Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.

Abstract: A system for communications between a lunar or planetary surface and the Earth may include a first communications satellite adapted to be positioned in a predetermined orbit relative to a celestial body. A first antenna may be mounted on the first communications satellite. The first antenna may include a predetermined beam shape for communications between the first communications satellite and an asset on the lunar or planetary surface. A second antenna may also be mounted on the first communications satellite. The second antenna may include a selected beam shape for communications between the first communications satellite and the Earth. A communications system may be included for relaying communications between the first and second antennas.

Abstract: A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.

Abstract: A system for communications between a lunar or planetary surface and the Earth may include a first communications satellite adapted to be positioned in a predetermined orbit relative to a celestial body. A first antenna may be mounted on the first communications satellite. The first antenna may include a predetermined beam shape for communications between the first communications satellite and an asset on the lunar or planetary surface. A second antenna may also be mounted on the first communications satellite. The second antenna may include a selected beam shape for communications between the first communications satellite and the Earth. A communications system may be included for relaying communications between the first and second antennas.

Abstract: A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.

Abstract: Methods and apparatus are provided for stabilizing the phase and gain of an amplifier in a power pooling arrangement. A pilot signal combining a reference carrier frequency with a reference sideband frequency is passed through the amplifier via an adjustable phase shifter and an adjustable attenuator in the amplifier input line. A portion of the amplified pilot signal is coupled from the output of the amplifier and mixed with the reference frequency. The remaining audio frequency signal is compared to a reference (input) audio signal to determine phase and gain changes during amplification in the amplifier. Phase and gain control signals are developed from this comparison, and are fed back to the adjustable phase shifter and adjustable attenuator, respectively, in order to compensate an incoming signal for phase and gain variations in the amplifier.

Abstract: A transcribed non-naturally occurring RNA molecule comprising a desired RNA molecule, wherein the 3? region of the RNA is able to base-pair with at least 8 bases at the 5? terminus of the same RNA molecule.

Abstract: A system and method for adjusting satellite communication signal transmit power for signals transmitted to a localized region within a satellite coverage area utilize real-time information on weather conditions (172) and/or actual path losses (174) within the localized regions to adjust the effective isotropic radiated power (EIRP) of the satellite beams (188) to minimize the total radio frequency (RF) power required for transmission. The transmission system may be realized using a variety of antenna types for transmitting spot beams and/or area coverage beams. Representative antenna implementations include multi-beam antennas having a low-level beamforming network and hybrid matrix amplifier system, phased-array with independent input amplitude control and beamsteering for each beam, and a phased-array feeding a confocal imaging system for single broadcast beam per polarization.

Abstract: The present invention relates to an enzymatic RNA molecule which cleaves mRNA derived from c-myc gene.

Abstract: An enzymatic RNA molecule which specifically cleaves mRNA encoded by an mdr-1 gene.

Abstract: The present invention relates to an enzymatic RNA molecule which cleaves mRNA derived from c-myc gene.

Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of Burkitt's lymphoma or acute lymphocytic leukemia.

Abstract: The present invention provides methods for identifying drugs that are most specific for their intended molecular targets utilizing compounds specific for the molecular targets as model drugs in cultured cells. In various embodiments, methods are described for use of the present invention to identify non-target effects of drugs. The present invention also provides methods to identify other molecular targets for disease intervention besides the intended molecular targets of the drugs. Compounds specific for their molecular targets are preferably antisense agents.

Abstract: Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.

Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of lung cancer.