Abstract: A diverter valve which includes a valve body, an inlet, a plurality of outlets, an internal cavity to which the inlet and the outlets are connected, and a valve member which is movably positioned in the cavity. The valve member includes a through bore which is configured to connect the inlet with a corresponding one of the outlets for each of a plurality of operative positions of the valve member. In operation of the diverter valve, the valve member is movable between its operative positions to selectively connect the inlet with any one of the outlets.

Abstract: As described herein, a gateway device may include one or more expansion ports to add functionality. The added functionality can be of any desired type, such as adding telephone call routing capabilities, or high-definition radio capabilities. The added functionality can include new wireless communication abilities, such as adding Bluetooth capability, and the combination may allow greater networked communication.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: The electronic device may invoke a host application. The device may display a first host user interface on the display, the first host user interface including a first host user interface component associated with a child application. In response, the device may invoke, using the host application, the child application executed at the electronic device. The device may transmit, using the host application, a request for data associated with a child user interface component to the child application. The device may transmit, using the child application, the request for data associated with the child user interface component to a child application server, wherein the data associated with the child user interface component is inaccessible by the host application. The device may receive, using the child application, the data associated with the child user interface component from the child application server. The device may display the child user interface component.

Abstract: The electronic device may invoke a host application. The device may display a first host user interface on the display, the first host user interface including a first host user interface component associated with a child application. In response, the device may invoke, using the host application, the child application executed at the electronic device. The device may transmit, using the host application, a request for data associated with a child user interface component to the child application. The device may transmit, using the child application, the request for data associated with the child user interface component to a child application server, wherein the data associated with the child user interface component is inaccessible by the host application. The device may receive, using the child application, the data associated with the child user interface component from the child application server. The device may display the child user interface component.

Abstract: The present invention provides a system for intracranial imaging and treatment of an intracranial region including: (a) a catheter probe suitable for insertion into the intracranial region, the catheter probe including: (i) a catheter housing; (ii) an optical probe including one or more optical emitters; and (iii) an optional surgical tool, with the optical probe and the surgical tool located within the housing; and (b) an imaging plate configured for fixed attachment through a plurality of fixed attachment points to a surface of the intracranial region being imaged and treated. The imaging plate includes an array of sensors, each sensor including an optical receiver. The optical emitters are configured to emit light in proximity to the intracranial region being imaged. The array of sensors is configured to measure transmitted light to determine the status of the intracranial region being imaged.

Abstract: The invention relates to a detergent composition comprising: —(a) from 0.0001 to 1 wt. %, preferably from 0.0001 to 0.1 wt. %, more preferably from 0.0001 to 0.01 wt. %, most preferably from 0.0005 to 0.001 wt. % of a shading dye; and, (b) from 0.0001 to 10 wt. %, preferably from 0.0005 to 8 wt. %, more preferably from 0.001 to 5 wt. %, most preferably from 0.002 to 0.2 wt. % of a cellulase selected from any sequence with a sequence identity of at least 80%, preferably at least 85%, further preferred at least 90%, GO even more preferred at least 92%, also preferred at least 95%, particularly preferred at least 98% and most preferred at least 99% to SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15 or SEQ ID NO: 17.

Abstract: Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.

Abstract: A system comprising: an additive manufacturing apparatus configured to perform an additive manufacturing process using a feedstock supplied thereto, thereby to produce an article; a feedstock storage module configured to supply feedstock to the additive manufacturing apparatus; a machining apparatus configured to perform a machining process; a controller configured to control operation of the additive manufacturing apparatus and the machining apparatus; and are cycling module configured to receive a waste material and to produce the feedstock therefrom, and to transfer the produced feedstock to the feedstock storage module. The additive manufacturing apparatus and the machining apparatus comprise a common heat source, the additive manufacturing apparatus configured to use the common heat source to perform the additive manufacturing process, and the machining apparatus configured to use the common heat source to perform the machining process.

Abstract: Technology for a repeater is disclosed. The repeater can include a first defined connection. The repeater can include a first coaxial cable connector configured to be communicatively coupled to the first defined connection. The repeater can include a repeater unit communicatively coupled to the first defined connection. The repeater can include a controller configured to adjust a gain or output power of the repeater unit that compensates for insertion losses between the first coaxial cable connector and the first defined connection.

Abstract: The present disclosure generally relates to novel chimeric antigen receptors (“CARs”), modified regulatory T cells (“Tregs”) expressing such CARs and/or Tregs which are engineered to express neurodegenerative disease modifying molecules, e.g., which express molecules which prevent oxidative/inflammatory activity, or which promote neuronal growth/survival such as nerve growth factors or non-classical neurotrophic factors. The present disclosure also generally relates to compositions containing such modified Tregs, and methods of use thereof as therapeutics, in particular for treating and preventing neurodegenerative diseases and symptoms associated with therewith, and/or for slowing the onset of such neurodegenerative diseases, particularly in persons at risk because of genetic factors or in persons exhibiting early signs of developing such a neurodegenerative disease.

Abstract: Technology for a low-noise signal chain is disclosed. The low-noise signal chain can include a signal path configured to carry a signal. The low-noise signal chain can include a bypassable amplifier communicatively coupled to the signal path. The low-noise signal chain can include a switchable band pass filter communicatively coupled to the signal path. The low-noise signal chain can include an amplifier bypass path communicatively coupled to the signal path. The signal can be configured to be directed to the amplifier bypass path to bypass the bypassable amplifier. The low-noise signal chain can include a band pass filter bypass path communicatively coupled to the signal path. The signal can be configured to be directed to the band pass filter bypass path to bypass the switchable band pass filter.

Abstract: Provided herein are compounds of the Formula I: or pharmaceutically acceptable salt or solvate thereof, wherein A, B, X1, X2, X3, X4, Ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: A system comprising: an additive manufacturing apparatus configured to perform an additive manufacturing process using a feedstock supplied thereto, thereby to produce an article; a feedstock storage module configured to supply feedstock to the additive manufacturing apparatus; a machining apparatus configured to perform a machining process; a controller configured to control operation of the additive manufacturing apparatus and the machining apparatus; and are cycling module configured to receive a waste material and to produce the feedstock therefrom, and to transfer the produced feedstock to the feedstock storage module. The additive manufacturing apparatus and the machining apparatus comprise a common heat source, the additive manufacturing apparatus configured to use the common heat source to perform the additive manufacturing process, and the machining apparatus configured to use the common heat source to perform the machining process.

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

Abstract: The electronic device may invoke a host application. The device may display a first host user interface on the display, the first host user interface including a first host user interface component associated with a child application. In response, the device may invoke, using the host application, the child application executed at the electronic device. The device may transmit, using the host application, a request for data associated with a child user interface component to the child application. The device may transmit, using the child application, the request for data associated with the child user interface component to a child application server, wherein the data associated with the child user interface component is inaccessible by the host application. The device may receive, using the child application, the data associated with the child user interface component from the child application server. The device may display the child user interface component.

Abstract: The invention provides a polishing pad suitable for polishing or planarizing at least one of semiconductor, optical and magnetic substrates. The polishing pad includes a polishing layer having a polymeric matrix, a thickness and a polishing track representing a working region of the polishing layer for polishing or planarizing. Radial drainage grooves extend through the polishing track facilitate polishing debris removal through the polishing track and underneath the at least one of semiconductor, optical and magnetic substrates and then beyond the polishing track toward the perimeter of the polishing pad during rotation of the polishing pad.

Abstract: Examples include a fluid ejection die having a die length and a die width. The fluid ejection die may include a plurality of nozzles arranged along the die length and a die width. The plurality of nozzles is arranged such that at least one pair of neighboring nozzles are positioned at different die width positions along the width of the fluid ejection die. The example fluid ejection die further includes a plurality of ejection chambers including a respective ejection chamber fluidically coupled to each respective nozzle. The fluid ejection die further includes an array of fluid feed holes. The array of fluid feed holes includes a first respective fluid feed hole fluidically coupled to each respective ejection chamber, and the array of fluid feed holes includes a second respective fluid feed hole fluidically coupled to each respective ejection chamber.

Abstract: Examples include a fluid ejection die having a die length and a die width. The fluid ejection die may include a plurality of nozzles arranged along the die length and a die width. The plurality of nozzles is arranged such that at least one pair of neighboring nozzles are positioned at different die width positions along the width of the fluid ejection die. The example fluid ejection die further includes a plurality of ejection chambers including a respective ejection chamber fluidically coupled to each respective nozzle. The fluid ejection die further includes an array of fluid feed holes. The array of fluid feed holes includes at least one fluid feed hole fluidically each respective ejection chamber.