isolatable from the other modular pump manifolds. Each isolated modular pump manifold is configured to be flushed with water, bled off and primed up independently of the other modular pump manifolds. After the bleed off, maintenance procedures may be performed on pumps associated with the isolated modular pump manifold. The modular pump manifolds that are not isolated may continue in active fracing stage operations while a modular pump manifold is isolated.
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: November 7, 2023
    Assignee: FMC Technologies, Inc.
    Inventors: James Cook, Julian Keihany, Corey Massey, Andrew Krupa