Patents by Inventor James D. Thompson

James D. Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10357647
    Abstract: A method and device for implanting a medical lead. The device includes an elongate shaft defining a major longitudinal axis and including a proximal end and a distal end. A necked portion coupled to and extending from the distal end is included, the necked portion defines a first thickness and a substantially planar surface, the necked portion being at least resiliently movable in a direction normal to the major longitudinal axis. A tip disposed at the distal end of the necked portion is included, the tip defining a second thickness greater than the first thickness.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: July 23, 2019
    Assignee: Medtronic, Inc.
    Inventors: Kenneth C. Gardeski, James K. Carney, Melissa G. T. Christie, Michael R. Leners, Lonnie D. Ronning, Amy E. Thompson-Nauman
  • Publication number: 20190192684
    Abstract: An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 27, 2019
    Inventors: James D. PIPKIN, Rupert O, ZIMMERER, Diane O. THOMPSON, Gerold L. MOSHER
  • Publication number: 20160304879
    Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 20, 2016
    Inventors: Shai Erlich, James D. Thompson, Rabia Ozden, Elena Feinstein
  • Patent number: 9382542
    Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: July 5, 2016
    Assignee: Quark Pharmaceuticals, Inc.
    Inventors: Shai Erlich, James D. Thompson, Rabia Ozden
  • Publication number: 20140371439
    Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 3, 2013
    Publication date: December 18, 2014
    Inventors: Shai Erlich, James D. Thompson, Rabia Ozden
  • Patent number: 8765931
    Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: July 1, 2014
    Assignee: Quark Pharmaceuticals, Inc.
    Inventors: Elena Feinstein, Evgenia Alpert, Igor Mett, Amir Bar-Ilan, Igor Spivak, Hagar Kalinski, Netanja Slager, James D. Thompson
  • Patent number: 8639181
    Abstract: A system for communications between a lunar or planetary surface and the Earth may include a first communications satellite adapted to be positioned in a predetermined orbit relative to a celestial body. A first antenna may be mounted on the first communications satellite. The first antenna may include a predetermined beam shape for communications between the first communications satellite and an asset on the lunar or planetary surface. A second antenna may also be mounted on the first communications satellite. The second antenna may include a selected beam shape for communications between the first communications satellite and the Earth. A communications system may be included for relaying communications between the first and second antennas.
    Type: Grant
    Filed: January 2, 2008
    Date of Patent: January 28, 2014
    Assignee: The Boeing Company
    Inventors: Glenn N. Caplin, James D. Thompson
  • Publication number: 20110167068
    Abstract: A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 7, 2011
    Applicant: Sizatola, LLC
    Inventors: Steven O. Kimbrough, Ian C. MacMillan, John P. Ranieri, James D. Thompson
  • Publication number: 20110097995
    Abstract: A system for communications between a lunar or planetary surface and the Earth may include a first communications satellite adapted to be positioned in a predetermined orbit relative to a celestial body. A first antenna may be mounted on the first communications satellite. The first antenna may include a predetermined beam shape for communications between the first communications satellite and an asset on the lunar or planetary surface. A second antenna may also be mounted on the first communications satellite. The second antenna may include a selected beam shape for communications between the first communications satellite and the Earth. A communications system may be included for relaying communications between the first and second antennas.
    Type: Application
    Filed: January 2, 2008
    Publication date: April 28, 2011
    Inventors: Glenn N. Caplin, James D. Thompson
  • Patent number: 7917519
    Abstract: A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: March 29, 2011
    Assignee: Sizatola, LLC
    Inventors: Steven O. Kimbrough, Ian C. MacMillan, John P. Ranieri, James D. Thompson
  • Patent number: 7558541
    Abstract: Methods and apparatus are provided for stabilizing the phase and gain of an amplifier in a power pooling arrangement. A pilot signal combining a reference carrier frequency with a reference sideband frequency is passed through the amplifier via an adjustable phase shifter and an adjustable attenuator in the amplifier input line. A portion of the amplified pilot signal is coupled from the output of the amplifier and mixed with the reference frequency. The remaining audio frequency signal is compared to a reference (input) audio signal to determine phase and gain changes during amplification in the amplifier. Phase and gain control signals are developed from this comparison, and are fed back to the adjustable phase shifter and adjustable attenuator, respectively, in order to compensate an incoming signal for phase and gain variations in the amplifier.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: July 7, 2009
    Assignee: The Boeing Company
    Inventors: Harold A. Rosen, James D. Thompson
  • Patent number: 6852535
    Abstract: A transcribed non-naturally occurring RNA molecule comprising a desired RNA molecule, wherein the 3? region of the RNA is able to base-pair with at least 8 bases at the 5? terminus of the same RNA molecule.
    Type: Grant
    Filed: August 2, 2000
    Date of Patent: February 8, 2005
    Assignee: Sirna Therapeutics, Inc.
    Inventor: James D. Thompson
  • Patent number: 6799014
    Abstract: A system and method for adjusting satellite communication signal transmit power for signals transmitted to a localized region within a satellite coverage area utilize real-time information on weather conditions (172) and/or actual path losses (174) within the localized regions to adjust the effective isotropic radiated power (EIRP) of the satellite beams (188) to minimize the total radio frequency (RF) power required for transmission. The transmission system may be realized using a variety of antenna types for transmitting spot beams and/or area coverage beams. Representative antenna implementations include multi-beam antennas having a low-level beamforming network and hybrid matrix amplifier system, phased-array with independent input amplitude control and beamsteering for each beam, and a phased-array feeding a confocal imaging system for single broadcast beam per polarization.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: September 28, 2004
    Assignee: The Boeing Company
    Inventors: Harold A. Rosen, Todd K. Citron, Steven O. Lane, James D. Thompson, Arnold L. Berman, Robert E. Vaughan
  • Publication number: 20040033568
    Abstract: The present invention relates to an enzymatic RNA molecule which cleaves mRNA derived from c-myc gene.
    Type: Application
    Filed: December 18, 2002
    Publication date: February 19, 2004
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: James D. Thompson, Kenneth G. Draper
  • Publication number: 20030186923
    Abstract: An enzymatic RNA molecule which specifically cleaves mRNA encoded by an mdr-1 gene.
    Type: Application
    Filed: May 15, 2003
    Publication date: October 2, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventor: James D. Thompson
  • Publication number: 20030162264
    Abstract: The present invention relates to an enzymatic RNA molecule which cleaves mRNA derived from c-myc gene.
    Type: Application
    Filed: December 23, 2002
    Publication date: August 28, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: James D. Thompson, Kenneth G. Draper
  • Patent number: 6544755
    Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of Burkitt's lymphoma or acute lymphocytic leukemia.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: April 8, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: James D. Thompson, Kenneth G. Draper
  • Publication number: 20030013105
    Abstract: The present invention provides methods for identifying drugs that are most specific for their intended molecular targets utilizing compounds specific for the molecular targets as model drugs in cultured cells. In various embodiments, methods are described for use of the present invention to identify non-target effects of drugs. The present invention also provides methods to identify other molecular targets for disease intervention besides the intended molecular targets of the drugs. Compounds specific for their molecular targets are preferably antisense agents.
    Type: Application
    Filed: May 1, 2002
    Publication date: January 16, 2003
    Inventors: James D. Thompson, Thale C. Jarvis
  • Publication number: 20020192685
    Abstract: Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.
    Type: Application
    Filed: March 21, 2002
    Publication date: December 19, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventor: James D. Thompson
  • Patent number: D589630
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: March 31, 2009
    Inventors: Blake D. Henson, Tim Lewis Scott, James D. Thompson