Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of lung cancer.

Abstract: A system and method for adjusting satellite communication signal transmit power for signals transmitted to a localized region within a satellite coverage area utilize real-time information on weather conditions (172) and/or actual path losses (174) within the localized regions to adjust the effective isotropic radiated power (EIRP) of the satellite beams (188) to minimize the total radio frequency (RF) power required for transmission. The transmission system may be realized using a variety of antenna types for transmitting spot beams and/or area coverage beams. Representative antenna implementations include multi-beam antennas having a low-level beamforming network and hybrid matrix amplifier system, phased-array with independent input amplitude control and beamsteering for each beam, and a phased-array feeding a confocal imaging system for single broadcast beam per polarization.

Abstract: Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.

Abstract: A reconfigurable payload for a satellite having a flexible antenna system, a variable downconverter technology and a filter technology that all work in combination to allow the payload of a satellite to be reconfigured in orbit.

Abstract: A system and method for adjusting satellite communication signal transmit power for signals transmitted to a localized region within a satellite coverage area utilize real-time information on weather conditions (172) and/or actual path losses (174) within the localized regions to adjust the effective isotropic radiated power (EIRP) of the satellite beams (188) to minimize the total radio frequency (RF) power required for transmission. The transmission system may be realized using a variety of antenna types for transmitting spot beams and/or area coverage beams. Representative antenna implementations include multi-beam antennas having a low-level beamforming network and hybrid matrix amplifier system, phased-array with independent input amplitude control and beamsteering for each beam, and a phased-array feeding a confocal imaging system for single broadcast beam per polarization.

Abstract: A reconfigurable payload for a satellite having a flexible antenna system, a variable downconverter technology and a filter technology that all work in combination to allow the payload of a satellite to be reconfigured in orbit.

Abstract: Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.

Abstract: An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.

Abstract: A transcribed non-naturally occuring RNA molecule comprising a desired RNA molecule, wherein the 3' region of the RNA is able to base-pair with at least 8 bases at the 5' terminus of the same RNA molecule.

Abstract: A beam-forming network having a network of phase shifting devices that is independent from other parts of the beam-forming network. In one embodiment, the network of phase shifting devices has multiple layers between the power divider and power combiner layers. The multiple layers provide a selectable phase shift for each feed independent from the other feeds. In another embodiment, the network of phase shifting devices is one layer of commendable phase shifters. In any embodiment, the resulting composite beam has higher directivity and lower side lobes as compared to conventional beam-forming networks.

Abstract: An enzymatic RNA molecule which specifically cleaves mRNA encoded by an mdr-1 gene.

Abstract: An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.

Abstract: Amplifier-induced intermodulation distortion (IMD) is reduced by encoding a multi-frequency input composite signal into multiple encoded signals that vary from each other in their power amplitudes as a function of frequency, amplifying the encoded signals, and then decoding them in a complementary fashion so as to differentiate between the amplified signal components and the IMD components. The amplified signal components are coherently combined to separate them from the IMD components, which are incoherently combined. The input signal is preferably encoded by dividng it into multiple divided signals, introducing relative phase shifts between the divided signals that vary as a function of frequency, and combining the divided and phase shifted signals with each other in a Butler matrix prior to amplification. The phase shifts are introduced by means of time delays that are preferably equal to integer multiples of 4.PI. divided by the input signal bandwidth.

Abstract: A coaxial "M" switch having three coaxial input connectors (A, B, C) spaced evenly from each other, and three coaxial output connectors (1, 2, 3) identically arranged. In a cylindrical barrel embodiment (10) the input and output connectors are located at opposite ends of a cylindrical configuration. In one planar embodiment (30), the input and output connectors alternate with each other and define a hexagonal configuration (40). In another planar embodiment, the input connectors (A, B, C) define an inner triangular configuration (70) that is surrounded by the output connectors (1, 2, 3) defining an outer triangular configuration. In each embodiment, reeds are actuated in predetermined configurations to define three switch positions.

Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of colon carcinoma.

Abstract: A mobile, satellite-based communication system includes a defined signaling arrangement developed from an analysis of factors including movement of the mobile terminals, movement of the satellite, beam discrepancies and duration of the call to the mobile terminal to set up a frame assignment plan for time division multiple access (TDMA) carriers and identifying permissible frame offset which can be accommodated throughout the entire transmission. As a result, timing and frequency references from a mobile to mobile command (MMC) may be provided from a reference source along with receive and transmit data communications without losing the command signals or the communication information and providing highly efficient use of each carriers time slots for receiving transmitting communication signals. Similarly, the signaling arrangement permits an efficient frame structure and a time slot assignment plan that does not require enhanced equipment at the mobile terminal.

Abstract: An enzymatic RNA molecule which cleaves bcl.2 mRNA associated with development or maintenance of follicular lymphoma.

Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of CML.

Abstract: An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.

Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of promyelocytic leukemia.