Abstract: This disclosure relates to uses of radiation and benzodiazepines optionally in combination with other anticancer agents for treating cancer. In certain embodiments, this disclosure relates to methods of using radiation, benzodiazepines, and check point inhibitors in cancer therapies.

Abstract: A modular pump skid includes a base, a prime mover mounted on the base, and one or more hydraulic pump circuits removably mounted on the base and operationally coupled to the prime mover, wherein each hydraulic pump circuit has a hydraulic pump operationally coupled to the prime mover and a hydraulically driven pump fluidly coupled to the hydraulic pump. Each hydraulic pump circuit is in a closed loop independent of other hydraulic pump circuits.

Abstract: A zipper manifold for use in wellbore operations includes a trunk line having a first longitudinal axis, an inlet on a first axial end, an outlet on a second axial end, and a first gate valve positioned between the inlet and the outlet, a block tee fluidly connecting the trunk line to a secondary line, the secondary line having a second longitudinal axis parallel to the first longitudinal axis, a second gate valve positioned along the secondary line, and an outlet head at an end of the secondary line.

Abstract: Disclosed are embodiments for facilitating generation of training data, which includes information regarding a set of physical tasks or cognitive tasks to be performed by a user (e.g., separately or concurrently), and adjusting the training data based on a performance of the user. The tasks may be directed to improving a specific health condition (e.g., balance capabilities of the user). The system obtains sensor data that is representative of user actions in performance of the tasks from sensors of a user device. The sensor data may be processed to determine performance data (e.g., physical or cognitive performance) that is indicative of the performance of the user in performing the tasks. The training data may be adjusted based on the performance data (e.g., one or more tasks or task parameters are adjusted to increase or decrease a difficulty level for the user in performing the tasks).

Abstract: A valve block may be assembled, in a controlled environment, a valve block to be modular and purpose built for a specific application. The specific application may be an operation to be performed at a well site. The modular purpose built valve block may be function tested, in the controlled environment. Additionally, the modular purpose built valve block may be pre-packaged, in the controlled environment, to have a digital system to operate and automate the modular purpose built valve block. Further, the modular pre-packaged purpose built valve block may be deployed to the well site, and the modular pre-packaged purpose built valve block may be fluidly coupled to a wellhead. The modular pre-packaged purpose built valve block may be operated to perform the operation at the well site.

Abstract: A modular pumping pad skid may include a base with one or more high pressure fluid conduits and one or more low pressure conduits. Additionally, two or more pumps may be removably fixed to the base, and fluidly connected to the high pressure fluid conduits and the low pressure conduits.

Abstract: A method for performing simultaneous operations at a wellsite comprising two or more adjacent wellheads, each respectively connected to a well, may include the following steps: providing a fluid supply via upstream equipment to an intermediate supply point; fluidly connecting the intermediate supply point to a single wellhead, the fluidly connecting comprising connecting a first end of a flexible pipe to the intermediate supply point and a second end of the flexible pipe to a first wellhead; performing a wellbore operation on a first well using the fluid supply from the upstream equipment supplied to the first wellhead; disconnecting the second end of the flexible pipe from the first wellhead; and connecting the second end of the flexible pipe to a second wellhead.

Abstract: A diverter valve which includes a valve body, an inlet, a plurality of outlets, an internal cavity to which the inlet and the outlets are connected, and a valve member which is movably positioned in the cavity. The valve member includes a through bore which is configured to connect the inlet with a corresponding one of the outlets for each of a plurality of operative positions of the valve member. In operation of the diverter valve, the valve member is movable between its operative positions to selectively connect the inlet with any one of the outlets.

Abstract: The present invention provides a system for intracranial imaging and treatment of an intracranial region including: (a) a catheter probe suitable for insertion into the intracranial region, the catheter probe including: (i) a catheter housing; (ii) an optical probe including one or more optical emitters; and (iii) an optional surgical tool, with the optical probe and the surgical tool located within the housing; and (b) an imaging plate configured for fixed attachment through a plurality of fixed attachment points to a surface of the intracranial region being imaged and treated. The imaging plate includes an array of sensors, each sensor including an optical receiver. The optical emitters are configured to emit light in proximity to the intracranial region being imaged. The array of sensors is configured to measure transmitted light to determine the status of the intracranial region being imaged.

Abstract: Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.

Abstract: A system comprising: an additive manufacturing apparatus configured to perform an additive manufacturing process using a feedstock supplied thereto, thereby to produce an article; a feedstock storage module configured to supply feedstock to the additive manufacturing apparatus; a machining apparatus configured to perform a machining process; a controller configured to control operation of the additive manufacturing apparatus and the machining apparatus; and are cycling module configured to receive a waste material and to produce the feedstock therefrom, and to transfer the produced feedstock to the feedstock storage module. The additive manufacturing apparatus and the machining apparatus comprise a common heat source, the additive manufacturing apparatus configured to use the common heat source to perform the additive manufacturing process, and the machining apparatus configured to use the common heat source to perform the machining process.

Abstract: The present disclosure generally relates to novel chimeric antigen receptors (“CARs”), modified regulatory T cells (“Tregs”) expressing such CARs and/or Tregs which are engineered to express neurodegenerative disease modifying molecules, e.g., which express molecules which prevent oxidative/inflammatory activity, or which promote neuronal growth/survival such as nerve growth factors or non-classical neurotrophic factors. The present disclosure also generally relates to compositions containing such modified Tregs, and methods of use thereof as therapeutics, in particular for treating and preventing neurodegenerative diseases and symptoms associated with therewith, and/or for slowing the onset of such neurodegenerative diseases, particularly in persons at risk because of genetic factors or in persons exhibiting early signs of developing such a neurodegenerative disease.

Abstract: A system comprising: an additive manufacturing apparatus configured to perform an additive manufacturing process using a feedstock supplied thereto, thereby to produce an article; a feedstock storage module configured to supply feedstock to the additive manufacturing apparatus; a machining apparatus configured to perform a machining process; a controller configured to control operation of the additive manufacturing apparatus and the machining apparatus; and are cycling module configured to receive a waste material and to produce the feedstock therefrom, and to transfer the produced feedstock to the feedstock storage module. The additive manufacturing apparatus and the machining apparatus comprise a common heat source, the additive manufacturing apparatus configured to use the common heat source to perform the additive manufacturing process, and the machining apparatus configured to use the common heat source to perform the machining process.

Abstract: The present disclosure generally relates to novel chimeric antigen receptors (“CARs”), modified regulatory T cells (“Tregs”) expressing such CARs and/or Tregs which are engineered to express neurodegenerative disease modifying molecules, e.g., which express molecules which prevent oxidative/inflammatory activity, or which promote neuronal growth/survival such as nerve growth factors or non-classical neurotrophic factors. The present disclosure also generally relates to compositions containing such modified Tregs, and methods of use thereof as therapeutics, in particular for treating and preventing neurodegenerative diseases and symptoms associated with therewith, and/or for slowing the onset of such neurodegenerative diseases, particularly in persons at risk because of genetic factors or in persons exhibiting early signs of developing such a neurodegenerative disease.

Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS).

Abstract: Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.

Abstract: A connector block having a single piece body may be configured for use in a Christmas tree. The connector block may include an axial bore formed therethrough, one or more valve chambers, passing fully through the connector block and intersecting the axial bore, one or more frac bores, extending from an outer surface of the connector block to the axial bore; and, one or more wing bores, extending from the outer surface of the connector block to the axial bore.

Abstract: An electrode device is disclosed comprising: an elongate, implantable body comprising elastomeric material, a plurality of electrodes positioned along a length of the implantable body; an electrical connection comprising one or more conductive elements extending through the elastomeric material and electrically connecting to the electrodes; and a reinforcement device extending through the elastomeric material. The length of the implantable body is extendible by placing the implantable body under tension. The reinforcement device limits the degree by which the length of the implantable body can extend under tension. At least one of the electrodes can extend circumferentially around a portion of the implantable body. A delivery device and method of delivery for an electrode device is also disclosed.

Abstract: Disclosed is a method and apparatus for machining a workpiece (2). The method comprises specifying a path along which a cutting tool (6) is moved during machining the workpiece (2), the path comprising segments (26); defining, for each segment (26), an exit point on that segment (26); defining, for each segment (26), an exit path (38) from the exit point of that segment (26) to a point remote from the workpiece (2); performing a machining process including moving the cutting tool (6) along the tool path and machining the workpiece (2); and, during the machining process, when one or more criteria are satisfied: interrupting the machining process and, without machining the workpiece (2), moving the cutting tool (6) to the exit point of the current segment (26) and then along the exit path (38) of the current segment (26).

Abstract: An electrode device is disclosed comprising: an elongate, implantable body comprising elastomeric material, a plurality of electrodes positioned along a length of the implantable body; an electrical connection comprising one or more conductive elements extending through the elastomeric material and electrically connecting to the electrodes; and a reinforcement device extending through the elastomeric material. The length of the implantable body is extendible by placing the implantable body under tension. The reinforcement device limits the degree by which the length of the implantable body can extend under tension. At least one of the electrodes can extend circumferentially around a portion of the implantable body. A delivery device and method of delivery for an electrode device is also disclosed.